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- W4377094466 abstract "Background. Primary graft dysfunction, which is directly related to cold ischemia–reperfusion (CI/R) injury, is a major obstacle in lung transplantation (LTx). Ferroptosis, a novel mode of cell death elicited by iron-dependent lipid peroxidation, has been implicated in ischemic events. This study aimed to investigate the role of ferroptosis in LTx-CI/R injury and the effectiveness of liproxstatin-1 (Lip-1), a ferroptosis inhibitor, in alleviating LTx-CI/R injury. Methods. LTx-CI/R-induced signal pathway alterations, tissue injury, cell death, inflammatory responses, and ferroptotic features were examined in human lung biopsies, the human bronchial epithelial (BEAS-2B) cells, and the mouse LTx-CI/R model (24-h CI/4-h R). The therapeutic efficacy of Lip-1 was explored and validated both in vitro and in vivo. Results. In human lung tissues, LTx-CI/R activated ferroptosis-related signaling pathway, increased the tissue iron content and lipid peroxidation accumulation, and altered key protein (GPX4, COX2, Nrf2, and SLC7A11) expression and mitochondrial morphology. In BEAS-2B cells, the hallmarks of ferroptosis were significantly evidenced at the setting of both CI and CI/R compared with the control, and the effect of adding Lip-1 only during CI was much better than that of only during reperfusion by Cell Counting Kit-8. Furthermore, Lip-1 administration during CI markedly relieved LTx-CI/R injury in mice, as indicated by significant improvement in lung pathological changes, pulmonary function, inflammation, and ferroptosis. Conclusions. This study revealed the existence of ferroptosis in the pathophysiology of LTx-CI/R injury. Using Lip-1 to inhibit ferroptosis during CI could ameliorate LTx-CI/R injury, suggesting that Lip-1 administration might be proposed as a new strategy for organ preservation." @default.
- W4377094466 created "2023-05-20" @default.
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- W4377094466 date "2023-05-19" @default.
- W4377094466 modified "2023-10-16" @default.
- W4377094466 title "Liproxstatin-1 Alleviates Lung Transplantation-induced Cold Ischemia–Reperfusion Injury by Inhibiting Ferroptosis" @default.
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- W4377094466 cites W1969501903 @default.
- W4377094466 cites W1971811578 @default.
- W4377094466 cites W1976648730 @default.
- W4377094466 cites W1977327120 @default.
- W4377094466 cites W1982388830 @default.
- W4377094466 cites W1983688860 @default.
- W4377094466 cites W1989694397 @default.
- W4377094466 cites W1992525410 @default.
- W4377094466 cites W1997183854 @default.
- W4377094466 cites W2000662692 @default.
- W4377094466 cites W2002490399 @default.
- W4377094466 cites W2004020718 @default.
- W4377094466 cites W2028015705 @default.
- W4377094466 cites W2035898183 @default.
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- W4377094466 cites W2738002757 @default.
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- W4377094466 cites W2916144846 @default.
- W4377094466 cites W2923490324 @default.
- W4377094466 cites W2928665623 @default.
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- W4377094466 cites W2947494849 @default.
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- W4377094466 cites W2999078431 @default.
- W4377094466 cites W3000699351 @default.
- W4377094466 cites W3005611976 @default.
- W4377094466 cites W3012507702 @default.
- W4377094466 cites W3019749735 @default.
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- W4377094466 cites W3039789423 @default.
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- W4377094466 cites W3108786331 @default.
- W4377094466 cites W3123922203 @default.
- W4377094466 cites W3126324707 @default.
- W4377094466 cites W3142512822 @default.
- W4377094466 cites W3175617818 @default.
- W4377094466 cites W4220984395 @default.
- W4377094466 cites W4223567523 @default.
- W4377094466 cites W4224211693 @default.
- W4377094466 cites W4224536768 @default.
- W4377094466 cites W4240932329 @default.
- W4377094466 cites W4281388265 @default.
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- W4377094466 doi "https://doi.org/10.1097/tp.0000000000004638" @default.
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- W4377094466 hasPublicationYear "2023" @default.
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