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• W4377263944 endingPage "215228" @default.
• W4377263944 startingPage "215228" @default.
• W4377263944 abstract "Sulfonamides revolutionized the treatment and management of bacterial infections. Prontosil was the very first synthetic antibacterial agent ever used in the clinics and its metabolite, sulfanilamide, led to the development of a diverse range of sulfonamides with a diverse spectrum of action. Although being developed as antibacterial agents, sulfonamides have also shown to present antitumor, antifungal, and antiviral activities. While for antibacterial applications the focus is on the dihydropteroate synthase enzyme, for antitumor compounds a lot of attention has been given to carbonic anhydrases. For antiviral applications some studies focus on inhibiting HIV replication, and with the COVID-19 pandemic in the last years, attention has been given to inhibit SARS-CoV-2 replication as well. For antifungal applications it seems there is a lack of target focus, but with some compounds presenting relevant activities. Silver sulfadiazine was the first metal complex of a sulfonamide to be used in the clinics as a topical agent for prevention and treatment of infections in burn patients and is vastly used to this day. Here, we covered the history of silver sulfadiazine development, its chemical properties, antibacterial activity and clinical data. Controversial results on the true efficacy of silver sulfadiazine as a topical treatment for burn wounds gave rise to ongoing debate on the advantages of using this compound when compared to other dressings loaded or not with silver-containing agents. Nonetheless, the 50-year history of silver sulfadiazine’s successful use in the clinics has motivated the development of other metal complexes of sulfonamides, which are reviewed here. The biological endpoints for these novel metal complexes were not limited to antibacterial use, but expanded to antitumor, antifungal, and antiviral applications as well. Altogether, this review presents the developments in the applications of metal complexes of sulfonamides in medicinal inorganic chemistry in the past years." @default.
• W4377263944 created "2023-05-23" @default.
• W4377263944 creator A5060680588 @default.
• W4377263944 creator A5065464354 @default.
• W4377263944 creator A5071615572 @default.
• W4377263944 creator A5074108720 @default.
• W4377263944 date "2023-09-01" @default.
• W4377263944 modified "2023-10-05" @default.
• W4377263944 title "Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry" @default.
• W4377263944 cites W101691944 @default.
• W4377263944 cites W1503991759 @default.
• W4377263944 cites W1557990487 @default.
• W4377263944 cites W1602205871 @default.
• W4377263944 cites W1765119761 @default.
• W4377263944 cites W1862523109 @default.
• W4377263944 cites W1947292443 @default.
• W4377263944 cites W1964147308 @default.
• W4377263944 cites W1964719327 @default.
• W4377263944 cites W1965998946 @default.
• W4377263944 cites W1966450518 @default.
• W4377263944 cites W1969245878 @default.
• W4377263944 cites W1971132520 @default.
• W4377263944 cites W1972315532 @default.
• W4377263944 cites W1972547175 @default.
• W4377263944 cites W1976538675 @default.
• W4377263944 cites W1978820461 @default.
• W4377263944 cites W1979035316 @default.
• W4377263944 cites W1980368583 @default.
• W4377263944 cites W1983717458 @default.
• W4377263944 cites W1986258488 @default.
• W4377263944 cites W1986373220 @default.
• W4377263944 cites W1987158405 @default.
• W4377263944 cites W1988987714 @default.
• W4377263944 cites W1990331048 @default.
• W4377263944 cites W1990659273 @default.
• W4377263944 cites W1990725152 @default.
• W4377263944 cites W1992312870 @default.
• W4377263944 cites W1996282208 @default.
• W4377263944 cites W2003070710 @default.
• W4377263944 cites W2004905031 @default.
• W4377263944 cites W2004962624 @default.
• W4377263944 cites W2005368161 @default.
• W4377263944 cites W2006470809 @default.
• W4377263944 cites W2007205390 @default.
• W4377263944 cites W2007695861 @default.
• W4377263944 cites W2009514704 @default.
• W4377263944 cites W2011851567 @default.
• W4377263944 cites W2011906070 @default.
• W4377263944 cites W2015838724 @default.
• W4377263944 cites W2017688478 @default.
• W4377263944 cites W2018512578 @default.
• W4377263944 cites W2019077565 @default.
• W4377263944 cites W2019602861 @default.
• W4377263944 cites W2020932235 @default.
• W4377263944 cites W2021910827 @default.
• W4377263944 cites W2023174370 @default.
• W4377263944 cites W2030623460 @default.
• W4377263944 cites W2033256250 @default.
• W4377263944 cites W2038493984 @default.
• W4377263944 cites W2043356185 @default.
• W4377263944 cites W2044107067 @default.
• W4377263944 cites W2047178318 @default.
• W4377263944 cites W2047960647 @default.
• W4377263944 cites W2048253776 @default.
• W4377263944 cites W2050144326 @default.
• W4377263944 cites W2054209009 @default.
• W4377263944 cites W2054673591 @default.
• W4377263944 cites W2054929462 @default.
• W4377263944 cites W2055547673 @default.
• W4377263944 cites W2057771684 @default.
• W4377263944 cites W2059629279 @default.
• W4377263944 cites W2060525822 @default.
• W4377263944 cites W2060825987 @default.
• W4377263944 cites W2060927874 @default.
• W4377263944 cites W2061151325 @default.
• W4377263944 cites W2061651826 @default.
• W4377263944 cites W2068925567 @default.
• W4377263944 cites W2071934429 @default.
• W4377263944 cites W2073647415 @default.
• W4377263944 cites W2074837244 @default.
• W4377263944 cites W2075033528 @default.
• W4377263944 cites W2075283286 @default.
• W4377263944 cites W2082520563 @default.
• W4377263944 cites W2083787732 @default.
• W4377263944 cites W2087042581 @default.
• W4377263944 cites W2094083551 @default.
• W4377263944 cites W2101680235 @default.
• W4377263944 cites W2102342403 @default.
• W4377263944 cites W2106352535 @default.
• W4377263944 cites W2116184358 @default.
• W4377263944 cites W2117692326 @default.
• W4377263944 cites W2131508727 @default.
• W4377263944 cites W2132083467 @default.
• W4377263944 cites W2133791017 @default.
• W4377263944 cites W2138298207 @default.
• W4377263944 cites W2138587373 @default.
• W4377263944 cites W2146761742 @default.
• W4377263944 cites W2149487748 @default.

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