Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377227186> ?p ?o ?g. }
- W4377227186 endingPage "915" @default.
- W4377227186 startingPage "905" @default.
- W4377227186 abstract "The dorsal lateral prefrontal cortex (DLPFC) has been identified as a neuromodulation target for alleviating suicidal ideation. Dysfunctional DLPFC has been implicated in suicidality in depression. This study aimed to investigate the functional connectivity (FC) of the DLPFC in late-life depression (LLD) with suicidal ideation.Resting-state functional magnetic resonance imaging (fMRI) data from 32 LLD patients with suicidal ideation (LLD-S), 41 LLD patients without suicidal ideation (LLD-NS), and 54 healthy older adults (HOA) were analyzed using DLPFC seed-based FC analyses. Group differences in FC were examined, and machine learning was applied to explore the potential of DLPFC-FC for classifying LLD-S from LLD-NS.Abnormal DLPFC-FC patterns were observed in LLD-S, characterized by lower connectivity with the angular gyrus, precuneus, and superior frontal gyrus compared to LLD-NS and healthy controls. A classification model based on the identified DLPFC-FC achieved an accuracy of 75%.The lower FC of DLPFC networks may contribute to the neurobiological mechanism of suicidal ideation in late-life depression. These findings may facilitate suicide prevention for LLD by providing potential neuroimaging markers and network-based neuromodulation targets. However, further confirmation with larger sample sizes and experimental designs is warranted." @default.
- W4377227186 created "2023-05-23" @default.
- W4377227186 creator A5017366700 @default.
- W4377227186 creator A5025285333 @default.
- W4377227186 creator A5030863883 @default.
- W4377227186 creator A5033222197 @default.
- W4377227186 creator A5036459279 @default.
- W4377227186 creator A5053204257 @default.
- W4377227186 creator A5065162774 @default.
- W4377227186 creator A5074189384 @default.
- W4377227186 creator A5080646236 @default.
- W4377227186 creator A5080996580 @default.
- W4377227186 creator A5089004185 @default.
- W4377227186 creator A5090819536 @default.
- W4377227186 date "2023-11-01" @default.
- W4377227186 modified "2023-10-13" @default.
- W4377227186 title "Lower Dorsal Lateral Prefrontal Cortex Functional Connectivity in Late-Life Depression With Suicidal Ideation" @default.
- W4377227186 cites W1552179169 @default.
- W4377227186 cites W1966226738 @default.
- W4377227186 cites W2000915215 @default.
- W4377227186 cites W2005238835 @default.
- W4377227186 cites W2017407197 @default.
- W4377227186 cites W2020259042 @default.
- W4377227186 cites W2025265762 @default.
- W4377227186 cites W2027584553 @default.
- W4377227186 cites W2027913645 @default.
- W4377227186 cites W2044984028 @default.
- W4377227186 cites W2058467798 @default.
- W4377227186 cites W2074925324 @default.
- W4377227186 cites W2082829063 @default.
- W4377227186 cites W2085606083 @default.
- W4377227186 cites W2087626677 @default.
- W4377227186 cites W2091687415 @default.
- W4377227186 cites W2107693566 @default.
- W4377227186 cites W2121014019 @default.
- W4377227186 cites W2136435696 @default.
- W4377227186 cites W2139505744 @default.
- W4377227186 cites W2146083743 @default.
- W4377227186 cites W2151591509 @default.
- W4377227186 cites W2156102898 @default.
- W4377227186 cites W2158327608 @default.
- W4377227186 cites W2172023369 @default.
- W4377227186 cites W2279240032 @default.
- W4377227186 cites W2318787377 @default.
- W4377227186 cites W2337323496 @default.
- W4377227186 cites W247871665 @default.
- W4377227186 cites W2551577835 @default.
- W4377227186 cites W2573819071 @default.
- W4377227186 cites W2590906340 @default.
- W4377227186 cites W2750946741 @default.
- W4377227186 cites W2758974767 @default.
- W4377227186 cites W2768475644 @default.
- W4377227186 cites W2773963112 @default.
- W4377227186 cites W2800752517 @default.
- W4377227186 cites W2803650243 @default.
- W4377227186 cites W2895857000 @default.
- W4377227186 cites W2899271656 @default.
- W4377227186 cites W2900552088 @default.
- W4377227186 cites W2927777239 @default.
- W4377227186 cites W2964643970 @default.
- W4377227186 cites W2979769017 @default.
- W4377227186 cites W2990590397 @default.
- W4377227186 cites W3035127016 @default.
- W4377227186 cites W3105741539 @default.
- W4377227186 cites W3125553198 @default.
- W4377227186 cites W3137301420 @default.
- W4377227186 cites W3160396946 @default.
- W4377227186 cites W3179305587 @default.
- W4377227186 cites W3182325079 @default.
- W4377227186 cites W3189676709 @default.
- W4377227186 cites W3195973239 @default.
- W4377227186 cites W3197090776 @default.
- W4377227186 cites W4200552467 @default.
- W4377227186 cites W4205544279 @default.
- W4377227186 cites W4213417514 @default.
- W4377227186 cites W4307455495 @default.
- W4377227186 cites W4780062 @default.
- W4377227186 doi "https://doi.org/10.1016/j.jagp.2023.05.006" @default.
- W4377227186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37271652" @default.
- W4377227186 hasPublicationYear "2023" @default.
- W4377227186 type Work @default.
- W4377227186 citedByCount "1" @default.
- W4377227186 countsByYear W43772271862023 @default.
- W4377227186 crossrefType "journal-article" @default.
- W4377227186 hasAuthorship W4377227186A5017366700 @default.
- W4377227186 hasAuthorship W4377227186A5025285333 @default.
- W4377227186 hasAuthorship W4377227186A5030863883 @default.
- W4377227186 hasAuthorship W4377227186A5033222197 @default.
- W4377227186 hasAuthorship W4377227186A5036459279 @default.
- W4377227186 hasAuthorship W4377227186A5053204257 @default.
- W4377227186 hasAuthorship W4377227186A5065162774 @default.
- W4377227186 hasAuthorship W4377227186A5074189384 @default.
- W4377227186 hasAuthorship W4377227186A5080646236 @default.
- W4377227186 hasAuthorship W4377227186A5080996580 @default.
- W4377227186 hasAuthorship W4377227186A5089004185 @default.
- W4377227186 hasAuthorship W4377227186A5090819536 @default.
- W4377227186 hasConcept C15744967 @default.
- W4377227186 hasConcept C169760540 @default.