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- W4377092853 endingPage "e1011318" @default.
- W4377092853 startingPage "e1011318" @default.
- W4377092853 abstract "Mycobacterium abscessus is a nontuberculosis mycobacterium (NTM) that has shown an exponential rise in its ability to cause disease. Due to its ubiquitous presence in the environment, M . abscessus is widely implicated in secondary exacerbations of many nosocomial infections and genetic respiratory disorders, such as cystic fibrosis (CF). Contrary to other rapidly growing NTMs, the cell envelope of M . abscessus harbors several prominent features and undergoes modifications that are responsible for its pathogenesis. Compositional changes of the mycobacterial outer membrane (MOM) significantly decrease the presence of glycopeptidolipids (GPLs) and enable the transition from a colonizing, smooth morphotype into a virulent, rough morphotype. The GPLs are transported to the MOM by the Mycobacterial membrane proteins Large (MmpL), which further act as drug efflux pumps and confer antibiotic resistance. Lastly, M . abscessus possesses 2 type VII secretion systems (T7SS): ESX-3 and ESX-4, both of which have recently been implicated in host–pathogen interactions and virulence. This review summarizes the current knowledge of M . abscessus pathogenesis and highlights the clinically relevant association between the structure and functions of its cell envelope." @default.
- W4377092853 created "2023-05-20" @default.
- W4377092853 creator A5045546898 @default.
- W4377092853 creator A5069632365 @default.
- W4377092853 date "2023-05-18" @default.
- W4377092853 modified "2023-09-27" @default.
- W4377092853 title "The cell envelope of Mycobacterium abscessus and its role in pathogenesis" @default.
- W4377092853 cites W1179013240 @default.
- W4377092853 cites W1508212288 @default.
- W4377092853 cites W1821989371 @default.
- W4377092853 cites W1866989478 @default.
- W4377092853 cites W1985870591 @default.
- W4377092853 cites W1998978084 @default.
- W4377092853 cites W2009475906 @default.
- W4377092853 cites W2023339317 @default.
- W4377092853 cites W2026042024 @default.
- W4377092853 cites W2038672409 @default.
- W4377092853 cites W2057740405 @default.
- W4377092853 cites W2071637240 @default.
- W4377092853 cites W2074401088 @default.
- W4377092853 cites W2078178166 @default.
- W4377092853 cites W2078567653 @default.
- W4377092853 cites W2090417529 @default.
- W4377092853 cites W2095357096 @default.
- W4377092853 cites W2096830865 @default.
- W4377092853 cites W2098107406 @default.
- W4377092853 cites W2101358576 @default.
- W4377092853 cites W2108459792 @default.
- W4377092853 cites W2116780041 @default.
- W4377092853 cites W2118648921 @default.
- W4377092853 cites W2119462342 @default.
- W4377092853 cites W2130599662 @default.
- W4377092853 cites W2136327514 @default.
- W4377092853 cites W2138103170 @default.
- W4377092853 cites W2141115207 @default.
- W4377092853 cites W2142447693 @default.
- W4377092853 cites W2152378366 @default.
- W4377092853 cites W2155181416 @default.
- W4377092853 cites W2167703036 @default.
- W4377092853 cites W2168348711 @default.
- W4377092853 cites W2171774303 @default.
- W4377092853 cites W2177577861 @default.
- W4377092853 cites W2177935900 @default.
- W4377092853 cites W2225338927 @default.
- W4377092853 cites W2232400010 @default.
- W4377092853 cites W2252796558 @default.
- W4377092853 cites W2300801912 @default.
- W4377092853 cites W2301131921 @default.
- W4377092853 cites W2333741177 @default.
- W4377092853 cites W2340254326 @default.
- W4377092853 cites W2405978957 @default.
- W4377092853 cites W2413218470 @default.
- W4377092853 cites W2415837551 @default.
- W4377092853 cites W2469803725 @default.
- W4377092853 cites W2518975397 @default.
- W4377092853 cites W2527411440 @default.
- W4377092853 cites W2528800583 @default.
- W4377092853 cites W2529180302 @default.
- W4377092853 cites W2556885571 @default.
- W4377092853 cites W2558222949 @default.
- W4377092853 cites W2580358075 @default.
- W4377092853 cites W2598263426 @default.
- W4377092853 cites W2607561273 @default.
- W4377092853 cites W2738189269 @default.
- W4377092853 cites W2781862115 @default.
- W4377092853 cites W2783698286 @default.
- W4377092853 cites W2794635427 @default.
- W4377092853 cites W2803716777 @default.
- W4377092853 cites W2805728298 @default.
- W4377092853 cites W2809941350 @default.
- W4377092853 cites W2889161855 @default.
- W4377092853 cites W2889876568 @default.
- W4377092853 cites W2895841615 @default.
- W4377092853 cites W2897003522 @default.
- W4377092853 cites W2899469009 @default.
- W4377092853 cites W2901406400 @default.
- W4377092853 cites W2902814816 @default.
- W4377092853 cites W2913689157 @default.
- W4377092853 cites W2914162790 @default.
- W4377092853 cites W2919719496 @default.
- W4377092853 cites W2952404779 @default.
- W4377092853 cites W2963985285 @default.
- W4377092853 cites W2979491247 @default.
- W4377092853 cites W2991337044 @default.
- W4377092853 cites W2997527981 @default.
- W4377092853 cites W3009004529 @default.
- W4377092853 cites W3016917733 @default.
- W4377092853 cites W3034282085 @default.
- W4377092853 cites W3044540098 @default.
- W4377092853 cites W3046494094 @default.
- W4377092853 cites W3111588420 @default.
- W4377092853 cites W3130086203 @default.
- W4377092853 cites W3133984158 @default.
- W4377092853 cites W3134018779 @default.
- W4377092853 cites W3163944831 @default.
- W4377092853 cites W3165713878 @default.
- W4377092853 cites W3173623241 @default.
- W4377092853 cites W3178989966 @default.