FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377164037> ?p ?o ?g. }

• W4377164037 endingPage "2977" @default.
• W4377164037 startingPage "2966" @default.
• W4377164037 abstract "Abstract Background and Aims To examine the decongestive effect of the sodium-glucose cotransporter 2 inhibitor dapagliflozin compared to the thiazide-like diuretic metolazone in patients hospitalized for heart failure and resistant to treatment with intravenous furosemide. Methods and results A multi-centre, open-label, randomized, and active-comparator trial. Patients were randomized to dapagliflozin 10 mg once daily or metolazone 5–10 mg once daily for a 3-day treatment period, with follow-up for primary and secondary endpoints until day 5 (96 h). The primary endpoint was a diuretic effect, assessed by change in weight (kg). Secondary endpoints included a change in pulmonary congestion (lung ultrasound), loop diuretic efficiency (weight change per 40 mg of furosemide), and a volume assessment score. 61 patients were randomized. The mean (±standard deviation) cumulative dose of furosemide at 96 h was 977 (±492) mg in the dapagliflozin group and 704 (±428) mg in patients assigned to metolazone. The mean (±standard deviation) decrease in weight at 96 h was 3.0 (2.5) kg with dapagliflozin compared to 3.6 (2.0) kg with metolazone [mean difference 0.65, 95% confidence interval (CI) −0.12,1.41 kg; P = 0.11]. Loop diuretic efficiency was less with dapagliflozin than with metolazone [mean 0.15 (0.12) vs. 0.25 (0.19); difference −0.08, 95% CI −0.17,0.01 kg; P = 0.10]. Changes in pulmonary congestion and volume assessment score were similar between treatments. Decreases in plasma sodium and potassium and increases in urea and creatinine were smaller with dapagliflozin than with metolazone. Serious adverse events were similar between treatments. Conclusion In patients with heart failure and loop diuretic resistance, dapagliflozin was not more effective at relieving congestion than metolazone. Patients assigned to dapagliflozin received a larger cumulative dose of furosemide but experienced less biochemical upset than those assigned to metolazone. Trial registration ClinicalTrials.gov Identifier: NCT04860011" @default.
• W4377164037 created "2023-05-21" @default.
• W4377164037 creator A5000133151 @default.
• W4377164037 creator A5002237171 @default.
• W4377164037 creator A5002852509 @default.
• W4377164037 creator A5007021966 @default.
• W4377164037 creator A5007964446 @default.
• W4377164037 creator A5008918644 @default.
• W4377164037 creator A5013729622 @default.
• W4377164037 creator A5015794888 @default.
• W4377164037 creator A5018432247 @default.
• W4377164037 creator A5021225266 @default.
• W4377164037 creator A5027213857 @default.
• W4377164037 creator A5032500917 @default.
• W4377164037 creator A5036013897 @default.
• W4377164037 creator A5036659787 @default.
• W4377164037 creator A5037392377 @default.
• W4377164037 creator A5037748733 @default.
• W4377164037 creator A5038622452 @default.
• W4377164037 creator A5043991721 @default.
• W4377164037 creator A5044941050 @default.
• W4377164037 creator A5055441634 @default.
• W4377164037 creator A5061437401 @default.
• W4377164037 creator A5061857615 @default.
• W4377164037 creator A5067990677 @default.
• W4377164037 creator A5073781406 @default.
• W4377164037 date "2023-05-21" @default.
• W4377164037 modified "2023-10-09" @default.
• W4377164037 title "Dapagliflozin vs. metolazone in heart failure resistant to loop diuretics" @default.
• W4377164037 cites W2013448178 @default.
• W4377164037 cites W2054965274 @default.
• W4377164037 cites W2082244841 @default.
• W4377164037 cites W2104547465 @default.
• W4377164037 cites W2119875370 @default.
• W4377164037 cites W2139359396 @default.
• W4377164037 cites W2165668878 @default.
• W4377164037 cites W2169560588 @default.
• W4377164037 cites W2242382501 @default.
• W4377164037 cites W2596201728 @default.
• W4377164037 cites W2763866789 @default.
• W4377164037 cites W2907983377 @default.
• W4377164037 cites W2911478519 @default.
• W4377164037 cites W2911792351 @default.
• W4377164037 cites W2972839323 @default.
• W4377164037 cites W2977962205 @default.
• W4377164037 cites W2995550955 @default.
• W4377164037 cites W3000647500 @default.
• W4377164037 cites W3002325057 @default.
• W4377164037 cites W3010099281 @default.
• W4377164037 cites W3011186745 @default.
• W4377164037 cites W3081091856 @default.
• W4377164037 cites W3193598686 @default.
• W4377164037 cites W3213007181 @default.
• W4377164037 cites W4200213577 @default.
• W4377164037 cites W4237637677 @default.
• W4377164037 cites W4293353625 @default.
• W4377164037 cites W4293872386 @default.
• W4377164037 cites W4306684314 @default.
• W4377164037 cites W4308294088 @default.
• W4377164037 cites W4309908777 @default.
• W4377164037 cites W4366083844 @default.
• W4377164037 doi "https://doi.org/10.1093/eurheartj/ehad341" @default.
• W4377164037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37210742" @default.
• W4377164037 hasPublicationYear "2023" @default.
• W4377164037 type Work @default.
• W4377164037 citedByCount "7" @default.
• W4377164037 countsByYear W43771640372023 @default.
• W4377164037 crossrefType "journal-article" @default.
• W4377164037 hasAuthorship W4377164037A5000133151 @default.
• W4377164037 hasAuthorship W4377164037A5002237171 @default.
• W4377164037 hasAuthorship W4377164037A5002852509 @default.
• W4377164037 hasAuthorship W4377164037A5007021966 @default.
• W4377164037 hasAuthorship W4377164037A5007964446 @default.
• W4377164037 hasAuthorship W4377164037A5008918644 @default.
• W4377164037 hasAuthorship W4377164037A5013729622 @default.
• W4377164037 hasAuthorship W4377164037A5015794888 @default.
• W4377164037 hasAuthorship W4377164037A5018432247 @default.
• W4377164037 hasAuthorship W4377164037A5021225266 @default.
• W4377164037 hasAuthorship W4377164037A5027213857 @default.
• W4377164037 hasAuthorship W4377164037A5032500917 @default.
• W4377164037 hasAuthorship W4377164037A5036013897 @default.
• W4377164037 hasAuthorship W4377164037A5036659787 @default.
• W4377164037 hasAuthorship W4377164037A5037392377 @default.
• W4377164037 hasAuthorship W4377164037A5037748733 @default.
• W4377164037 hasAuthorship W4377164037A5038622452 @default.
• W4377164037 hasAuthorship W4377164037A5043991721 @default.
• W4377164037 hasAuthorship W4377164037A5044941050 @default.
• W4377164037 hasAuthorship W4377164037A5055441634 @default.
• W4377164037 hasAuthorship W4377164037A5061437401 @default.
• W4377164037 hasAuthorship W4377164037A5061857615 @default.
• W4377164037 hasAuthorship W4377164037A5067990677 @default.
• W4377164037 hasAuthorship W4377164037A5073781406 @default.
• W4377164037 hasBestOaLocation W43771640371 @default.
• W4377164037 hasConcept C126322002 @default.
• W4377164037 hasConcept C126894567 @default.
• W4377164037 hasConcept C134018914 @default.
• W4377164037 hasConcept C168563851 @default.
• W4377164037 hasConcept C203092338 @default.

• next