Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377206144> ?p ?o ?g. }
- W4377206144 abstract "Abstract Cellular senescence is known to play a role in age-related skin function deterioration which potentially influences longevity. Here, a two-step phenotypic screening was performed to identify senotherapeutic peptides, leading to the identification of Peptide (Pep) 14. Pep 14 effectively decreased human dermal fibroblast senescence burden induced by Hutchinson-Gilford Progeria Syndrome (HGPS), chronological aging, ultraviolet-B radiation (UVB), and etoposide treatment, without inducing significant toxicity. Pep 14 functions via modulation of PP2A, an understudied holoenzyme that promotes genomic stability and is involved in DNA repair and senescence pathways. At the single-cell level, Pep 14 modulates genes that prevent senescence progression by arresting the cell cycle and enhancing DNA repair, which consequently reduce the number of cells progressing to late senescence. When applied on aged ex vivo skin, Pep 14 promoted a healthy skin phenotype with structural and molecular resemblance to young ex vivo skin, decreased the expression of senescence markers, including SASP, and reduced the DNA methylation age. In summary, this work shows the safe reduction of the biological age of ex vivo human skins by a senomorphic peptide." @default.
- W4377206144 created "2023-05-22" @default.
- W4377206144 creator A5005897688 @default.
- W4377206144 creator A5009312725 @default.
- W4377206144 creator A5016282630 @default.
- W4377206144 creator A5023458394 @default.
- W4377206144 creator A5024047935 @default.
- W4377206144 creator A5031255772 @default.
- W4377206144 creator A5041524355 @default.
- W4377206144 creator A5042140942 @default.
- W4377206144 creator A5063952242 @default.
- W4377206144 creator A5067763938 @default.
- W4377206144 creator A5074236037 @default.
- W4377206144 creator A5084536916 @default.
- W4377206144 creator A5088113315 @default.
- W4377206144 creator A5089262018 @default.
- W4377206144 date "2023-05-22" @default.
- W4377206144 modified "2023-10-04" @default.
- W4377206144 title "Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models" @default.
- W4377206144 cites W1156636126 @default.
- W4377206144 cites W1533710382 @default.
- W4377206144 cites W189289305 @default.
- W4377206144 cites W1965771422 @default.
- W4377206144 cites W1974047233 @default.
- W4377206144 cites W1977362098 @default.
- W4377206144 cites W1989277387 @default.
- W4377206144 cites W2035618305 @default.
- W4377206144 cites W2054917860 @default.
- W4377206144 cites W2060770087 @default.
- W4377206144 cites W2060964204 @default.
- W4377206144 cites W2061893502 @default.
- W4377206144 cites W2067542143 @default.
- W4377206144 cites W2088566849 @default.
- W4377206144 cites W2101870168 @default.
- W4377206144 cites W2104908670 @default.
- W4377206144 cites W2119883345 @default.
- W4377206144 cites W2120201159 @default.
- W4377206144 cites W2121091193 @default.
- W4377206144 cites W2126525177 @default.
- W4377206144 cites W2131271579 @default.
- W4377206144 cites W2134459412 @default.
- W4377206144 cites W2134526812 @default.
- W4377206144 cites W2141973975 @default.
- W4377206144 cites W2146581693 @default.
- W4377206144 cites W2156793564 @default.
- W4377206144 cites W2159675211 @default.
- W4377206144 cites W2169456326 @default.
- W4377206144 cites W2179438025 @default.
- W4377206144 cites W2190545194 @default.
- W4377206144 cites W2224886002 @default.
- W4377206144 cites W2266290735 @default.
- W4377206144 cites W2290981040 @default.
- W4377206144 cites W2291827855 @default.
- W4377206144 cites W2296527999 @default.
- W4377206144 cites W2324067007 @default.
- W4377206144 cites W2409978204 @default.
- W4377206144 cites W2550469153 @default.
- W4377206144 cites W2583634043 @default.
- W4377206144 cites W2599353531 @default.
- W4377206144 cites W2607214955 @default.
- W4377206144 cites W2619582233 @default.
- W4377206144 cites W2739062306 @default.
- W4377206144 cites W2748768502 @default.
- W4377206144 cites W2750509325 @default.
- W4377206144 cites W2752676842 @default.
- W4377206144 cites W2768033029 @default.
- W4377206144 cites W2803105783 @default.
- W4377206144 cites W2809283005 @default.
- W4377206144 cites W2883262856 @default.
- W4377206144 cites W2885857238 @default.
- W4377206144 cites W2889003443 @default.
- W4377206144 cites W2897805491 @default.
- W4377206144 cites W2900569176 @default.
- W4377206144 cites W2905232298 @default.
- W4377206144 cites W2913600879 @default.
- W4377206144 cites W2913976105 @default.
- W4377206144 cites W2916020270 @default.
- W4377206144 cites W2922056276 @default.
- W4377206144 cites W2946310536 @default.
- W4377206144 cites W2949100461 @default.
- W4377206144 cites W2949177718 @default.
- W4377206144 cites W2972011940 @default.
- W4377206144 cites W2989720469 @default.
- W4377206144 cites W3000364256 @default.
- W4377206144 cites W3013381082 @default.
- W4377206144 cites W3040912464 @default.
- W4377206144 cites W3080707378 @default.
- W4377206144 cites W3083569321 @default.
- W4377206144 cites W3099399372 @default.
- W4377206144 cites W3108996799 @default.
- W4377206144 cites W3120913371 @default.
- W4377206144 cites W3126843737 @default.
- W4377206144 cites W3149804071 @default.
- W4377206144 cites W3151266872 @default.
- W4377206144 cites W3164692211 @default.
- W4377206144 cites W3213771556 @default.
- W4377206144 cites W4213012034 @default.
- W4377206144 cites W4225567851 @default.
- W4377206144 cites W4233698560 @default.
- W4377206144 cites W4285097943 @default.