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- W4377233003 abstract "Abstract There is an urgent need to develop new tumor biomarkers for early cancer detection, but the variability of tumor-derived antigens has been a limitation. Here we demonstrate a novel anti-Tn antibody microarray platform to detect Tn+ glycoproteins, a near universal antigen in carcinoma-derived glycoproteins, for broad detection of cancer. The platform uses a specific recombinant IgG1 to the Tn antigen (CD175) as a capture reagent and a recombinant IgM to the Tn antigen as a detecting reagent. These reagents were validated by immunohistochemistry in recognizing the Tn antigen using hundreds of human tumor specimens. Using this approach, we could detect Tn+ glycoproteins at subnanogram levels using cell lines and culture media, serum, and stool samples from mice engineered to express the Tn antigen in intestinal epithelial cells. The development of a general cancer detection platform using recombinant antibodies for detection of altered tumor glycoproteins expressing a unique antigen could have a significant impact on cancer detection and monitoring." @default.
- W4377233003 created "2023-05-23" @default.
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- W4377233003 date "2023-05-22" @default.
- W4377233003 modified "2023-10-17" @default.
- W4377233003 title "Targeting altered glycosylation in secreted tumor glycoproteins for broad cancer detection" @default.
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- W4377233003 doi "https://doi.org/10.1093/glycob/cwad035" @default.
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