Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377139569> ?p ?o ?g. }
- W4377139569 abstract "Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. LIM domain and actin-binding protein 1 (LIMA1), as an important actin cytoskeletal regulator, was initially thought to be a tumor suppressor frequently downregulated in epithelial tumors. Importantly, the deficiency of LIMA1 may be responsible for dysregulated cytoskeletal dynamics, altered cell motility and disrupted cell-cell adhesion, which promote tumor proliferation, invasion and migration. As research progresses, the roles of LIMA1 extend from cytoskeletal dynamics and cell motility to cell division, gene regulation, apical extrusion, angiogenesis, cellular metabolism and lipid metabolism. However, the expression of LIMA1 in malignant tumors and its mechanism of action have not yet been elucidated, and many problems and challenges remain to be addressed. Therefore, this review systematically describes the structure and biological functions of LIMA1 and explores its expression and regulatory mechanism in malignant tumors, and further discusses its clinical value and therapeutic prospects." @default.
- W4377139569 created "2023-05-21" @default.
- W4377139569 creator A5001351060 @default.
- W4377139569 creator A5022967729 @default.
- W4377139569 creator A5029338358 @default.
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- W4377139569 creator A5047305117 @default.
- W4377139569 creator A5072851963 @default.
- W4377139569 creator A5085181392 @default.
- W4377139569 creator A5089966579 @default.
- W4377139569 date "2023-05-19" @default.
- W4377139569 modified "2023-09-27" @default.
- W4377139569 title "Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers" @default.
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