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- W4377092819 abstract "Abstract Objective The goal of this study was to investigate laparoscopic sleeve gastrectomy (LSG)‐induced changes in choice impulsivity and the neural correlates in individuals with obesity (OB). Methods The study employed functional magnetic resonance imaging with a delay discounting task in 29 OB tested before and 1 month after LSG. Thirty participants with normal weight matched to OB with gender and age were recruited as the control group and underwent an identical functional magnetic resonance imaging scan. Alterations in activation and functional connectivity between pre‐ and post‐LSG were investigated and compared with participants with normal weight. Results OB exhibited significantly reduced discounting rate after LSG. During the delay discounting task, hyperactivation in dorsolateral prefrontal cortex, right caudate, and dorsomedial prefrontal cortex decreased in OB after LSG. LSG additionally engaged compensatory effects through increased activation in bilateral posterior insula and functional connectivity between caudate and dorsomedial prefrontal cortex. Those changes were associated with decreased discounting rate and BMI as well as improved eating behaviors. Conclusions These findings indicate that decreased choice impulsivity following LSG was associated with the changes in regions involved in executive control, reward evaluation, interoception, and prospection. This study may provide neurophysiological support for the development of nonoperative treatments such as brain stimulation for individuals with obesity and overweight." @default.
- W4377092819 created "2023-05-20" @default.
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- W4377092819 date "2023-05-19" @default.
- W4377092819 modified "2023-10-18" @default.
- W4377092819 title "Neural correlates of decreased impulsivity during delay discounting task after laparoscopic sleeve gastrectomy" @default.
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- W4377092819 doi "https://doi.org/10.1002/oby.23763" @default.
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