Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377087413> ?p ?o ?g. }
- W4377087413 abstract "Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge study, exposing atopic dermatitis patients to house dust mite. Here we analyse transcriptional programmes at the population and single cell levels in parallel with immunophenotyping of cutaneous immunocytes revealed a distinct dichotomy in atopic dermatitis patient responsiveness to house dust mite challenge. Our study shows that reactivity to house dust mite was associated with high basal levels of TNF-expressing cutaneous Th17 T cells, and documents the presence of hub structures where Langerhans cells and T cells co-localised. Mechanistically, we identify expression of metallothioneins and transcriptional programmes encoding antioxidant defences across all skin cell types, that appear to protect against allergen-induced inflammation. Furthermore, single nucleotide polymorphisms in the MTIX gene are associated with patients who did not react to house dust mite, opening up possibilities for therapeutic interventions modulating metallothionein expression in atopic dermatitis." @default.
- W4377087413 created "2023-05-20" @default.
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- W4377087413 date "2023-05-19" @default.
- W4377087413 modified "2023-09-26" @default.
- W4377087413 title "Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis" @default.
- W4377087413 cites W1606922774 @default.
- W4377087413 cites W1966327575 @default.
- W4377087413 cites W1974692569 @default.
- W4377087413 cites W1979758192 @default.
- W4377087413 cites W1984525156 @default.
- W4377087413 cites W2003774999 @default.
- W4377087413 cites W2008810664 @default.
- W4377087413 cites W2018043147 @default.
- W4377087413 cites W2029673387 @default.
- W4377087413 cites W2035165308 @default.
- W4377087413 cites W2036632318 @default.
- W4377087413 cites W2037681298 @default.
- W4377087413 cites W2046580930 @default.
- W4377087413 cites W2050654160 @default.
- W4377087413 cites W2053064795 @default.
- W4377087413 cites W2053134332 @default.
- W4377087413 cites W2063478454 @default.
- W4377087413 cites W2066224059 @default.
- W4377087413 cites W2068259827 @default.
- W4377087413 cites W2068419991 @default.
- W4377087413 cites W2074546623 @default.
- W4377087413 cites W2075541573 @default.
- W4377087413 cites W2086692340 @default.
- W4377087413 cites W2088186226 @default.
- W4377087413 cites W2088412871 @default.
- W4377087413 cites W2090775309 @default.
- W4377087413 cites W2095325567 @default.
- W4377087413 cites W2097091578 @default.
- W4377087413 cites W2102212449 @default.
- W4377087413 cites W2102619694 @default.
- W4377087413 cites W2108234281 @default.
- W4377087413 cites W2114104545 @default.
- W4377087413 cites W2119180969 @default.
- W4377087413 cites W2120334440 @default.
- W4377087413 cites W2124220100 @default.
- W4377087413 cites W2124580054 @default.
- W4377087413 cites W2124649657 @default.
- W4377087413 cites W2134582937 @default.
- W4377087413 cites W2143710073 @default.
- W4377087413 cites W2146302565 @default.
- W4377087413 cites W2190545194 @default.
- W4377087413 cites W2278683490 @default.
- W4377087413 cites W2323326409 @default.
- W4377087413 cites W2335687927 @default.
- W4377087413 cites W2343858810 @default.
- W4377087413 cites W2345356016 @default.
- W4377087413 cites W2396875337 @default.
- W4377087413 cites W2411361269 @default.
- W4377087413 cites W2417483443 @default.
- W4377087413 cites W2541283511 @default.
- W4377087413 cites W2549858476 @default.
- W4377087413 cites W2604389567 @default.
- W4377087413 cites W2613543041 @default.
- W4377087413 cites W2619553685 @default.
- W4377087413 cites W2620721366 @default.
- W4377087413 cites W2772692099 @default.
- W4377087413 cites W2790169088 @default.
- W4377087413 cites W2800392236 @default.
- W4377087413 cites W2802753517 @default.
- W4377087413 cites W2913468892 @default.
- W4377087413 cites W2924384775 @default.
- W4377087413 cites W2950549285 @default.
- W4377087413 cites W2978980575 @default.
- W4377087413 cites W2999630643 @default.
- W4377087413 cites W3007935255 @default.
- W4377087413 cites W3037482866 @default.
- W4377087413 cites W3046538729 @default.
- W4377087413 cites W3106188259 @default.
- W4377087413 cites W3107527779 @default.
- W4377087413 cites W3122917998 @default.
- W4377087413 cites W3124296497 @default.
- W4377087413 cites W3128091223 @default.
- W4377087413 cites W3163061470 @default.