Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377102907> ?p ?o ?g. }
- W4377102907 endingPage "2045" @default.
- W4377102907 startingPage "2045" @default.
- W4377102907 abstract "Curcumin-loaded solid lipid nanoparticles (Cur-SLN) were prepared using medium- and long chain diacylglycerol (MLCD) or glycerol tripalmitate (TP) as lipid matrix and three kinds of surfactants including Tween 20 (T20), quillaja saponin (SQ) and rhamnolipid (Rha). The MLCD-based SLNs had a smaller size and lower surface charge than TP-SLNs with a Cur encapsulation efficiency of 87.54-95.32% and the Rha-based SLNs exhibited a small size but low stability to pH decreases and ionic strength. Thermal analysis and X-ray diffraction results confirmed that the SLNs with different lipid cores showed varying structures, melting and crystallization profiles. The emulsifiers slightly impacted the crystal polymorphism of MLCD-SLNs but largely influenced that of TP-SLNs. Meanwhile, the polymorphism transition was less significant for MLCD-SLNs, which accounted for the better stabilization of particle size and higher encapsulation efficiency of MLCD-SLNs during storage. In vitro studies showed that emulsifier formulation greatly impacted on the Cur bioavailability, whereby T20-SLNs showed much higher digestibility and bioavailability than that of SQ- and Rha-SLNs possibly due to the difference in the interfacial composition. Mathematical modeling analysis of the membrane release further confirmed that Cur was mainly released from the intestinal phase and T20-SLNs showed a faster release rate compared with other formulations. This work contributes to a better understanding of the performance of MLCD in lipophilic compound-loaded SLNs and has important implications for the rational design of lipid nanocarriers and in instructing their application in functional food products." @default.
- W4377102907 created "2023-05-20" @default.
- W4377102907 creator A5006575050 @default.
- W4377102907 creator A5019409019 @default.
- W4377102907 creator A5034493540 @default.
- W4377102907 creator A5052769403 @default.
- W4377102907 creator A5077940860 @default.
- W4377102907 creator A5087722547 @default.
- W4377102907 date "2023-05-18" @default.
- W4377102907 modified "2023-09-29" @default.
- W4377102907 title "Physicochemical and In Vitro Digestion Properties of Curcumin-Loaded Solid Lipid Nanoparticles with Different Solid Lipids and Emulsifiers" @default.
- W4377102907 cites W1995790138 @default.
- W4377102907 cites W2000352722 @default.
- W4377102907 cites W2017317942 @default.
- W4377102907 cites W2021274522 @default.
- W4377102907 cites W2027354098 @default.
- W4377102907 cites W2029069553 @default.
- W4377102907 cites W2052789439 @default.
- W4377102907 cites W2066772240 @default.
- W4377102907 cites W2079407952 @default.
- W4377102907 cites W2092719511 @default.
- W4377102907 cites W2136038958 @default.
- W4377102907 cites W2144733107 @default.
- W4377102907 cites W2158347094 @default.
- W4377102907 cites W2180909738 @default.
- W4377102907 cites W2403106583 @default.
- W4377102907 cites W2462196304 @default.
- W4377102907 cites W2559748264 @default.
- W4377102907 cites W2586725683 @default.
- W4377102907 cites W2737772033 @default.
- W4377102907 cites W2738652784 @default.
- W4377102907 cites W2794103340 @default.
- W4377102907 cites W2794777442 @default.
- W4377102907 cites W2800752654 @default.
- W4377102907 cites W2804655949 @default.
- W4377102907 cites W2805108881 @default.
- W4377102907 cites W2807456773 @default.
- W4377102907 cites W2897449778 @default.
- W4377102907 cites W2911782288 @default.
- W4377102907 cites W2924883751 @default.
- W4377102907 cites W2940549401 @default.
- W4377102907 cites W2945512042 @default.
- W4377102907 cites W2951089911 @default.
- W4377102907 cites W2962880895 @default.
- W4377102907 cites W2964737147 @default.
- W4377102907 cites W2966052837 @default.
- W4377102907 cites W2970066651 @default.
- W4377102907 cites W2995383448 @default.
- W4377102907 cites W3000201533 @default.
- W4377102907 cites W3000316303 @default.
- W4377102907 cites W3003210281 @default.
- W4377102907 cites W3005397058 @default.
- W4377102907 cites W3021076759 @default.
- W4377102907 cites W3022297987 @default.
- W4377102907 cites W3033596423 @default.
- W4377102907 cites W3033656287 @default.
- W4377102907 cites W3034008574 @default.
- W4377102907 cites W3036542916 @default.
- W4377102907 cites W3037003314 @default.
- W4377102907 cites W3088573482 @default.
- W4377102907 cites W3092592925 @default.
- W4377102907 cites W3099814332 @default.
- W4377102907 cites W3107687021 @default.
- W4377102907 cites W3119484308 @default.
- W4377102907 cites W3175757571 @default.
- W4377102907 cites W3202801781 @default.
- W4377102907 cites W3208462155 @default.
- W4377102907 cites W4210550278 @default.
- W4377102907 cites W4224075635 @default.
- W4377102907 cites W4281384263 @default.
- W4377102907 cites W4281700243 @default.
- W4377102907 cites W4286434269 @default.
- W4377102907 cites W4296285601 @default.
- W4377102907 cites W4297464137 @default.
- W4377102907 cites W4298003044 @default.
- W4377102907 cites W4308547946 @default.
- W4377102907 cites W4327737546 @default.
- W4377102907 cites W882663620 @default.
- W4377102907 doi "https://doi.org/10.3390/foods12102045" @default.
- W4377102907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37238863" @default.
- W4377102907 hasPublicationYear "2023" @default.
- W4377102907 type Work @default.
- W4377102907 citedByCount "0" @default.
- W4377102907 crossrefType "journal-article" @default.
- W4377102907 hasAuthorship W4377102907A5006575050 @default.
- W4377102907 hasAuthorship W4377102907A5019409019 @default.
- W4377102907 hasAuthorship W4377102907A5034493540 @default.
- W4377102907 hasAuthorship W4377102907A5052769403 @default.
- W4377102907 hasAuthorship W4377102907A5077940860 @default.
- W4377102907 hasAuthorship W4377102907A5087722547 @default.
- W4377102907 hasBestOaLocation W43771029071 @default.
- W4377102907 hasConcept C127413603 @default.
- W4377102907 hasConcept C147789679 @default.
- W4377102907 hasConcept C155672457 @default.
- W4377102907 hasConcept C171250308 @default.
- W4377102907 hasConcept C178790620 @default.
- W4377102907 hasConcept C181389837 @default.
- W4377102907 hasConcept C18150654 @default.