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- W4377214355 endingPage "12" @default.
- W4377214355 startingPage "1" @default.
- W4377214355 abstract "Abstract The type I insulin-like growth factor receptor (IGF-IR) plays multiple roles in several cancers and increased circulating levels of insulin-like growth factor-I (IGF-I) are associated with increased risk of breast, colon, and prostate cancers. Because IGF-II and insulin signal via the insulin receptor (IR) to stimulate the growth of cancer cells, inhibition of IR might be necessary to totally disrupt the action of IGFs and their receptors. This review describes the well-recognized roles of IGF-IR in driving the malignant phenotype, examines the evidence that perhaps IR should also be targeted to inhibit the effects of the IGF ligands and insulin in cancer, describes the strategies to disrupt IGF signaling in cancer, and highlights some key issues that need to be considered as clinical trials targeting IGF-IR proceed. [Mol Cancer Ther 2007;6(1):1–12]" @default.
- W4377214355 created "2023-05-22" @default.
- W4377214355 creator A5030715622 @default.
- W4377214355 creator A5066098544 @default.
- W4377214355 date "2007-01-01" @default.
- W4377214355 modified "2023-10-16" @default.
- W4377214355 title "Disrupting insulin-like growth factor signaling as a potential cancer therapy" @default.
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