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- W4377226326 endingPage "286" @default.
- W4377226326 startingPage "286" @default.
- W4377226326 abstract "The management of bone defects is complicated by the presence of clinical conditions, such as critical-sized defects created by high-energy trauma, tumour resection, infection, and skeletal abnormalities, whereby the bone regeneration capacity is compromised. A bone scaffold is a three-dimensional structure matrix serving as a template to be implanted into the defects to promote vascularisation, growth factor recruitment, osteogenesis, osteoconduction, and mechanical support. This review aims to summarise the types and applications of natural and synthetic scaffolds currently adopted in bone tissue engineering. The merits and caveats of natural and synthetic scaffolds will be discussed. A naturally derived bone scaffold offers a microenvironment closer to in vivo conditions after decellularisation and demineralisation, exhibiting excellent bioactivity, biocompatibility, and osteogenic properties. Meanwhile, an artificially produced bone scaffold allows for scalability and consistency with minimal risk of disease transmission. The combination of different materials to form scaffolds, along with bone cell seeding, biochemical cue incorporation, and bioactive molecule functionalisation, can provide additional or improved scaffold properties, allowing for a faster bone repair rate in bone injuries. This is the direction for future research in the field of bone growth and repair." @default.
- W4377226326 created "2023-05-23" @default.
- W4377226326 creator A5004770379 @default.
- W4377226326 creator A5007498545 @default.
- W4377226326 creator A5022294605 @default.
- W4377226326 creator A5042383355 @default.
- W4377226326 date "2023-05-20" @default.
- W4377226326 modified "2023-10-14" @default.
- W4377226326 title "A Review of the Application of Natural and Synthetic Scaffolds in Bone Regeneration" @default.
- W4377226326 cites W1528810141 @default.
- W4377226326 cites W1923710437 @default.
- W4377226326 cites W1967181929 @default.
- W4377226326 cites W1967785392 @default.
- W4377226326 cites W1971500643 @default.
- W4377226326 cites W1973971833 @default.
- W4377226326 cites W1974193257 @default.
- W4377226326 cites W1981560476 @default.
- W4377226326 cites W1989811414 @default.
- W4377226326 cites W1991014606 @default.
- W4377226326 cites W2005688834 @default.
- W4377226326 cites W2016887295 @default.
- W4377226326 cites W2024306244 @default.
- W4377226326 cites W2024653452 @default.
- W4377226326 cites W2024785125 @default.
- W4377226326 cites W2040146194 @default.
- W4377226326 cites W2046235433 @default.
- W4377226326 cites W2052871444 @default.
- W4377226326 cites W2054263063 @default.
- W4377226326 cites W2058249306 @default.
- W4377226326 cites W2058701097 @default.
- W4377226326 cites W2060847857 @default.
- W4377226326 cites W2064290616 @default.
- W4377226326 cites W2064716145 @default.
- W4377226326 cites W2065386894 @default.
- W4377226326 cites W2066997191 @default.
- W4377226326 cites W2070399662 @default.
- W4377226326 cites W2080531849 @default.
- W4377226326 cites W2092240966 @default.
- W4377226326 cites W2099039805 @default.
- W4377226326 cites W2103947527 @default.
- W4377226326 cites W2109563809 @default.
- W4377226326 cites W2111032304 @default.
- W4377226326 cites W2115746002 @default.
- W4377226326 cites W2159185781 @default.
- W4377226326 cites W2160669265 @default.
- W4377226326 cites W2208987713 @default.
- W4377226326 cites W2285901648 @default.
- W4377226326 cites W2286432932 @default.
- W4377226326 cites W2328714619 @default.
- W4377226326 cites W2382446754 @default.
- W4377226326 cites W2394511620 @default.
- W4377226326 cites W2518196393 @default.
- W4377226326 cites W2527186678 @default.
- W4377226326 cites W2549169970 @default.
- W4377226326 cites W2578859604 @default.
- W4377226326 cites W2581540547 @default.
- W4377226326 cites W2620711380 @default.
- W4377226326 cites W2668361924 @default.
- W4377226326 cites W2739954905 @default.
- W4377226326 cites W2741789131 @default.
- W4377226326 cites W2789994485 @default.
- W4377226326 cites W2791848975 @default.
- W4377226326 cites W2793174588 @default.
- W4377226326 cites W2796120147 @default.
- W4377226326 cites W2802287640 @default.
- W4377226326 cites W2885676022 @default.
- W4377226326 cites W2891266240 @default.
- W4377226326 cites W2891366129 @default.
- W4377226326 cites W2901097670 @default.
- W4377226326 cites W2909537306 @default.
- W4377226326 cites W2910570241 @default.
- W4377226326 cites W2919078487 @default.
- W4377226326 cites W2921023186 @default.
- W4377226326 cites W2929145684 @default.
- W4377226326 cites W2945382807 @default.
- W4377226326 cites W2947664241 @default.
- W4377226326 cites W2953851434 @default.
- W4377226326 cites W2969011454 @default.
- W4377226326 cites W2979453885 @default.
- W4377226326 cites W2990958964 @default.
- W4377226326 cites W2997722139 @default.
- W4377226326 cites W3001477210 @default.
- W4377226326 cites W3004294173 @default.
- W4377226326 cites W3013843398 @default.
- W4377226326 cites W3015617343 @default.
- W4377226326 cites W3016608967 @default.
- W4377226326 cites W3026218051 @default.
- W4377226326 cites W3035905750 @default.
- W4377226326 cites W3038003753 @default.
- W4377226326 cites W3040213050 @default.
- W4377226326 cites W3043619360 @default.
- W4377226326 cites W3045513448 @default.
- W4377226326 cites W3053869388 @default.
- W4377226326 cites W3082145519 @default.
- W4377226326 cites W3090054567 @default.
- W4377226326 cites W3092429611 @default.
- W4377226326 cites W3105654555 @default.
- W4377226326 cites W3112947208 @default.