Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377094826> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4377094826 abstract "Accumulation of adipose tissue within and outside of skeletal muscle is associated with orthopedic injury and metabolic disease, where it is thought to impede muscle function. The close juxtaposition between this adipose and myofibers has led to hypotheses that paracrine interactions between the two regulate local physiology. Recent work suggests that intramuscular adipose tissue (IMAT) may have features of beige or brown fat, indicated by the expression of uncoupling protein-1 (UCP-1). However, this is contested by other studies. Clarification of this point is needed to inform our understanding of the relationship between IMAT and muscle health. To achieve this, we examined the effects of constitutive UCP-1+ cell ablation (UCP1-DTA) on IMAT development and homeostasis. IMAT developed normally in UCP1-DTA mice, with no significant differences in quantity compared with wild-type littermates. Likewise, IMAT accumulation in response to glycerol-induced injury was similar between genotypes, with no significant differences in adipocyte size, quantity, or dispersion. This suggests that neither physiological nor pathological IMAT express UCP-1 and that the development of IMAT does not depend on UCP-1 lineage cells. In response to β3-adrenergic stimulation, we find minor, localized UCP-1 positivity in wildtype IMAT, but the bulk of the adipocytes are unresponsive. In contrast, two depots of muscle-adjacent (epi-muscular) adipose tissue have reduced mass in UCP1-DTA mice and UCP-1 positivity in wildtype littermates, comparable to traditional beige and brown adipose depots. Taken together this evidence strongly supports a white adipose phenotype for mouse IMAT and a brown/beige phenotype for some adipose outside the muscle boundary." @default.
- W4377094826 created "2023-05-20" @default.
- W4377094826 creator A5020080618 @default.
- W4377094826 creator A5021252183 @default.
- W4377094826 creator A5062600742 @default.
- W4377094826 creator A5068159926 @default.
- W4377094826 creator A5083491517 @default.
- W4377094826 creator A5088601071 @default.
- W4377094826 date "2023-05-25" @default.
- W4377094826 modified "2023-10-14" @default.
- W4377094826 title "Development and expansion of intramuscular adipose tissue is not dependent on UCP‐1‐lineage cells in mice" @default.
- W4377094826 cites W1843349889 @default.
- W4377094826 cites W1998646863 @default.
- W4377094826 cites W2004803010 @default.
- W4377094826 cites W2021760176 @default.
- W4377094826 cites W2025838486 @default.
- W4377094826 cites W2038657829 @default.
- W4377094826 cites W2051039956 @default.
- W4377094826 cites W2051070727 @default.
- W4377094826 cites W2057597513 @default.
- W4377094826 cites W2062421379 @default.
- W4377094826 cites W2066749771 @default.
- W4377094826 cites W2110298453 @default.
- W4377094826 cites W2160811167 @default.
- W4377094826 cites W2164045012 @default.
- W4377094826 cites W2206194366 @default.
- W4377094826 cites W2239817872 @default.
- W4377094826 cites W2518904228 @default.
- W4377094826 cites W2570074708 @default.
- W4377094826 cites W2790054958 @default.
- W4377094826 cites W2902358898 @default.
- W4377094826 cites W2908105398 @default.
- W4377094826 cites W2943354426 @default.
- W4377094826 cites W2989616709 @default.
- W4377094826 cites W2990946033 @default.
- W4377094826 cites W3011739739 @default.
- W4377094826 cites W3022499895 @default.
- W4377094826 cites W3110661317 @default.
- W4377094826 cites W4281399523 @default.
- W4377094826 cites W4313560424 @default.
- W4377094826 doi "https://doi.org/10.1002/jor.25627" @default.
- W4377094826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37203780" @default.
- W4377094826 hasPublicationYear "2023" @default.
- W4377094826 type Work @default.
- W4377094826 citedByCount "0" @default.
- W4377094826 crossrefType "journal-article" @default.
- W4377094826 hasAuthorship W4377094826A5020080618 @default.
- W4377094826 hasAuthorship W4377094826A5021252183 @default.
- W4377094826 hasAuthorship W4377094826A5062600742 @default.
- W4377094826 hasAuthorship W4377094826A5068159926 @default.
- W4377094826 hasAuthorship W4377094826A5083491517 @default.
- W4377094826 hasAuthorship W4377094826A5088601071 @default.
- W4377094826 hasConcept C126322002 @default.
- W4377094826 hasConcept C134018914 @default.
- W4377094826 hasConcept C140985366 @default.
- W4377094826 hasConcept C151279926 @default.
- W4377094826 hasConcept C151955695 @default.
- W4377094826 hasConcept C171089720 @default.
- W4377094826 hasConcept C2776175234 @default.
- W4377094826 hasConcept C2780642333 @default.
- W4377094826 hasConcept C71924100 @default.
- W4377094826 hasConcept C81979416 @default.
- W4377094826 hasConcept C86803240 @default.
- W4377094826 hasConceptScore W4377094826C126322002 @default.
- W4377094826 hasConceptScore W4377094826C134018914 @default.
- W4377094826 hasConceptScore W4377094826C140985366 @default.
- W4377094826 hasConceptScore W4377094826C151279926 @default.
- W4377094826 hasConceptScore W4377094826C151955695 @default.
- W4377094826 hasConceptScore W4377094826C171089720 @default.
- W4377094826 hasConceptScore W4377094826C2776175234 @default.
- W4377094826 hasConceptScore W4377094826C2780642333 @default.
- W4377094826 hasConceptScore W4377094826C71924100 @default.
- W4377094826 hasConceptScore W4377094826C81979416 @default.
- W4377094826 hasConceptScore W4377094826C86803240 @default.
- W4377094826 hasLocation W43770948261 @default.
- W4377094826 hasLocation W43770948262 @default.
- W4377094826 hasOpenAccess W4377094826 @default.
- W4377094826 hasPrimaryLocation W43770948261 @default.
- W4377094826 hasRelatedWork W129097138 @default.
- W4377094826 hasRelatedWork W1982275498 @default.
- W4377094826 hasRelatedWork W2139237034 @default.
- W4377094826 hasRelatedWork W2510840747 @default.
- W4377094826 hasRelatedWork W2519472217 @default.
- W4377094826 hasRelatedWork W2762948888 @default.
- W4377094826 hasRelatedWork W2980740621 @default.
- W4377094826 hasRelatedWork W3029715290 @default.
- W4377094826 hasRelatedWork W3047633609 @default.
- W4377094826 hasRelatedWork W3138566262 @default.
- W4377094826 isParatext "false" @default.
- W4377094826 isRetracted "false" @default.
- W4377094826 workType "article" @default.