Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377103600> ?p ?o ?g. }
- W4377103600 endingPage "1531" @default.
- W4377103600 startingPage "1531" @default.
- W4377103600 abstract "The main aims of the study were to disclose the influence of the structure on the solubility, distribution and permeability of the parent substances, iproniazid (IPN), isoniazid (INZ) and isonicotinamide (iNCT), at 310.2 K and to evaluate how the presence of cyclodextrins (2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and methylated β-cyclodextrin (M-β-CD)) affects the distribution behavior and diffusion properties of a model pyridinecarboxamide derivative, iproniazid (IPN). The following order of decreasing the distribution and permeability coefficients was estimated: IPN > INZ > iNAM. A slight reduction of the distribution coefficients in the 1-octanol/buffer pH 7.4 and n-hexane/buffer pH 7.4 systems (more pronounced in the first system) was revealed. The extremely weak IPN/cyclodextrins complexes were estimated from the distribution experiments: KC(IPN/HP-β-CD) > KC(IPN/M-β-CD). The permeability coefficients of IPN through the lipophilic membrane-the PermeaPad barrier-were also measured with and without cyclodextrins in buffer solution. Permeability of iproniazid was increased in the presence of M-β-CD and reduced by HP-β-CD." @default.
- W4377103600 created "2023-05-20" @default.
- W4377103600 creator A5028469527 @default.
- W4377103600 creator A5030844068 @default.
- W4377103600 creator A5047728680 @default.
- W4377103600 date "2023-05-18" @default.
- W4377103600 modified "2023-09-26" @default.
- W4377103600 title "Modulation of Distribution and Diffusion through the Lipophilic Membrane with Cyclodextrins Exemplified by a Model Pyridinecarboxamide Derivative" @default.
- W4377103600 cites W1186552316 @default.
- W4377103600 cites W154885770 @default.
- W4377103600 cites W1964245308 @default.
- W4377103600 cites W1966132354 @default.
- W4377103600 cites W1977952516 @default.
- W4377103600 cites W1979103494 @default.
- W4377103600 cites W1979325424 @default.
- W4377103600 cites W1981216061 @default.
- W4377103600 cites W1998584026 @default.
- W4377103600 cites W2017227428 @default.
- W4377103600 cites W2027462520 @default.
- W4377103600 cites W2035468689 @default.
- W4377103600 cites W2039992676 @default.
- W4377103600 cites W2044585349 @default.
- W4377103600 cites W2046270074 @default.
- W4377103600 cites W2048175288 @default.
- W4377103600 cites W2052226480 @default.
- W4377103600 cites W2067305229 @default.
- W4377103600 cites W2068022739 @default.
- W4377103600 cites W2070332894 @default.
- W4377103600 cites W2073394985 @default.
- W4377103600 cites W2079727806 @default.
- W4377103600 cites W2085930246 @default.
- W4377103600 cites W2087979964 @default.
- W4377103600 cites W2092912556 @default.
- W4377103600 cites W2094452345 @default.
- W4377103600 cites W2096321754 @default.
- W4377103600 cites W2114254209 @default.
- W4377103600 cites W2117798770 @default.
- W4377103600 cites W2146872605 @default.
- W4377103600 cites W2289147608 @default.
- W4377103600 cites W2290286719 @default.
- W4377103600 cites W2318022372 @default.
- W4377103600 cites W2326124692 @default.
- W4377103600 cites W2401443574 @default.
- W4377103600 cites W2544024565 @default.
- W4377103600 cites W2558645758 @default.
- W4377103600 cites W2908629762 @default.
- W4377103600 cites W2955339250 @default.
- W4377103600 cites W3022814909 @default.
- W4377103600 cites W3110005030 @default.
- W4377103600 cites W4223528941 @default.
- W4377103600 cites W4311023950 @default.
- W4377103600 cites W765815668 @default.
- W4377103600 cites W3081893731 @default.
- W4377103600 doi "https://doi.org/10.3390/pharmaceutics15051531" @default.
- W4377103600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37242773" @default.
- W4377103600 hasPublicationYear "2023" @default.
- W4377103600 type Work @default.
- W4377103600 citedByCount "1" @default.
- W4377103600 countsByYear W43771036002023 @default.
- W4377103600 crossrefType "journal-article" @default.
- W4377103600 hasAuthorship W4377103600A5028469527 @default.
- W4377103600 hasAuthorship W4377103600A5030844068 @default.
- W4377103600 hasAuthorship W4377103600A5047728680 @default.
- W4377103600 hasBestOaLocation W43771036001 @default.
- W4377103600 hasConcept C120882062 @default.
- W4377103600 hasConcept C155574463 @default.
- W4377103600 hasConcept C178790620 @default.
- W4377103600 hasConcept C181199279 @default.
- W4377103600 hasConcept C185592680 @default.
- W4377103600 hasConcept C2776024655 @default.
- W4377103600 hasConcept C2777246417 @default.
- W4377103600 hasConcept C2778575451 @default.
- W4377103600 hasConcept C2779728014 @default.
- W4377103600 hasConcept C41625074 @default.
- W4377103600 hasConcept C50670333 @default.
- W4377103600 hasConcept C55493867 @default.
- W4377103600 hasConcept C71240020 @default.
- W4377103600 hasConceptScore W4377103600C120882062 @default.
- W4377103600 hasConceptScore W4377103600C155574463 @default.
- W4377103600 hasConceptScore W4377103600C178790620 @default.
- W4377103600 hasConceptScore W4377103600C181199279 @default.
- W4377103600 hasConceptScore W4377103600C185592680 @default.
- W4377103600 hasConceptScore W4377103600C2776024655 @default.
- W4377103600 hasConceptScore W4377103600C2777246417 @default.
- W4377103600 hasConceptScore W4377103600C2778575451 @default.
- W4377103600 hasConceptScore W4377103600C2779728014 @default.
- W4377103600 hasConceptScore W4377103600C41625074 @default.
- W4377103600 hasConceptScore W4377103600C50670333 @default.
- W4377103600 hasConceptScore W4377103600C55493867 @default.
- W4377103600 hasConceptScore W4377103600C71240020 @default.
- W4377103600 hasFunder F4320324099 @default.
- W4377103600 hasIssue "5" @default.
- W4377103600 hasLocation W43771036001 @default.
- W4377103600 hasLocation W43771036002 @default.
- W4377103600 hasOpenAccess W4377103600 @default.
- W4377103600 hasPrimaryLocation W43771036001 @default.
- W4377103600 hasRelatedWork W1679932693 @default.
- W4377103600 hasRelatedWork W1965489868 @default.