FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377220521> ?p ?o ?g. }

• W4377220521 endingPage "93" @default.
• W4377220521 startingPage "77" @default.
• W4377220521 abstract "Infection with the SARS-CoV-2 virus (COVID-19 disease) can cause a wide range of clinical situations – from an asymptomatic state to fatal outcomes. In cases of serious clinical manifestations, the underlying mechanisms involve a number of immune cells and stromal cells as well as their products such as pro-inflammatory interleukin-6 and tumour necrosis factor-alpha that ultimately cause the cytokine storm. The situation of overproduction of pro-inflammatory cytokines is somewhat similar to, though in a mild form, health conditions in obesity and related metabolic disorders like type-2 diabetes, which are also considered important risk factors for severe illness in COVID-19. Interestingly, neutrophils perhaps play a significant role in this pathogenesis. On the other hand, it is thought that COVID-19-related critical illness is associated with pathological hyperactivity of the complement system and coagulopathy. Although the precise molecular interactions between the complement and coagulation systems are not clear, we observe an intimate cross-talk between these two systems in critically ill COVID-19 patients. It is believed that both of these biological systems are connected with the cytokine storm in severe COVID-19 disease and actively participate in this vicious cycle. In order to hinder the pathological progression of COVID-19, a number of anticoagulation agents and complement inhibitors have been used with varying success. Among these drugs, low molecular weight heparin enoxaparin, factor Xa inhibitor apixaban, and complement C5 inhibitor eculizumab have been commonly used in patients with COVID-19. Our overall experience might help us in the future to tackle any such conditions." @default.
• W4377220521 created "2023-05-23" @default.
• W4377220521 creator A5025425997 @default.
• W4377220521 creator A5033168539 @default.
• W4377220521 creator A5052968867 @default.
• W4377220521 creator A5062040958 @default.
• W4377220521 date "2023-01-01" @default.
• W4377220521 modified "2023-09-24" @default.
• W4377220521 title "Prognostic Significance of the Coagulation and Complement Systems in Critical COVID-19 Infection" @default.
• W4377220521 cites W1520991027 @default.
• W4377220521 cites W2034351496 @default.
• W4377220521 cites W2140500533 @default.
• W4377220521 cites W2152799956 @default.
• W4377220521 cites W2800513588 @default.
• W4377220521 cites W2898080189 @default.
• W4377220521 cites W2910405468 @default.
• W4377220521 cites W2970751378 @default.
• W4377220521 cites W3014573995 @default.
• W4377220521 cites W3016123694 @default.
• W4377220521 cites W3020883035 @default.
• W4377220521 cites W3022757001 @default.
• W4377220521 cites W3028989873 @default.
• W4377220521 cites W3031410640 @default.
• W4377220521 cites W3036207809 @default.
• W4377220521 cites W3038003308 @default.
• W4377220521 cites W3039546911 @default.
• W4377220521 cites W3040537993 @default.
• W4377220521 cites W3041988256 @default.
• W4377220521 cites W3045035401 @default.
• W4377220521 cites W3046588153 @default.
• W4377220521 cites W3047345450 @default.
• W4377220521 cites W3048259608 @default.
• W4377220521 cites W3080304426 @default.
• W4377220521 cites W3081502886 @default.
• W4377220521 cites W3082912310 @default.
• W4377220521 cites W3084456691 @default.
• W4377220521 cites W3085958090 @default.
• W4377220521 cites W3087090615 @default.
• W4377220521 cites W3091839106 @default.
• W4377220521 cites W3091911950 @default.
• W4377220521 cites W3092357584 @default.
• W4377220521 cites W3093430741 @default.
• W4377220521 cites W3093482635 @default.
• W4377220521 cites W3096274861 @default.
• W4377220521 cites W3096430081 @default.
• W4377220521 cites W3097903491 @default.
• W4377220521 cites W3102127170 @default.
• W4377220521 cites W3109283769 @default.
• W4377220521 cites W3110020451 @default.
• W4377220521 cites W3120028189 @default.
• W4377220521 cites W3128579949 @default.
• W4377220521 cites W3129602411 @default.
• W4377220521 cites W3134386391 @default.
• W4377220521 cites W3136016654 @default.
• W4377220521 cites W3136792553 @default.
• W4377220521 cites W3151985943 @default.
• W4377220521 cites W3164431582 @default.
• W4377220521 cites W3170112469 @default.
• W4377220521 cites W3180268234 @default.
• W4377220521 cites W3185014427 @default.
• W4377220521 cites W3186056773 @default.
• W4377220521 cites W3193704441 @default.
• W4377220521 cites W3198241409 @default.
• W4377220521 cites W3200339764 @default.
• W4377220521 cites W3212628873 @default.
• W4377220521 cites W3215021001 @default.
• W4377220521 cites W4200137171 @default.
• W4377220521 cites W4200556622 @default.
• W4377220521 cites W4200557111 @default.
• W4377220521 cites W4214555045 @default.
• W4377220521 cites W4283573930 @default.
• W4377220521 cites W4283752406 @default.
• W4377220521 cites W4285679074 @default.
• W4377220521 cites W4293211780 @default.
• W4377220521 cites W4295084104 @default.
• W4377220521 doi "https://doi.org/10.14712/23362936.2023.7" @default.
• W4377220521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37212129" @default.
• W4377220521 hasPublicationYear "2023" @default.
• W4377220521 type Work @default.
• W4377220521 citedByCount "1" @default.
• W4377220521 countsByYear W43772205212023 @default.
• W4377220521 crossrefType "journal-article" @default.
• W4377220521 hasAuthorship W4377220521A5025425997 @default.
• W4377220521 hasAuthorship W4377220521A5033168539 @default.
• W4377220521 hasAuthorship W4377220521A5052968867 @default.
• W4377220521 hasAuthorship W4377220521A5062040958 @default.
• W4377220521 hasBestOaLocation W43772205211 @default.
• W4377220521 hasConcept C111684460 @default.
• W4377220521 hasConcept C126322002 @default.
• W4377220521 hasConcept C203014093 @default.
• W4377220521 hasConcept C2777637130 @default.
• W4377220521 hasConcept C2777991916 @default.
• W4377220521 hasConcept C2779134260 @default.
• W4377220521 hasConcept C2779559532 @default.
• W4377220521 hasConcept C2779936836 @default.
• W4377220521 hasConcept C2780942790 @default.
• W4377220521 hasConcept C3008058167 @default.
• W4377220521 hasConcept C524204448 @default.

• next