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• W4377097026 abstract "The study was conducted in Jilin province to investigate the mechanism involved in the antibiotic resistance and pathogenicity of Klebsiella pneumoniae (K. pneumoniae). Lung samples were collected from the large-scale pig farms in Jilin Province. The antimicrobial susceptibility and mouse lethality assay were carried out. K. pneumoniae isolate JP20 with high virulence and antibiotic resistance was chosen for whole-genome sequencing. The complete sequence of its genome was annotated, and the virulence and antibiotic resistance mechanism were analyzed. A total of 32 K. pneumoniae strains were isolated and tested for antibiotic resistance and pathogenicity. Among them, JP20 strain shown a high resistance to all tested antimicrobial agents and strong pathogenicity in mice (lethal dose of 1.35 × 1011CFU/ml). Sequencing of the multidrug-resistant and highly virulent K. pneumoniae JP20 strain revealed that the antibiotic resistance genes were mainly carried by an IncR plasmid. We speculate that extended-spectrum β-lactamases and loss of outer membrane porin OmpK36 play an important role in carbapenem antibiotic resistance. This plasmid contains a mosaic structure consisting of a large number of mobile elements. We found that an lncR plasmid carried by the JP20 strain may have evolved in pig farms through analyzing genome-wide analysis and it may have led to multidrug resistance in JP20 strain. It is speculated that the antibiotic resistance of K. pneumoniae in pig farms is mainly mediated by mobile elements (insertion sequences, transposons and plasmid). This data provides a basis for monitoring of the antibiotic resistance of K. pneumoniae and lays a foundation for further understanding of the genomic characteristics and antibiotic resistance mechanism of K. pneumoniae." @default.
• W4377097026 created "2023-05-20" @default.
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• W4377097026 date "2023-09-01" @default.
• W4377097026 modified "2023-09-27" @default.
• W4377097026 title "Analysis of an IncR plasmid carried by carbapenem-resistant Klebsiella pneumoniae: A survey of swine Klebsiella pneumoniae in Jilin Province" @default.
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• W4377097026 doi "https://doi.org/10.1016/j.jgar.2023.04.018" @default.
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