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- W4377141730 abstract "Antibacterial resistance is a global health crisis that is primarily due to the overuse and misuse of antimicrobial drugs. Therefore, the pharmaceutical industry is continuously striving to develop new antibacterial agents. Herein, we have reported stereoselective synthesis of dispiropyrrolidinyl oxindole derivatives using 1,3-dipolar cycloaddition reaction, between arylidene indanone derivatives as dipolarophile and azomethine ylides formed in situ from isatin and sarcosine in a multicomponent reaction (MCR) mode. The reaction condition was optimized and the absolute configuration of the dispiro products was determined using NMR spectroscopic data and confirmed from the single crystal X-ray crystallography. The newly synthesized spiro derivatives showed good to moderate in vitro antibacterial efficiency against six bacterial species. The preliminary in silico studies revealed that these dispiro derivatives have a potential binding affinity towards the penicillin-binding protein-3 and they could be used as a template for future antibacterial drug discovery." @default.
- W4377141730 created "2023-05-21" @default.
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- W4377141730 date "2023-09-01" @default.
- W4377141730 modified "2023-10-03" @default.
- W4377141730 title "Stereoselective synthesis of dispiropyrrolidinyl oxindole derivatives and evaluation of their antibacterial efficacy" @default.
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- W4377141730 doi "https://doi.org/10.1016/j.molstruc.2023.135808" @default.
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