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- W4377087306 abstract "Abstract Purpose Chimeric antigen receptor T-cell (CART) therapy has shown clinical efficacy in refractory and relapsed large B-cell lymphomas, but is associated with serious acute and long-term toxicities. To understand the patient perspective, we measured a patient-reported outcome (PRO), specifically, health-related quality of life (HRQoL), at multiple time points over one year. Methods This was a prospective feasibility study of a cohort of patients who were eligible for standard of care CART therapy, tisagenlecleucel. Demographic data and disease characteristics were collected. HRQoL was measured using FACT-Lym at baseline, and months 1, 3, 6 and 12. FACT-Lym includes FACT-G (physical, social, emotional and functional well-being domains), plus a lymphoma subscale. Results Thirty-four of 35 patients approached, consented to participate. Two of them did not receive their infusion due to progressive disease. Fifty percent were female and median age was 62 (23–77). Twenty-nine patients (91%) completed baseline FACT-Lym and 20 of 21 (95%) eligible patients completed 12-month FACT-Lym. 52% completed all 4 post-baseline FACT-Lym measures. Exploratory analyses for changes in FACT-Lym scores are reported. Conclusion It is feasible to measure longitudinal PROs in patients who receive CART therapy. This study will inform future studies in evaluating innovative ways to administer CART therapy." @default.
- W4377087306 created "2023-05-20" @default.
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- W4377087306 date "2023-05-19" @default.
- W4377087306 modified "2023-10-16" @default.
- W4377087306 title "Feasibility of collecting longitudinal patient-reported outcomes in individuals with relapsed or refractory large B-cell lymphoma who received chimeric antigen receptor T-cell (CART) therapy" @default.
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- W4377087306 doi "https://doi.org/10.21203/rs.3.rs-2907146/v1" @default.
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