FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377115375> ?p ?o ?g. }

• W4377115375 endingPage "e621" @default.
• W4377115375 startingPage "e611" @default.
• W4377115375 abstract "Aims Perineural invasion (PNI) is a special type of metastasis of several cancers and has been reported as being a factor for poor prognosis in colorectal carcinoma. However, investigations of PNI in only rectal cancer and a comprehensive analysis combining meta-analyses with real-world case studies remain lacking. Materials and methods First, articles from 2000 to 2020 concerning the relationship between PNI and rectal cancer prognoses and clinical features were meta-analysed. Subsequently, we carried out a retrospective analysis of 312 rectal cancer cases that underwent radical surgery in the real world. The incidence of PNI and the relationship between PNI and prognosis, as well as clinicopathological factors, were investigated. Results The incidence of PNI was 23.09% and 33.01% in the meta-analysis and clinical cases, respectively. PNI occurred as early as stage I (2.94%). Moreover, neoadjuvant therapy significantly reduced the PNI-positive rate (20.34% versus 26.54%). Both meta-analysis and real-world clinical case studies suggested that PNI-positive patients had poorer prognoses than PNI-negative patients. We established an effective risk model consisting of T stage, differentiation and lymphovascular invasion to predict PNI in rectal cancer. Conclusion PNI is a poor prognostic factor for rectal cancer and could occur even in stage I. Additionally, neoadjuvant therapy could sufficiently reduce the PNI-positive rate. T stage, lymphovascular invasion and differentiation grade were independent risk factors for PNI and the risk model that included these factors could predict the probability of PNI." @default.
• W4377115375 created "2023-05-20" @default.
• W4377115375 creator A5006024692 @default.
• W4377115375 creator A5015942602 @default.
• W4377115375 creator A5033070027 @default.
• W4377115375 creator A5039904219 @default.
• W4377115375 creator A5047832617 @default.
• W4377115375 creator A5049295143 @default.
• W4377115375 creator A5052596568 @default.
• W4377115375 creator A5055587956 @default.
• W4377115375 creator A5060487990 @default.
• W4377115375 creator A5064550210 @default.
• W4377115375 creator A5064820931 @default.
• W4377115375 date "2023-10-01" @default.
• W4377115375 modified "2023-10-12" @default.
• W4377115375 title "The Incidence and Prognosis Value of Perineural Invasion in Rectal Carcinoma: From Meta-Analyses and Real-World Clinical Pathological Features" @default.
• W4377115375 cites W1490833936 @default.
• W4377115375 cites W1532654778 @default.
• W4377115375 cites W1981886643 @default.
• W4377115375 cites W1994277526 @default.
• W4377115375 cites W2014776577 @default.
• W4377115375 cites W2025126749 @default.
• W4377115375 cites W2030430663 @default.
• W4377115375 cites W2056991745 @default.
• W4377115375 cites W2072090020 @default.
• W4377115375 cites W2074685734 @default.
• W4377115375 cites W2074703669 @default.
• W4377115375 cites W2078799416 @default.
• W4377115375 cites W2079167500 @default.
• W4377115375 cites W2084139018 @default.
• W4377115375 cites W2088073445 @default.
• W4377115375 cites W2106014206 @default.
• W4377115375 cites W2123377696 @default.
• W4377115375 cites W2129925362 @default.
• W4377115375 cites W2137471713 @default.
• W4377115375 cites W2149407433 @default.
• W4377115375 cites W2406358661 @default.
• W4377115375 cites W2509381107 @default.
• W4377115375 cites W2525142738 @default.
• W4377115375 cites W2531206999 @default.
• W4377115375 cites W2569391944 @default.
• W4377115375 cites W2583965456 @default.
• W4377115375 cites W2774405145 @default.
• W4377115375 cites W2791039358 @default.
• W4377115375 cites W2792203605 @default.
• W4377115375 cites W2889486159 @default.
• W4377115375 cites W2912546405 @default.
• W4377115375 cites W2944365186 @default.
• W4377115375 cites W2999344851 @default.
• W4377115375 cites W3012413426 @default.
• W4377115375 cites W3038392370 @default.
• W4377115375 cites W3128646645 @default.
• W4377115375 cites W4239620521 @default.
• W4377115375 doi "https://doi.org/10.1016/j.clon.2023.05.008" @default.
• W4377115375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37263883" @default.
• W4377115375 hasPublicationYear "2023" @default.
• W4377115375 type Work @default.
• W4377115375 citedByCount "0" @default.
• W4377115375 crossrefType "journal-article" @default.
• W4377115375 hasAuthorship W4377115375A5006024692 @default.
• W4377115375 hasAuthorship W4377115375A5015942602 @default.
• W4377115375 hasAuthorship W4377115375A5033070027 @default.
• W4377115375 hasAuthorship W4377115375A5039904219 @default.
• W4377115375 hasAuthorship W4377115375A5047832617 @default.
• W4377115375 hasAuthorship W4377115375A5049295143 @default.
• W4377115375 hasAuthorship W4377115375A5052596568 @default.
• W4377115375 hasAuthorship W4377115375A5055587956 @default.
• W4377115375 hasAuthorship W4377115375A5060487990 @default.
• W4377115375 hasAuthorship W4377115375A5064550210 @default.
• W4377115375 hasAuthorship W4377115375A5064820931 @default.
• W4377115375 hasConcept C120665830 @default.
• W4377115375 hasConcept C121332964 @default.
• W4377115375 hasConcept C121608353 @default.
• W4377115375 hasConcept C126322002 @default.
• W4377115375 hasConcept C143998085 @default.
• W4377115375 hasConcept C146357865 @default.
• W4377115375 hasConcept C151730666 @default.
• W4377115375 hasConcept C207886595 @default.
• W4377115375 hasConcept C2777154038 @default.
• W4377115375 hasConcept C2778740770 @default.
• W4377115375 hasConcept C2779013556 @default.
• W4377115375 hasConcept C2780091936 @default.
• W4377115375 hasConcept C2991871042 @default.
• W4377115375 hasConcept C50440223 @default.
• W4377115375 hasConcept C526805850 @default.
• W4377115375 hasConcept C61511704 @default.
• W4377115375 hasConcept C71924100 @default.
• W4377115375 hasConcept C86803240 @default.
• W4377115375 hasConcept C90924648 @default.
• W4377115375 hasConceptScore W4377115375C120665830 @default.
• W4377115375 hasConceptScore W4377115375C121332964 @default.
• W4377115375 hasConceptScore W4377115375C121608353 @default.
• W4377115375 hasConceptScore W4377115375C126322002 @default.
• W4377115375 hasConceptScore W4377115375C143998085 @default.
• W4377115375 hasConceptScore W4377115375C146357865 @default.
• W4377115375 hasConceptScore W4377115375C151730666 @default.
• W4377115375 hasConceptScore W4377115375C207886595 @default.
• W4377115375 hasConceptScore W4377115375C2777154038 @default.

• next