FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377140347> ?p ?o ?g. }

• W4377140347 abstract "Amyloid formation is a hallmark of various neurodegenerative disorders. In this contribution, energy landscapes are explored for various hexapeptides that are known to form amyloids. Heat capacity (C V ) analysis at low temperature for these hexapeptides reveals that the low energy structures contributing to the first heat capacity feature above a threshold temperature exhibit a variety of backbone conformations for amyloid forming monomers. The corresponding control sequences do not exhibit such structural polymorphism, as diagnosed via end-to-end distance and a dihedral angle defined for the monomer. A similar heat capacity analysis for dimer conformations obtained using basin-hopping global optimisation, shows clear features in end-to-end distance versus dihedral correlation plots, where amyloid-forming sequences exhibit a preference for larger end-to-end distances and larger positive dihedrals. These results hold for sequences taken from tau, amylin, insulin A chain, a de-novo designed peptide, and various control sequences. While there is a little overall correlation between the aggregation propensity and the temperature at which the low-temperature C V feature occurs, further analysis suggests that the amyloid forming sequences exhibit the key C V feature at a lower temperature compared to control sequences derived from the same protein." @default.
• W4377140347 created "2023-05-21" @default.
• W4377140347 creator A5014057135 @default.
• W4377140347 creator A5022301289 @default.
• W4377140347 date "2023-05-19" @default.
• W4377140347 modified "2023-09-30" @default.
• W4377140347 title "Energy landscapes and heat capacity signatures for monomers and dimers of amyloid forming hexapeptides" @default.
• W4377140347 cites W1489708565 @default.
• W4377140347 cites W1566214213 @default.
• W4377140347 cites W1570643690 @default.
• W4377140347 cites W1963871440 @default.
• W4377140347 cites W1964610252 @default.
• W4377140347 cites W1965822959 @default.
• W4377140347 cites W1968280815 @default.
• W4377140347 cites W1972798923 @default.
• W4377140347 cites W1973697766 @default.
• W4377140347 cites W1975170550 @default.
• W4377140347 cites W1980947284 @default.
• W4377140347 cites W1985121447 @default.
• W4377140347 cites W1990592765 @default.
• W4377140347 cites W1996450030 @default.
• W4377140347 cites W1999347494 @default.
• W4377140347 cites W2004751437 @default.
• W4377140347 cites W2007236469 @default.
• W4377140347 cites W2012108346 @default.
• W4377140347 cites W2012455318 @default.
• W4377140347 cites W2013785414 @default.
• W4377140347 cites W2018662121 @default.
• W4377140347 cites W2019521349 @default.
• W4377140347 cites W2024568067 @default.
• W4377140347 cites W2027839322 @default.
• W4377140347 cites W2031430816 @default.
• W4377140347 cites W2032697213 @default.
• W4377140347 cites W2036563840 @default.
• W4377140347 cites W2039100280 @default.
• W4377140347 cites W2041119019 @default.
• W4377140347 cites W2044597283 @default.
• W4377140347 cites W2051434435 @default.
• W4377140347 cites W2051459678 @default.
• W4377140347 cites W2051669046 @default.
• W4377140347 cites W2051763485 @default.
• W4377140347 cites W2058214407 @default.
• W4377140347 cites W2062430286 @default.
• W4377140347 cites W2064367582 @default.
• W4377140347 cites W2064959295 @default.
• W4377140347 cites W2065251521 @default.
• W4377140347 cites W2067924797 @default.
• W4377140347 cites W2069110016 @default.
• W4377140347 cites W2074288620 @default.
• W4377140347 cites W2082381159 @default.
• W4377140347 cites W2084219899 @default.
• W4377140347 cites W2085411125 @default.
• W4377140347 cites W2086108910 @default.
• W4377140347 cites W2087357689 @default.
• W4377140347 cites W2088615896 @default.
• W4377140347 cites W2089491263 @default.
• W4377140347 cites W2091370335 @default.
• W4377140347 cites W2093861673 @default.
• W4377140347 cites W2100630099 @default.
• W4377140347 cites W2103083136 @default.
• W4377140347 cites W2104417000 @default.
• W4377140347 cites W2104849621 @default.
• W4377140347 cites W2107853929 @default.
• W4377140347 cites W2116063507 @default.
• W4377140347 cites W2117537971 @default.
• W4377140347 cites W2118233996 @default.
• W4377140347 cites W2122427541 @default.
• W4377140347 cites W2123976234 @default.
• W4377140347 cites W2124325047 @default.
• W4377140347 cites W2129507901 @default.
• W4377140347 cites W2138480068 @default.
• W4377140347 cites W2140389961 @default.
• W4377140347 cites W2142366168 @default.
• W4377140347 cites W2142692094 @default.
• W4377140347 cites W2146554687 @default.
• W4377140347 cites W2157909659 @default.
• W4377140347 cites W2161163255 @default.
• W4377140347 cites W2161605421 @default.
• W4377140347 cites W2162575609 @default.
• W4377140347 cites W2163210644 @default.
• W4377140347 cites W2165319412 @default.
• W4377140347 cites W2169528473 @default.
• W4377140347 cites W2203031395 @default.
• W4377140347 cites W2332712348 @default.
• W4377140347 cites W2598196934 @default.
• W4377140347 cites W3104575368 @default.
• W4377140347 cites W3104767865 @default.
• W4377140347 cites W3105621768 @default.
• W4377140347 cites W4210522538 @default.
• W4377140347 cites W4375864666 @default.
• W4377140347 doi "https://doi.org/10.1101/2023.05.17.541223" @default.
• W4377140347 hasPublicationYear "2023" @default.
• W4377140347 type Work @default.
• W4377140347 citedByCount "0" @default.
• W4377140347 crossrefType "posted-content" @default.
• W4377140347 hasAuthorship W4377140347A5014057135 @default.
• W4377140347 hasAuthorship W4377140347A5022301289 @default.
• W4377140347 hasBestOaLocation W43771403471 @default.
• W4377140347 hasConcept C112887158 @default.
• W4377140347 hasConcept C121332964 @default.

• next