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- W4377091330 abstract "Abstract Biological assay and imaging techniques have made visible a great deal of the machinery of mental illness. Over fifty years of investigation of mood disorders using these technologies has identified several biological regularities in these disorders. Here we present a narrative connecting genetic, cytokine, neurotransmitter, and neural-systems-level findings in major depressive disorder (MDD). Specifically, we connect recent genome-wide findings in MDD to metabolic and immunological disturbance in this disorder and then detail links between immunological abnormalities and dopaminergic signaling within cortico-striatal circuitry. Following this, we discuss implications of reduced dopaminergic tone for cortico-striatal signal conduction in MDD. Finally, we specify some of the flaws in the current model and propose ways forward for advancing multilevel formulations of MDD most efficiently." @default.
- W4377091330 created "2023-05-20" @default.
- W4377091330 creator A5013861574 @default.
- W4377091330 creator A5026199142 @default.
- W4377091330 creator A5047653603 @default.
- W4377091330 creator A5083117203 @default.
- W4377091330 creator A5087240695 @default.
- W4377091330 date "2023-05-19" @default.
- W4377091330 modified "2023-10-14" @default.
- W4377091330 title "Towards a multilevel model of major depression: genes, immuno-metabolic function, and cortico-striatal signaling" @default.
- W4377091330 cites W1159730949 @default.
- W4377091330 cites W1535378236 @default.
- W4377091330 cites W1542275754 @default.
- W4377091330 cites W1547937746 @default.
- W4377091330 cites W1598480899 @default.
- W4377091330 cites W1627352250 @default.
- W4377091330 cites W170336404 @default.
- W4377091330 cites W1793035576 @default.
- W4377091330 cites W1972583081 @default.
- W4377091330 cites W1973483415 @default.
- W4377091330 cites W1976435745 @default.
- W4377091330 cites W1983949227 @default.
- W4377091330 cites W1985438873 @default.
- W4377091330 cites W1993258961 @default.
- W4377091330 cites W2002834809 @default.
- W4377091330 cites W2003982930 @default.
- W4377091330 cites W2009033372 @default.
- W4377091330 cites W2009064331 @default.
- W4377091330 cites W2014727433 @default.
- W4377091330 cites W2015016479 @default.
- W4377091330 cites W2016414626 @default.
- W4377091330 cites W2017709022 @default.
- W4377091330 cites W2018375045 @default.
- W4377091330 cites W2022390426 @default.
- W4377091330 cites W2022766686 @default.
- W4377091330 cites W2029942338 @default.
- W4377091330 cites W2031170958 @default.
- W4377091330 cites W2037226098 @default.
- W4377091330 cites W2037586492 @default.
- W4377091330 cites W2043314401 @default.
- W4377091330 cites W2050827499 @default.
- W4377091330 cites W2053418274 @default.
- W4377091330 cites W2060050678 @default.
- W4377091330 cites W2061951979 @default.
- W4377091330 cites W2065692954 @default.
- W4377091330 cites W2067456724 @default.
- W4377091330 cites W2068915304 @default.
- W4377091330 cites W2073144071 @default.
- W4377091330 cites W2090763917 @default.
- W4377091330 cites W2091890724 @default.
- W4377091330 cites W2099652807 @default.
- W4377091330 cites W2099921986 @default.
- W4377091330 cites W2117593813 @default.
- W4377091330 cites W2120625327 @default.
- W4377091330 cites W2123541107 @default.
- W4377091330 cites W2126795224 @default.
- W4377091330 cites W2136148200 @default.
- W4377091330 cites W2140660757 @default.
- W4377091330 cites W2144903977 @default.
- W4377091330 cites W2146659162 @default.
- W4377091330 cites W2146758523 @default.
- W4377091330 cites W2148132316 @default.
- W4377091330 cites W2149862171 @default.
- W4377091330 cites W2149863291 @default.
- W4377091330 cites W2150077660 @default.
- W4377091330 cites W2156150528 @default.
- W4377091330 cites W2159082363 @default.
- W4377091330 cites W2161059139 @default.
- W4377091330 cites W2162091209 @default.
- W4377091330 cites W2170029299 @default.
- W4377091330 cites W2201607793 @default.
- W4377091330 cites W2206490240 @default.
- W4377091330 cites W2306879415 @default.
- W4377091330 cites W2411582483 @default.
- W4377091330 cites W2415522813 @default.
- W4377091330 cites W2438144546 @default.
- W4377091330 cites W2440441367 @default.
- W4377091330 cites W2492077070 @default.
- W4377091330 cites W2532143627 @default.
- W4377091330 cites W2560565629 @default.
- W4377091330 cites W2582903515 @default.
- W4377091330 cites W2594929787 @default.
- W4377091330 cites W2626367934 @default.
- W4377091330 cites W2738082385 @default.
- W4377091330 cites W2752391795 @default.
- W4377091330 cites W2790755079 @default.
- W4377091330 cites W2798099314 @default.
- W4377091330 cites W2803703235 @default.
- W4377091330 cites W2887675009 @default.
- W4377091330 cites W2891257524 @default.
- W4377091330 cites W2902437032 @default.
- W4377091330 cites W2911487850 @default.
- W4377091330 cites W2953025937 @default.
- W4377091330 cites W2977695626 @default.
- W4377091330 cites W2979832543 @default.
- W4377091330 cites W3003575299 @default.
- W4377091330 cites W3122507014 @default.
- W4377091330 cites W3124601103 @default.
- W4377091330 cites W3157348623 @default.
- W4377091330 cites W3213166294 @default.