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- W4377194927 abstract "Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose of 100 mg/kg resulted in significant tumor growth inhibition by 60–61% on 7th, 9th and 15th days of tumor development. Course administration of GK-1 in doses of 10 mk/kg from 2nd to 15 th day of tumor development resulted in significant tumor growth inhibition by 57,8 %. Metastasis inhibition index (MII) of gemcitabine was 75,8 %. MII of GK-1 in doses of 10 mg/kg or 30 mg/kg was 44,9 % and 47,7 % accordingly. It was shown that GK-1 in studied range of doses exerts antimetastatic activity." @default.
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- W4377194927 date "2023-05-10" @default.
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- W4377194927 title "Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice" @default.
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- W4377194927 doi "https://doi.org/10.37489/2587-7836-2023-1-45-50" @default.
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