Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377287053> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4377287053 abstract "Abstract Introduction Collagenase clostridium histolyticum (CCH) is the only food and drug administration (FDA) approved intralesional medication for Peyronies Disease (PD). The manufacture instructions recommend a single injection into the plaque at the point of maximal curvature. However, a 2019 survey of the Sexual Medicine Society of North America (SMSNA) found that physicians were utilizing many different injection techniques. It is unknown if one technique is superior. Objective To assess delivery of medication into PD plaques using an invitro model. Methods We obtained PD plaques from men undergoing plaque excision and grafting. Plaques were stored at -80C until ready for use in the lab. We injected the plaques with 0.25ml of Eosin Y, 5 wt. 5% solution in water because this solution is visibly red and similar to the density of CCH. We assess how the dye spread through the plaque in four different injection techniques: single injection, single injection with slow pull back, multiple site injection and lateral injection. All injections were video recorded in real time. Results Dye was retained inside the plaques will all injection techniques, however in all conditions, a significant amount of dye leaked out of the plaques. Multiple injection technique appeared to have the least about of dye leak out of the plaque. Conclusions In all conditions, dye leaked out of the plaques, however the multiple injection technique appears to have deliver the greatest amount Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: Endo Pharmaceuticals" @default.
- W4377287053 created "2023-05-23" @default.
- W4377287053 creator A5040407178 @default.
- W4377287053 creator A5045254927 @default.
- W4377287053 creator A5048136956 @default.
- W4377287053 creator A5091996967 @default.
- W4377287053 date "2023-05-01" @default.
- W4377287053 modified "2023-10-16" @default.
- W4377287053 title "(402) Analysis of Peyronie’s Disease Injection Techniques" @default.
- W4377287053 doi "https://doi.org/10.1093/jsxmed/qdad060.376" @default.
- W4377287053 hasPublicationYear "2023" @default.
- W4377287053 type Work @default.
- W4377287053 citedByCount "0" @default.
- W4377287053 crossrefType "journal-article" @default.
- W4377287053 hasAuthorship W4377287053A5040407178 @default.
- W4377287053 hasAuthorship W4377287053A5045254927 @default.
- W4377287053 hasAuthorship W4377287053A5048136956 @default.
- W4377287053 hasAuthorship W4377287053A5091996967 @default.
- W4377287053 hasConcept C141071460 @default.
- W4377287053 hasConcept C181199279 @default.
- W4377287053 hasConcept C185592680 @default.
- W4377287053 hasConcept C2778394429 @default.
- W4377287053 hasConcept C3018890749 @default.
- W4377287053 hasConcept C55493867 @default.
- W4377287053 hasConcept C71924100 @default.
- W4377287053 hasConcept C98274493 @default.
- W4377287053 hasConceptScore W4377287053C141071460 @default.
- W4377287053 hasConceptScore W4377287053C181199279 @default.
- W4377287053 hasConceptScore W4377287053C185592680 @default.
- W4377287053 hasConceptScore W4377287053C2778394429 @default.
- W4377287053 hasConceptScore W4377287053C3018890749 @default.
- W4377287053 hasConceptScore W4377287053C55493867 @default.
- W4377287053 hasConceptScore W4377287053C71924100 @default.
- W4377287053 hasConceptScore W4377287053C98274493 @default.
- W4377287053 hasIssue "Supplement_1" @default.
- W4377287053 hasLocation W43772870531 @default.
- W4377287053 hasOpenAccess W4377287053 @default.
- W4377287053 hasPrimaryLocation W43772870531 @default.
- W4377287053 hasRelatedWork W2002120878 @default.
- W4377287053 hasRelatedWork W2003938723 @default.
- W4377287053 hasRelatedWork W2047967234 @default.
- W4377287053 hasRelatedWork W2118496982 @default.
- W4377287053 hasRelatedWork W2364998975 @default.
- W4377287053 hasRelatedWork W2369162477 @default.
- W4377287053 hasRelatedWork W2439875401 @default.
- W4377287053 hasRelatedWork W4238867864 @default.
- W4377287053 hasRelatedWork W2519357708 @default.
- W4377287053 hasRelatedWork W2525756941 @default.
- W4377287053 hasVolume "20" @default.
- W4377287053 isParatext "false" @default.
- W4377287053 isRetracted "false" @default.
- W4377287053 workType "article" @default.