Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377092989> ?p ?o ?g. }
- W4377092989 abstract "Abstract Giardia lamblia (Giardia) is among the most common intestinal pathogens in children in low- and middle-income countries (LMICs). Although Giardia associates with early-life linear growth restriction, mechanistic explanations for Giardia- associated growth impairments remain elusive. Unlike other intestinal pathogens associated with constrained linear growth that cause intestinal or systemic inflammation or both, Giardia seldom associates with chronic inflammation in these children. Here we leverage the MAL-ED longitudinal birth cohort and a model of Giardia mono-association in gnotobiotic and immunodeficient mice to propose an alternative pathogenesis of this parasite. In children, Giardia results in linear growth deficits and gut permeability that are dose-dependent and independent of intestinal markers of inflammation. The estimates of these findings vary between children in different MAL-ED sites. In a representative site, where Giardia associates with growth restriction, infected children demonstrate broad amino acid deficiencies, and overproduction of specific phenolic acids, byproducts of intestinal bacterial amino acid metabolism. Gnotobiotic mice require specific nutritional and environmental conditions to recapitulate these findings, and immunodeficient mice confirm a pathway independent of chronic T/B cell inflammation. Taken together, we propose a new paradigm that Giardia -mediated growth faltering is contingent upon a convergence of this intestinal protozoa with nutritional and intestinal bacterial factors." @default.
- W4377092989 created "2023-05-20" @default.
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- W4377092989 date "2023-05-18" @default.
- W4377092989 modified "2023-10-16" @default.
- W4377092989 title "Giardia hinders growth by disrupting nutrient metabolism independent of inflammatory enteropathy" @default.
- W4377092989 cites W1581336773 @default.
- W4377092989 cites W1651027427 @default.
- W4377092989 cites W1795895958 @default.
- W4377092989 cites W1968712913 @default.
- W4377092989 cites W1975607315 @default.
- W4377092989 cites W1989645075 @default.
- W4377092989 cites W2003006324 @default.
- W4377092989 cites W2008195801 @default.
- W4377092989 cites W2013765955 @default.
- W4377092989 cites W2023628159 @default.
- W4377092989 cites W2045241989 @default.
- W4377092989 cites W2051366884 @default.
- W4377092989 cites W2054928810 @default.
- W4377092989 cites W2055074417 @default.
- W4377092989 cites W2069637401 @default.
- W4377092989 cites W2073768215 @default.
- W4377092989 cites W2078497184 @default.
- W4377092989 cites W2083637865 @default.
- W4377092989 cites W2091689748 @default.
- W4377092989 cites W2097478615 @default.
- W4377092989 cites W2100059937 @default.
- W4377092989 cites W2101451490 @default.
- W4377092989 cites W2111447050 @default.
- W4377092989 cites W2112845897 @default.
- W4377092989 cites W2117381088 @default.
- W4377092989 cites W2117992130 @default.
- W4377092989 cites W2126559542 @default.
- W4377092989 cites W2127950835 @default.
- W4377092989 cites W2134727867 @default.
- W4377092989 cites W2141351365 @default.
- W4377092989 cites W2142873078 @default.
- W4377092989 cites W2149489583 @default.
- W4377092989 cites W2150169200 @default.
- W4377092989 cites W2164482333 @default.
- W4377092989 cites W2266975378 @default.
- W4377092989 cites W2272600231 @default.
- W4377092989 cites W2280457477 @default.
- W4377092989 cites W2331191252 @default.
- W4377092989 cites W2411626217 @default.
- W4377092989 cites W2418854787 @default.
- W4377092989 cites W2422079507 @default.
- W4377092989 cites W2460389469 @default.
- W4377092989 cites W2500688207 @default.
- W4377092989 cites W2516414038 @default.
- W4377092989 cites W2521607002 @default.
- W4377092989 cites W2578450331 @default.
- W4377092989 cites W2588331788 @default.
- W4377092989 cites W2590003621 @default.
- W4377092989 cites W2592653282 @default.
- W4377092989 cites W2606004738 @default.
- W4377092989 cites W2610481686 @default.
- W4377092989 cites W2740645471 @default.
- W4377092989 cites W2776301743 @default.
- W4377092989 cites W2808256838 @default.
- W4377092989 cites W2809105508 @default.
- W4377092989 cites W2892227792 @default.
- W4377092989 cites W2892815535 @default.
- W4377092989 cites W2893167551 @default.
- W4377092989 cites W2920091576 @default.
- W4377092989 cites W2950835870 @default.
- W4377092989 cites W2953474949 @default.
- W4377092989 cites W2974598582 @default.
- W4377092989 cites W2989484246 @default.
- W4377092989 cites W2995754215 @default.
- W4377092989 cites W3045325141 @default.
- W4377092989 cites W3092581495 @default.
- W4377092989 cites W3092771220 @default.
- W4377092989 cites W3119504543 @default.
- W4377092989 cites W3128271116 @default.
- W4377092989 cites W3199699228 @default.
- W4377092989 cites W4248809622 @default.
- W4377092989 cites W4297598437 @default.