Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377137200> ?p ?o ?g. }
- W4377137200 abstract "The exact mechanism controlling cell growth remains a grand challenge in developmental biology and regenerative medicine. The Drosophila wing disc tissue serves as an ideal biological model to study mechanisms involved in growth regulation. Most existing computational models for studying tissue growth focus specifically on either chemical signals or mechanical forces. Here we developed a multiscale chemical-mechanical model to investigate the growth regulation mechanism based on the dynamics of a morphogen gradient. By comparing the spatial distribution of dividing cells and the overall tissue shape obtained in model simulations with experimental data of the wing disc, it is shown that the size of the domain of the Dpp morphogen is critical in determining tissue size and shape. A larger tissue size with a faster growth rate and more symmetric shape can be achieved if the Dpp gradient spreads in a larger domain. Together with Dpp absorbance at the peripheral zone, the feedback regulation that downregulates Dpp receptors on the cell membrane allows for further spreading of the morphogen away from its source region, resulting in prolonged tissue growth at a more spatially homogeneous growth rate." @default.
- W4377137200 created "2023-05-21" @default.
- W4377137200 creator A5000234159 @default.
- W4377137200 creator A5021027542 @default.
- W4377137200 creator A5021171831 @default.
- W4377137200 creator A5043260247 @default.
- W4377137200 creator A5069586059 @default.
- W4377137200 creator A5087549934 @default.
- W4377137200 date "2023-05-20" @default.
- W4377137200 modified "2023-10-14" @default.
- W4377137200 title "A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth" @default.
- W4377137200 cites W1512153219 @default.
- W4377137200 cites W1517998622 @default.
- W4377137200 cites W1660449597 @default.
- W4377137200 cites W1663371441 @default.
- W4377137200 cites W1863585495 @default.
- W4377137200 cites W1949173079 @default.
- W4377137200 cites W1960461233 @default.
- W4377137200 cites W1963272169 @default.
- W4377137200 cites W1967487044 @default.
- W4377137200 cites W1968660175 @default.
- W4377137200 cites W1974673184 @default.
- W4377137200 cites W1986414916 @default.
- W4377137200 cites W1990351024 @default.
- W4377137200 cites W1991100707 @default.
- W4377137200 cites W1991113069 @default.
- W4377137200 cites W1991894655 @default.
- W4377137200 cites W1998523488 @default.
- W4377137200 cites W1999008437 @default.
- W4377137200 cites W2000618372 @default.
- W4377137200 cites W2002364726 @default.
- W4377137200 cites W2010567868 @default.
- W4377137200 cites W2014168964 @default.
- W4377137200 cites W2016727307 @default.
- W4377137200 cites W2018311787 @default.
- W4377137200 cites W2018776114 @default.
- W4377137200 cites W2037038224 @default.
- W4377137200 cites W2037766522 @default.
- W4377137200 cites W2042297889 @default.
- W4377137200 cites W2046831616 @default.
- W4377137200 cites W2054464790 @default.
- W4377137200 cites W2060248455 @default.
- W4377137200 cites W2061220010 @default.
- W4377137200 cites W2063482980 @default.
- W4377137200 cites W2068909410 @default.
- W4377137200 cites W2069435294 @default.
- W4377137200 cites W2071199204 @default.
- W4377137200 cites W2084131634 @default.
- W4377137200 cites W2090683259 @default.
- W4377137200 cites W2093028734 @default.
- W4377137200 cites W2105472771 @default.
- W4377137200 cites W2113695281 @default.
- W4377137200 cites W2114351911 @default.
- W4377137200 cites W2117073266 @default.
- W4377137200 cites W2117602643 @default.
- W4377137200 cites W2119549820 @default.
- W4377137200 cites W2122969640 @default.
- W4377137200 cites W2131453448 @default.
- W4377137200 cites W2132199624 @default.
- W4377137200 cites W2138222765 @default.
- W4377137200 cites W2141334319 @default.
- W4377137200 cites W2155154349 @default.
- W4377137200 cites W2159094603 @default.
- W4377137200 cites W2171157655 @default.
- W4377137200 cites W2177485263 @default.
- W4377137200 cites W2193977748 @default.
- W4377137200 cites W2234549232 @default.
- W4377137200 cites W2269140001 @default.
- W4377137200 cites W2397821752 @default.
- W4377137200 cites W2417278137 @default.
- W4377137200 cites W2440232853 @default.
- W4377137200 cites W2540898869 @default.
- W4377137200 cites W2565644806 @default.
- W4377137200 cites W2601679020 @default.
- W4377137200 cites W2730111555 @default.
- W4377137200 cites W2768337145 @default.
- W4377137200 cites W2769424033 @default.
- W4377137200 cites W2770684632 @default.
- W4377137200 cites W2810398043 @default.
- W4377137200 cites W2923643932 @default.
- W4377137200 cites W2952599113 @default.
- W4377137200 cites W3035962243 @default.
- W4377137200 cites W4319290968 @default.
- W4377137200 doi "https://doi.org/10.1038/s41540-023-00278-5" @default.
- W4377137200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37210381" @default.
- W4377137200 hasPublicationYear "2023" @default.
- W4377137200 type Work @default.
- W4377137200 citedByCount "0" @default.
- W4377137200 crossrefType "journal-article" @default.
- W4377137200 hasAuthorship W4377137200A5000234159 @default.
- W4377137200 hasAuthorship W4377137200A5021027542 @default.
- W4377137200 hasAuthorship W4377137200A5021171831 @default.
- W4377137200 hasAuthorship W4377137200A5043260247 @default.
- W4377137200 hasAuthorship W4377137200A5069586059 @default.
- W4377137200 hasAuthorship W4377137200A5087549934 @default.
- W4377137200 hasBestOaLocation W43771372001 @default.
- W4377137200 hasConcept C104317684 @default.
- W4377137200 hasConcept C121332964 @default.
- W4377137200 hasConcept C12554922 @default.
- W4377137200 hasConcept C183074962 @default.