FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377221046> ?p ?o ?g. }

• W4377221046 abstract "Radiation injury is common after radiotherapy for head and neck cancer. Radiotherapy can reshape the immune microenvironment and cause immunosuppression, including dysregulation of immune checkpoints (ICs). However, the relationship between oral ICs expression after radiation and the development of second primary tumors is unclear.Clinical specimens of second primary oral squamous cell carcinoma after radiotherapy (s-OSCC) and primary OSCC (p-OSCC) were collected. The expression and prognostic value of PD-1, VISTA, and TIM-3 were analyzed using immunohistochemistry. To further clarify the relationship between radiation and ICs alteration, a rat model was constructed to explore the spatiotemporal changes of ICs in the oral mucosa after radiation.In carcinoma tissue, the expression of TIM-3 was higher in s-OSCC than in p-OSCC, while the expression of PD-1 and VISTA was similar between the groups. In para-carcinoma tissue, the expression of PD-1, VISTA, and TIM-3 was higher in s-OSCC. High ICs expression was associated with poor survival. In the rat model, ICs were locally upregulated in the irradiated tongue. Moreover, there was a bystander effect, in which the ICs were also upregulated in the unirradiated site.Radiation may upregulate ICs expression in oral mucosa and contribute to the development of s-OSCC." @default.
• W4377221046 created "2023-05-23" @default.
• W4377221046 creator A5030432386 @default.
• W4377221046 creator A5032236956 @default.
• W4377221046 creator A5032974852 @default.
• W4377221046 creator A5036102861 @default.
• W4377221046 creator A5060432160 @default.
• W4377221046 creator A5071715760 @default.
• W4377221046 creator A5073296484 @default.
• W4377221046 date "2023-05-22" @default.
• W4377221046 modified "2023-10-15" @default.
• W4377221046 title "Radiotherapy upregulated immune checkpoints contribute to the development of second primary <scp>OSCC</scp>" @default.
• W4377221046 cites W1533545305 @default.
• W4377221046 cites W1583511338 @default.
• W4377221046 cites W1771952094 @default.
• W4377221046 cites W2014433188 @default.
• W4377221046 cites W2037287757 @default.
• W4377221046 cites W2040429159 @default.
• W4377221046 cites W2066671159 @default.
• W4377221046 cites W2109271488 @default.
• W4377221046 cites W2137750991 @default.
• W4377221046 cites W2137790827 @default.
• W4377221046 cites W2531326360 @default.
• W4377221046 cites W2602541598 @default.
• W4377221046 cites W2613363084 @default.
• W4377221046 cites W2736411979 @default.
• W4377221046 cites W2767542870 @default.
• W4377221046 cites W2791780442 @default.
• W4377221046 cites W2792292919 @default.
• W4377221046 cites W2809428848 @default.
• W4377221046 cites W2811438356 @default.
• W4377221046 cites W2951153979 @default.
• W4377221046 cites W2955294253 @default.
• W4377221046 cites W2981193841 @default.
• W4377221046 cites W3087384818 @default.
• W4377221046 cites W3115988948 @default.
• W4377221046 cites W3129357027 @default.
• W4377221046 cites W3155639992 @default.
• W4377221046 cites W3200966513 @default.
• W4377221046 cites W3202201767 @default.
• W4377221046 cites W2026850952 @default.
• W4377221046 doi "https://doi.org/10.1111/odi.14621" @default.
• W4377221046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37213085" @default.
• W4377221046 hasPublicationYear "2023" @default.
• W4377221046 type Work @default.
• W4377221046 citedByCount "1" @default.
• W4377221046 countsByYear W43772210462023 @default.
• W4377221046 crossrefType "journal-article" @default.
• W4377221046 hasAuthorship W4377221046A5030432386 @default.
• W4377221046 hasAuthorship W4377221046A5032236956 @default.
• W4377221046 hasAuthorship W4377221046A5032974852 @default.
• W4377221046 hasAuthorship W4377221046A5036102861 @default.
• W4377221046 hasAuthorship W4377221046A5060432160 @default.
• W4377221046 hasAuthorship W4377221046A5071715760 @default.
• W4377221046 hasAuthorship W4377221046A5073296484 @default.
• W4377221046 hasConcept C104317684 @default.
• W4377221046 hasConcept C121608353 @default.
• W4377221046 hasConcept C126322002 @default.
• W4377221046 hasConcept C127561419 @default.
• W4377221046 hasConcept C142724271 @default.
• W4377221046 hasConcept C203014093 @default.
• W4377221046 hasConcept C204232928 @default.
• W4377221046 hasConcept C2776107976 @default.
• W4377221046 hasConcept C2776530083 @default.
• W4377221046 hasConcept C2779409057 @default.
• W4377221046 hasConcept C2780252810 @default.
• W4377221046 hasConcept C502942594 @default.
• W4377221046 hasConcept C509974204 @default.
• W4377221046 hasConcept C55493867 @default.
• W4377221046 hasConcept C71924100 @default.
• W4377221046 hasConcept C86803240 @default.
• W4377221046 hasConcept C8891405 @default.
• W4377221046 hasConceptScore W4377221046C104317684 @default.
• W4377221046 hasConceptScore W4377221046C121608353 @default.
• W4377221046 hasConceptScore W4377221046C126322002 @default.
• W4377221046 hasConceptScore W4377221046C127561419 @default.
• W4377221046 hasConceptScore W4377221046C142724271 @default.
• W4377221046 hasConceptScore W4377221046C203014093 @default.
• W4377221046 hasConceptScore W4377221046C204232928 @default.
• W4377221046 hasConceptScore W4377221046C2776107976 @default.
• W4377221046 hasConceptScore W4377221046C2776530083 @default.
• W4377221046 hasConceptScore W4377221046C2779409057 @default.
• W4377221046 hasConceptScore W4377221046C2780252810 @default.
• W4377221046 hasConceptScore W4377221046C502942594 @default.
• W4377221046 hasConceptScore W4377221046C509974204 @default.
• W4377221046 hasConceptScore W4377221046C55493867 @default.
• W4377221046 hasConceptScore W4377221046C71924100 @default.
• W4377221046 hasConceptScore W4377221046C86803240 @default.
• W4377221046 hasConceptScore W4377221046C8891405 @default.
• W4377221046 hasFunder F4320321001 @default.
• W4377221046 hasLocation W43772210461 @default.
• W4377221046 hasLocation W43772210462 @default.
• W4377221046 hasOpenAccess W4377221046 @default.
• W4377221046 hasPrimaryLocation W43772210461 @default.
• W4377221046 hasRelatedWork W1817566737 @default.
• W4377221046 hasRelatedWork W1965612933 @default.
• W4377221046 hasRelatedWork W2380931084 @default.
• W4377221046 hasRelatedWork W2771066073 @default.
• W4377221046 hasRelatedWork W2971748217 @default.
• W4377221046 hasRelatedWork W3046338067 @default.

• next