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- W4377096598 abstract "Oncolytic viruses (OVs) could be the next breakthrough in oncology. The primary objective of this study was to gain a more thorough understanding of OVs in advanced malignancies. This study reviewed 161 clinical studies, including 4,300 patients with advanced cancer. We summarized the antitumor immune response and clinical response to OVs. Moreover, TRAEs, adverse events attributable to OVs, were summarized by grade. 52 (52/161, 32.3%) studies assessed the tumor microenvironment, most of which reported that CD8 + T cells (N = 31) and PD-L1 (N=9) were increased. 60 (60/161, 37.3%) studies reported increased systemic immune responses, including IFN-γ (N=27), IL-6 (N=22) and CD8 + T cells (N=20). A total of 106 (106/161, 65.8%) studies evaluated clinical efficacy in 2,631 patients, with objective response and disease control rates of 621 (23.6%) and 1603 (60.9%), respectively. Subgroup analysis showed an objective response in 352 (30.8%) and disease control in 704 (62.2%) of 1143 patients in the HSV subgroup. The percentages of patients with objective response and disease control for different administration routes, including intratumoral injection (25.8%; 62.2%) and intravenous injection (20.2%; 56.8%), and for different treatment options, including combination therapy (31.3%; 69.8%) and OVs monotherapy (17.8%; 54.3%), were summarized. For different combination therapies, OVs plus immunotherapy may be promising, with objective response and disease control at elevated proportions (39.6%; 66.3%). Moreover, OVs demonstrated a manageable safety profile, with most TRAEs being grade 1-2. In summary, OVs that activate innate and specific immune responses that ultimately enhance the antitumor response deserve further investigation." @default.
- W4377096598 created "2023-05-20" @default.
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- W4377096598 date "2023-05-19" @default.
- W4377096598 modified "2023-10-16" @default.
- W4377096598 title "Efficacy and Safety of Oncolytic Virus Immunotherapy in Advanced Malignancies: A Systematic Review of 161 Clinical Studies" @default.
- W4377096598 doi "https://doi.org/10.22541/au.168449090.04261766/v1" @default.
- W4377096598 hasPublicationYear "2023" @default.
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