FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377104644> ?p ?o ?g. }

• W4377104644 endingPage "100780" @default.
• W4377104644 startingPage "100780" @default.
• W4377104644 abstract "ObjectivesFor nearly 3 years, the monoclonal antibody dupilumab has been approved in Germany for the treatment of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Although efficacy has been demonstrated in large double-blind, placebo-controlled clinical trials, few reports of real-world data on this therapy have been published to date.MethodsPatients with an indication for treatment with dupilumab for CRSwNP were included in the study and followed up every 3 months for a period of 1 year. At the baseline visit, demographic data, medical history, comorbidities, nasal polyp score, disease-related quality of life (SNOT-22), nasal congestion, and sense of smell (VAS and Sniffiń Sticks test) were recorded. In addition, total blood eosinophil counts and serum total IgE were measured. During follow-up, all of the described parameters and possible adverse events were recorded.ResultsEighty-one patients were enrolled in the study, of whom 68 patients were still receiving dupilumab after 1 year of follow-up. Eight patients discontinued therapy, with only 1 patient discontinuing due to severe side effects. The Polyp score decreased substantially during follow-up, and parameters for disease-related quality of life and sense of smell increased significantly. Total IgE levels decreased significantly, and eosinophils leveled off at baseline after an initial increase after three months of therapy. No clinical data could be identified to a priori predict a treatment response.ConclusionsDupilumab shows effectiveness and safety in the treatment of CRSwNP under real-world conditions. More research on systemic biomarkers and clinical parameters to predict treatment response is necessary." @default.
• W4377104644 created "2023-05-20" @default.
• W4377104644 creator A5033962209 @default.
• W4377104644 creator A5047627930 @default.
• W4377104644 creator A5052873504 @default.
• W4377104644 creator A5076600562 @default.
• W4377104644 creator A5077022030 @default.
• W4377104644 creator A5083202023 @default.
• W4377104644 date "2023-05-01" @default.
• W4377104644 modified "2023-10-06" @default.
• W4377104644 title "Real-world evidence for the effectiveness and safety of dupilumab in patients with CRSwNP after 1 year of therapy" @default.
• W4377104644 cites W2008188127 @default.
• W4377104644 cites W2016174655 @default.
• W4377104644 cites W2030674948 @default.
• W4377104644 cites W2033297002 @default.
• W4377104644 cites W2037890427 @default.
• W4377104644 cites W2051463089 @default.
• W4377104644 cites W2088353369 @default.
• W4377104644 cites W2104964526 @default.
• W4377104644 cites W2168515303 @default.
• W4377104644 cites W2228507300 @default.
• W4377104644 cites W2560688864 @default.
• W4377104644 cites W2620124785 @default.
• W4377104644 cites W2801587651 @default.
• W4377104644 cites W2805002966 @default.
• W4377104644 cites W2900857043 @default.
• W4377104644 cites W2947002828 @default.
• W4377104644 cites W2973437633 @default.
• W4377104644 cites W2993259418 @default.
• W4377104644 cites W2995438804 @default.
• W4377104644 cites W3034146395 @default.
• W4377104644 cites W3101343105 @default.
• W4377104644 cites W3126598211 @default.
• W4377104644 cites W3134224893 @default.
• W4377104644 cites W3136518486 @default.
• W4377104644 cites W3152988358 @default.
• W4377104644 cites W3163293937 @default.
• W4377104644 cites W3163989045 @default.
• W4377104644 cites W3164218797 @default.
• W4377104644 cites W3189475189 @default.
• W4377104644 cites W3201841185 @default.
• W4377104644 cites W3203577554 @default.
• W4377104644 cites W3207497551 @default.
• W4377104644 cites W3207588227 @default.
• W4377104644 cites W4211238948 @default.
• W4377104644 cites W4280620110 @default.
• W4377104644 cites W4283653389 @default.
• W4377104644 cites W4291015403 @default.
• W4377104644 cites W4293245940 @default.
• W4377104644 cites W4296356618 @default.
• W4377104644 cites W4306293634 @default.
• W4377104644 cites W4386008406 @default.
• W4377104644 doi "https://doi.org/10.1016/j.waojou.2023.100780" @default.
• W4377104644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37234094" @default.
• W4377104644 hasPublicationYear "2023" @default.
• W4377104644 type Work @default.
• W4377104644 citedByCount "1" @default.
• W4377104644 countsByYear W43771046442023 @default.
• W4377104644 crossrefType "journal-article" @default.
• W4377104644 hasAuthorship W4377104644A5033962209 @default.
• W4377104644 hasAuthorship W4377104644A5047627930 @default.
• W4377104644 hasAuthorship W4377104644A5052873504 @default.
• W4377104644 hasAuthorship W4377104644A5076600562 @default.
• W4377104644 hasAuthorship W4377104644A5077022030 @default.
• W4377104644 hasAuthorship W4377104644A5083202023 @default.
• W4377104644 hasBestOaLocation W43771046441 @default.
• W4377104644 hasConcept C126322002 @default.
• W4377104644 hasConcept C141071460 @default.
• W4377104644 hasConcept C142724271 @default.
• W4377104644 hasConcept C159110408 @default.
• W4377104644 hasConcept C197934379 @default.
• W4377104644 hasConcept C204787440 @default.
• W4377104644 hasConcept C27081682 @default.
• W4377104644 hasConcept C2776042228 @default.
• W4377104644 hasConcept C2777037409 @default.
• W4377104644 hasConcept C2777844070 @default.
• W4377104644 hasConcept C2778311950 @default.
• W4377104644 hasConcept C2779134260 @default.
• W4377104644 hasConcept C2779824493 @default.
• W4377104644 hasConcept C2779951463 @default.
• W4377104644 hasConcept C2781390199 @default.
• W4377104644 hasConcept C535046627 @default.
• W4377104644 hasConcept C71924100 @default.
• W4377104644 hasConceptScore W4377104644C126322002 @default.
• W4377104644 hasConceptScore W4377104644C141071460 @default.
• W4377104644 hasConceptScore W4377104644C142724271 @default.
• W4377104644 hasConceptScore W4377104644C159110408 @default.
• W4377104644 hasConceptScore W4377104644C197934379 @default.
• W4377104644 hasConceptScore W4377104644C204787440 @default.
• W4377104644 hasConceptScore W4377104644C27081682 @default.
• W4377104644 hasConceptScore W4377104644C2776042228 @default.
• W4377104644 hasConceptScore W4377104644C2777037409 @default.
• W4377104644 hasConceptScore W4377104644C2777844070 @default.
• W4377104644 hasConceptScore W4377104644C2778311950 @default.
• W4377104644 hasConceptScore W4377104644C2779134260 @default.
• W4377104644 hasConceptScore W4377104644C2779824493 @default.
• W4377104644 hasConceptScore W4377104644C2779951463 @default.
• W4377104644 hasConceptScore W4377104644C2781390199 @default.

• next