Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377223858> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4377223858 abstract "Abstract Background The promise of immunotherapy in cancer treatment is tempered by the occurrence of immune-related adverse events (irAEs). Many patients undergoing immunotherapy also take aspirin, but the impact of aspirin on irAEs is not well understood. This study aimed to investigate the association between aspirin use and irAEs in patients receiving immunotherapy. Methods This study analyzed adverse reaction data associated with the use of immune checkpoint inhibitors (ICIs) in the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database, from the approval date of each drug until October 1, 2022. Multivariate logistic regression was employed to assess the effect of aspirin use on irAEs in patients receiving ICIs. . Results The analysis included 123,104 patients who underwent immunotherapy, of whom 5359 also received aspirin. The results showed that aspirin use was associated with an increased risk of irAEs in the pan-cancer analysis, and this association was more pronounced in specific cancer types such as lung cancer, mesothelioma, and pancreatic cancer. Additionally, aspirin use was correlated with an elevated risk of certain irAEs such as anaemia, colitis, myocarditis, myositis, pancreatitis, pericarditis and pneumonitis. Conclusions These findings suggest that aspirin exposure is associated with a higher risk of irAEs in patients undergoing cancer immunotherapy. Moreover, different cancer types and the ICI types can also impact irAEs." @default.
- W4377223858 created "2023-05-23" @default.
- W4377223858 creator A5008473414 @default.
- W4377223858 creator A5009428385 @default.
- W4377223858 creator A5011476886 @default.
- W4377223858 creator A5028990852 @default.
- W4377223858 creator A5085950812 @default.
- W4377223858 date "2023-05-22" @default.
- W4377223858 modified "2023-09-27" @default.
- W4377223858 title "Aspirin use increases risk of immune-related adverse events in cancer patients treated with immunotherapy: analysis of the FAERS database" @default.
- W4377223858 cites W2033459915 @default.
- W4377223858 cites W2102937816 @default.
- W4377223858 cites W2111175587 @default.
- W4377223858 cites W2331874851 @default.
- W4377223858 cites W2527905628 @default.
- W4377223858 cites W2529484692 @default.
- W4377223858 cites W2566809924 @default.
- W4377223858 cites W2601055810 @default.
- W4377223858 cites W2740117282 @default.
- W4377223858 cites W2786816161 @default.
- W4377223858 cites W2900174742 @default.
- W4377223858 cites W2942467666 @default.
- W4377223858 cites W2943668434 @default.
- W4377223858 cites W2953307540 @default.
- W4377223858 cites W2961982421 @default.
- W4377223858 cites W2963849817 @default.
- W4377223858 cites W2966381366 @default.
- W4377223858 cites W2966465234 @default.
- W4377223858 cites W3007710762 @default.
- W4377223858 cites W3022864888 @default.
- W4377223858 cites W3028523516 @default.
- W4377223858 cites W3092106005 @default.
- W4377223858 cites W3105880108 @default.
- W4377223858 cites W3203575974 @default.
- W4377223858 cites W3204988028 @default.
- W4377223858 cites W4205349336 @default.
- W4377223858 cites W4226360696 @default.
- W4377223858 cites W4229335924 @default.
- W4377223858 cites W4302759885 @default.
- W4377223858 cites W4312190528 @default.
- W4377223858 cites W4318200441 @default.
- W4377223858 cites W4318777408 @default.
- W4377223858 cites W4319065859 @default.
- W4377223858 doi "https://doi.org/10.21203/rs.3.rs-2934398/v1" @default.
- W4377223858 hasPublicationYear "2023" @default.
- W4377223858 type Work @default.
- W4377223858 citedByCount "0" @default.
- W4377223858 crossrefType "posted-content" @default.
- W4377223858 hasAuthorship W4377223858A5008473414 @default.
- W4377223858 hasAuthorship W4377223858A5009428385 @default.
- W4377223858 hasAuthorship W4377223858A5011476886 @default.
- W4377223858 hasAuthorship W4377223858A5028990852 @default.
- W4377223858 hasAuthorship W4377223858A5085950812 @default.
- W4377223858 hasBestOaLocation W43772238581 @default.
- W4377223858 hasConcept C121608353 @default.
- W4377223858 hasConcept C126322002 @default.
- W4377223858 hasConcept C143998085 @default.
- W4377223858 hasConcept C197934379 @default.
- W4377223858 hasConcept C2776256026 @default.
- W4377223858 hasConcept C2777628954 @default.
- W4377223858 hasConcept C2777701055 @default.
- W4377223858 hasConcept C2777714996 @default.
- W4377223858 hasConcept C2779524853 @default.
- W4377223858 hasConcept C2780030458 @default.
- W4377223858 hasConcept C71924100 @default.
- W4377223858 hasConceptScore W4377223858C121608353 @default.
- W4377223858 hasConceptScore W4377223858C126322002 @default.
- W4377223858 hasConceptScore W4377223858C143998085 @default.
- W4377223858 hasConceptScore W4377223858C197934379 @default.
- W4377223858 hasConceptScore W4377223858C2776256026 @default.
- W4377223858 hasConceptScore W4377223858C2777628954 @default.
- W4377223858 hasConceptScore W4377223858C2777701055 @default.
- W4377223858 hasConceptScore W4377223858C2777714996 @default.
- W4377223858 hasConceptScore W4377223858C2779524853 @default.
- W4377223858 hasConceptScore W4377223858C2780030458 @default.
- W4377223858 hasConceptScore W4377223858C71924100 @default.
- W4377223858 hasLocation W43772238581 @default.
- W4377223858 hasOpenAccess W4377223858 @default.
- W4377223858 hasPrimaryLocation W43772238581 @default.
- W4377223858 hasRelatedWork W2607488351 @default.
- W4377223858 hasRelatedWork W2770647538 @default.
- W4377223858 hasRelatedWork W2904759734 @default.
- W4377223858 hasRelatedWork W2972926806 @default.
- W4377223858 hasRelatedWork W3021504039 @default.
- W4377223858 hasRelatedWork W3029010559 @default.
- W4377223858 hasRelatedWork W3097428643 @default.
- W4377223858 hasRelatedWork W3215044659 @default.
- W4377223858 hasRelatedWork W4302292908 @default.
- W4377223858 hasRelatedWork W2605218106 @default.
- W4377223858 isParatext "false" @default.
- W4377223858 isRetracted "false" @default.
- W4377223858 workType "article" @default.