Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377142502> ?p ?o ?g. }
- W4377142502 endingPage "2014" @default.
- W4377142502 startingPage "1997" @default.
- W4377142502 abstract "Cutaneous basal and squamous cell carcinoma reflect the first and second most common type of non-melanoma skin cancer, respectively. Especially cutaneous squamous cell carcinoma has the tendency to metastasize, finally resulting in a rather poor prognosis. Therapeutic options comprise surgery, radiation therapy, and a systemic or targeted chemotherapy. There are some good treatment results, but overall, the response rate of newly developed drugs is still modest. Drug repurposing represents an alternative approach where already available and clinically approved substances are used, which originally intended for other clinical benefits. In this context, we tested the effect of the naturally occurring polyphenolic aldehyde (±) gossypol with concentrations between 1 and 5 µM on the invasive squamous cell carcinoma cell line SCL-1 and normal human epidermal keratinocytes. Gossypol treatment up to 96 h resulted in a selective cytotoxicity of SCL-1 cells (IC50: 1.7 µM, 96 h) compared with normal keratinocytes (IC50: ≥ 5.4 µM, 96 h) which is mediated by mitochondrial dysfunction and finally leading to necroptotic cell death. Taken together, gossypol shows a high potential as an alternative anticancer drug for the treatment of cutaneous squamous cell carcinoma." @default.
- W4377142502 created "2023-05-21" @default.
- W4377142502 creator A5003601873 @default.
- W4377142502 creator A5006765832 @default.
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- W4377142502 creator A5067315505 @default.
- W4377142502 creator A5084274549 @default.
- W4377142502 creator A5090317832 @default.
- W4377142502 date "2023-05-21" @default.
- W4377142502 modified "2023-10-01" @default.
- W4377142502 title "Involvement of necroptosis in the selective toxicity of the natural compound (±) gossypol on squamous skin cancer cells in vitro" @default.
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- W4377142502 doi "https://doi.org/10.1007/s00204-023-03516-1" @default.