Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377221470> ?p ?o ?g. }
- W4377221470 abstract "Nicotinamide metabolism is important in carcinogenesis. Nicotinamide affects the cellular methyl pool, thus affecting DNA and histone methylation and gene expression. Cancer cells have increased expression of nicotinamide N-methyl transferase (NNMT), the key enzyme in nicotinamide metabolism. NNMT contributes to tumor angiogenesis. Overexpression of NNMT is associated with poorer prognosis in cancers. Additionally, NNMT can contribute to cancer-associated morbidities, such as cancer-associated thrombosis. 1-methylnicotinamide (1-MNA), a metabolite of nicotinamide, has anti-inflammatory and antithrombotic effects. Therefore, targeting NNMT can affect both carcinogenesis and cancer-associated morbidities. Several antitumor drugs have been shown to inhibit NNMT expression in cancer cells. Implementing these drugs to reverse NNMT effects in addition to 1-MNA supplementation has the potential to prevent cancer-associated thrombosis through various mechanisms." @default.
- W4377221470 created "2023-05-23" @default.
- W4377221470 creator A5043880029 @default.
- W4377221470 creator A5045795947 @default.
- W4377221470 creator A5071325269 @default.
- W4377221470 creator A5091990475 @default.
- W4377221470 date "2023-05-22" @default.
- W4377221470 modified "2023-09-25" @default.
- W4377221470 title "Nicotinamide N-methyl transferase and cancer-associated thrombosis: insights to prevention and management" @default.
- W4377221470 cites W138950541 @default.
- W4377221470 cites W1492041605 @default.
- W4377221470 cites W1743065782 @default.
- W4377221470 cites W1831033366 @default.
- W4377221470 cites W1899099918 @default.
- W4377221470 cites W1916110267 @default.
- W4377221470 cites W1964365809 @default.
- W4377221470 cites W1964561434 @default.
- W4377221470 cites W1977017159 @default.
- W4377221470 cites W1978021879 @default.
- W4377221470 cites W1988122231 @default.
- W4377221470 cites W1988556846 @default.
- W4377221470 cites W1991940012 @default.
- W4377221470 cites W1994099917 @default.
- W4377221470 cites W1997815012 @default.
- W4377221470 cites W2005281127 @default.
- W4377221470 cites W2005997562 @default.
- W4377221470 cites W2010394923 @default.
- W4377221470 cites W2012105970 @default.
- W4377221470 cites W2013710547 @default.
- W4377221470 cites W2017070089 @default.
- W4377221470 cites W2020866377 @default.
- W4377221470 cites W2026514054 @default.
- W4377221470 cites W2028316525 @default.
- W4377221470 cites W2028922093 @default.
- W4377221470 cites W2030944573 @default.
- W4377221470 cites W2034370209 @default.
- W4377221470 cites W2038124783 @default.
- W4377221470 cites W2041387950 @default.
- W4377221470 cites W2046099392 @default.
- W4377221470 cites W2051959397 @default.
- W4377221470 cites W2053832057 @default.
- W4377221470 cites W2070361497 @default.
- W4377221470 cites W2070633611 @default.
- W4377221470 cites W2081275593 @default.
- W4377221470 cites W2083533688 @default.
- W4377221470 cites W2084060660 @default.
- W4377221470 cites W2086641174 @default.
- W4377221470 cites W2087060887 @default.
- W4377221470 cites W2090929924 @default.
- W4377221470 cites W2109492293 @default.
- W4377221470 cites W2112992618 @default.
- W4377221470 cites W2116330166 @default.
- W4377221470 cites W2118671268 @default.
- W4377221470 cites W2121511357 @default.
- W4377221470 cites W2121927401 @default.
- W4377221470 cites W2142983041 @default.
- W4377221470 cites W2143343444 @default.
- W4377221470 cites W2147012307 @default.
- W4377221470 cites W2150640476 @default.
- W4377221470 cites W2153762942 @default.
- W4377221470 cites W2161427454 @default.
- W4377221470 cites W2174991333 @default.
- W4377221470 cites W2257325807 @default.
- W4377221470 cites W2320365161 @default.
- W4377221470 cites W2322031839 @default.
- W4377221470 cites W2415689568 @default.
- W4377221470 cites W2472843965 @default.
- W4377221470 cites W2521525385 @default.
- W4377221470 cites W2554203775 @default.
- W4377221470 cites W2568572531 @default.
- W4377221470 cites W2572350087 @default.
- W4377221470 cites W2579290699 @default.
- W4377221470 cites W2585564425 @default.
- W4377221470 cites W2612955161 @default.
- W4377221470 cites W2615517553 @default.
- W4377221470 cites W2760433216 @default.
- W4377221470 cites W2788350317 @default.
- W4377221470 cites W2801676455 @default.
- W4377221470 cites W2809161827 @default.
- W4377221470 cites W2886297408 @default.
- W4377221470 cites W2886940457 @default.
- W4377221470 cites W2889295666 @default.
- W4377221470 cites W2889646458 @default.
- W4377221470 cites W2897723485 @default.
- W4377221470 cites W2912663500 @default.
- W4377221470 cites W2912748362 @default.
- W4377221470 cites W2920628741 @default.
- W4377221470 cites W2924354627 @default.
- W4377221470 cites W2946680409 @default.
- W4377221470 cites W2953980842 @default.
- W4377221470 cites W2964958911 @default.
- W4377221470 cites W3001796843 @default.
- W4377221470 cites W3005321840 @default.
- W4377221470 cites W3006507687 @default.
- W4377221470 cites W3007050686 @default.
- W4377221470 cites W3033762213 @default.
- W4377221470 cites W3108038580 @default.
- W4377221470 cites W3120200409 @default.
- W4377221470 cites W3192994539 @default.
- W4377221470 cites W35862036 @default.