Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377221235> ?p ?o ?g. }
- W4377221235 endingPage "7085" @default.
- W4377221235 startingPage "7070" @default.
- W4377221235 abstract "The chemokine system is a key player in the functioning of the immune system and a sought-after target for drug candidates. The number of experimental structures of chemokines in complex with chemokine receptors has increased rapidly over the past few years, providing essential information for rational development of chemokine receptor ligands. Here, we perform a comparative analysis of all chemokine–chemokine receptor structures, with the aim of characterizing the molecular recognition processes and highlighting the relationships between chemokine structures and functional processes. The structures show conserved interaction patterns between the chemokine core and the receptor N-terminus, while interactions near ECL2 display subfamily-specific features. Detailed analyses of the interactions of the chemokine N-terminal domain in the 7TM cavities reveal activation mechanisms for CCR5, CCR2, and CXCR2 and a mechanism for biased agonism in CCR1." @default.
- W4377221235 created "2023-05-23" @default.
- W4377221235 creator A5005741666 @default.
- W4377221235 creator A5006919535 @default.
- W4377221235 date "2023-05-22" @default.
- W4377221235 modified "2023-09-25" @default.
- W4377221235 title "Structural Insights into Molecular Recognition and Receptor Activation in Chemokine–Chemokine Receptor Complexes" @default.
- W4377221235 cites W1833104430 @default.
- W4377221235 cites W1922705469 @default.
- W4377221235 cites W1933465244 @default.
- W4377221235 cites W1964083898 @default.
- W4377221235 cites W1987888973 @default.
- W4377221235 cites W1988778953 @default.
- W4377221235 cites W1997340548 @default.
- W4377221235 cites W1999048558 @default.
- W4377221235 cites W1999153777 @default.
- W4377221235 cites W2002489008 @default.
- W4377221235 cites W2002994195 @default.
- W4377221235 cites W2004471062 @default.
- W4377221235 cites W2010593183 @default.
- W4377221235 cites W2015198542 @default.
- W4377221235 cites W2019879894 @default.
- W4377221235 cites W2020087881 @default.
- W4377221235 cites W2026850235 @default.
- W4377221235 cites W2029479572 @default.
- W4377221235 cites W2031005807 @default.
- W4377221235 cites W2031618958 @default.
- W4377221235 cites W2050947403 @default.
- W4377221235 cites W2074603792 @default.
- W4377221235 cites W2080335255 @default.
- W4377221235 cites W2089062549 @default.
- W4377221235 cites W2097632784 @default.
- W4377221235 cites W2116714781 @default.
- W4377221235 cites W2122890687 @default.
- W4377221235 cites W2128845370 @default.
- W4377221235 cites W2132674776 @default.
- W4377221235 cites W2146933058 @default.
- W4377221235 cites W2152815720 @default.
- W4377221235 cites W2154560913 @default.
- W4377221235 cites W2167007363 @default.
- W4377221235 cites W2168193216 @default.
- W4377221235 cites W2331370620 @default.
- W4377221235 cites W2509928882 @default.
- W4377221235 cites W2560722699 @default.
- W4377221235 cites W2587556779 @default.
- W4377221235 cites W2617691667 @default.
- W4377221235 cites W2713710610 @default.
- W4377221235 cites W2797069917 @default.
- W4377221235 cites W2805385738 @default.
- W4377221235 cites W2809303314 @default.
- W4377221235 cites W2955866354 @default.
- W4377221235 cites W2979332239 @default.
- W4377221235 cites W2984761660 @default.
- W4377221235 cites W2996405687 @default.
- W4377221235 cites W2996952632 @default.
- W4377221235 cites W3001205381 @default.
- W4377221235 cites W3016181183 @default.
- W4377221235 cites W3035444582 @default.
- W4377221235 cites W3038311311 @default.
- W4377221235 cites W3172249076 @default.
- W4377221235 cites W3181744232 @default.
- W4377221235 cites W4200309699 @default.
- W4377221235 cites W4206757674 @default.
- W4377221235 cites W4244603190 @default.
- W4377221235 cites W4280598523 @default.
- W4377221235 cites W4283218951 @default.
- W4377221235 cites W4283696625 @default.
- W4377221235 cites W4285083066 @default.
- W4377221235 cites W4318934232 @default.
- W4377221235 doi "https://doi.org/10.1021/acs.jmedchem.3c00352" @default.
- W4377221235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37212620" @default.
- W4377221235 hasPublicationYear "2023" @default.
- W4377221235 type Work @default.
- W4377221235 citedByCount "2" @default.
- W4377221235 countsByYear W43772212352023 @default.
- W4377221235 crossrefType "journal-article" @default.
- W4377221235 hasAuthorship W4377221235A5005741666 @default.
- W4377221235 hasAuthorship W4377221235A5006919535 @default.
- W4377221235 hasConcept C12823836 @default.
- W4377221235 hasConcept C128879288 @default.
- W4377221235 hasConcept C129013479 @default.
- W4377221235 hasConcept C13164669 @default.
- W4377221235 hasConcept C13373296 @default.
- W4377221235 hasConcept C170493617 @default.
- W4377221235 hasConcept C179661763 @default.
- W4377221235 hasConcept C185592680 @default.
- W4377221235 hasConcept C186382791 @default.
- W4377221235 hasConcept C206615009 @default.
- W4377221235 hasConcept C29146819 @default.
- W4377221235 hasConcept C48001867 @default.
- W4377221235 hasConcept C55493867 @default.
- W4377221235 hasConcept C84913492 @default.
- W4377221235 hasConcept C86803240 @default.
- W4377221235 hasConcept C94205230 @default.
- W4377221235 hasConcept C95444343 @default.
- W4377221235 hasConceptScore W4377221235C12823836 @default.
- W4377221235 hasConceptScore W4377221235C128879288 @default.
- W4377221235 hasConceptScore W4377221235C129013479 @default.