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- W4377221284 abstract "Introduction Lennox-Gastaut syndrome (LGS) is a severe childhood-onset epileptic encephalopathy, characterized by multiple seizure types, generalized slow spike-and-wave complexes in the EEG, and cognitive impairment. Seizures in LGS are typically resistant to treatment with antiseizure medications (ASMs). Tonic/atonic (‘drop’) seizures are of particular concern, due to their liability to cause physical injury.Areas covered We summarize evidence for current and emerging ASMs for the treatment of seizures in LGS. The review focuses on findings from randomized, double-blind, placebo-controlled trials (RDBCTs). For ASMs for which no double-blind trials were identified, lower quality evidence was considered. Novel pharmacological agents currently undergoing investigation for the treatment of LGS are also briefly discussed.Expert opinion Evidence from RDBCTs supports the use of cannabidiol, clobazam, felbamate, fenfluramine, lamotrigine, rufinamide, and topiramate as adjunct treatments for drop seizures. Percentage decreases in drop seizure frequency ranged from 68.3% with high-dose clobazam to 14.8% with topiramate. Valproate continues to be considered the first-line treatment, despite the absence of RDBCTs specifically in LGS. Most individuals with LGS will require treatment with multiple ASMs. Treatment decisions should be individualized and take into account adverse effects, comorbidities, general quality of life, and drug interactions, as well as individual efficacy." @default.
- W4377221284 created "2023-05-23" @default.
- W4377221284 creator A5018555892 @default.
- W4377221284 creator A5040670651 @default.
- W4377221284 creator A5075142495 @default.
- W4377221284 date "2023-06-05" @default.
- W4377221284 modified "2023-09-29" @default.
- W4377221284 title "Current and emerging pharmacotherapy for the treatment of Lennox-Gastaut syndrome" @default.
- W4377221284 cites W125678881 @default.
- W4377221284 cites W1579311408 @default.
- W4377221284 cites W1671458509 @default.
- W4377221284 cites W1776168885 @default.
- W4377221284 cites W1857838684 @default.
- W4377221284 cites W1950387798 @default.
- W4377221284 cites W1966601175 @default.
- W4377221284 cites W1980866137 @default.
- W4377221284 cites W1981495453 @default.
- W4377221284 cites W1989254265 @default.
- W4377221284 cites W1990156650 @default.
- W4377221284 cites W1990288905 @default.
- W4377221284 cites W2001340786 @default.
- W4377221284 cites W2002053318 @default.
- W4377221284 cites W2003199554 @default.
- W4377221284 cites W2004399349 @default.
- W4377221284 cites W2004858786 @default.
- W4377221284 cites W2009083741 @default.
- W4377221284 cites W2014672556 @default.
- W4377221284 cites W2019333928 @default.
- W4377221284 cites W2020497106 @default.
- W4377221284 cites W2020906184 @default.
- W4377221284 cites W2025153671 @default.
- W4377221284 cites W2029490757 @default.
- W4377221284 cites W2033122718 @default.
- W4377221284 cites W2038383322 @default.
- W4377221284 cites W2042011859 @default.
- W4377221284 cites W2048532324 @default.
- W4377221284 cites W2050055596 @default.
- W4377221284 cites W2050502246 @default.
- W4377221284 cites W2053258270 @default.
- W4377221284 cites W2056061463 @default.
- W4377221284 cites W2056141314 @default.
- W4377221284 cites W2061631774 @default.
- W4377221284 cites W2062647434 @default.
- W4377221284 cites W2071339887 @default.
- W4377221284 cites W2072014832 @default.
- W4377221284 cites W2074486762 @default.
- W4377221284 cites W2074784640 @default.
- W4377221284 cites W2082629538 @default.
- W4377221284 cites W2083969921 @default.
- W4377221284 cites W2090654997 @default.
- W4377221284 cites W2090910256 @default.
- W4377221284 cites W2093392404 @default.
- W4377221284 cites W2093868906 @default.
- W4377221284 cites W2101515546 @default.
- W4377221284 cites W2108725527 @default.
- W4377221284 cites W2112144930 @default.
- W4377221284 cites W2117519195 @default.
- W4377221284 cites W2119186079 @default.
- W4377221284 cites W2120567388 @default.
- W4377221284 cites W2125106774 @default.
- W4377221284 cites W2126691800 @default.
- W4377221284 cites W2137728866 @default.
- W4377221284 cites W2140155039 @default.
- W4377221284 cites W2144996528 @default.
- W4377221284 cites W2157909788 @default.
- W4377221284 cites W2159439874 @default.
- W4377221284 cites W2165165265 @default.
- W4377221284 cites W2169966598 @default.
- W4377221284 cites W2239952012 @default.
- W4377221284 cites W2332716921 @default.
- W4377221284 cites W2340499140 @default.
- W4377221284 cites W2430173125 @default.
- W4377221284 cites W2501850254 @default.
- W4377221284 cites W2588643061 @default.
- W4377221284 cites W2596598505 @default.
- W4377221284 cites W2614859754 @default.
- W4377221284 cites W2736048503 @default.
- W4377221284 cites W2744115661 @default.
- W4377221284 cites W2767480397 @default.
- W4377221284 cites W2785059893 @default.
- W4377221284 cites W2790416725 @default.
- W4377221284 cites W2804921146 @default.
- W4377221284 cites W2811592420 @default.
- W4377221284 cites W2894484912 @default.
- W4377221284 cites W2898611747 @default.
- W4377221284 cites W2907498716 @default.
- W4377221284 cites W2912654638 @default.
- W4377221284 cites W2914333425 @default.
- W4377221284 cites W2915210550 @default.
- W4377221284 cites W2936410494 @default.
- W4377221284 cites W2936734228 @default.
- W4377221284 cites W2937160316 @default.
- W4377221284 cites W2985094843 @default.
- W4377221284 cites W2989586610 @default.
- W4377221284 cites W2995607922 @default.
- W4377221284 cites W3008442486 @default.
- W4377221284 cites W3030769523 @default.
- W4377221284 cites W3031017926 @default.