FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377287508> ?p ?o ?g. }

• W4377287508 abstract "Introduction: Acute respiratory distress syndrome (ARDS) remains a major clinical challenge for patients in intensive care units. Determining the differential mechanisms underlying ARDS with different etiologies is a key goal to improve the effectiveness of ARDS therapy. Despite growing evidence that different immune cell types are involved in ARDS, the role of altered immune cell subpopulations in disease progression is unelucidated. Methods: In this study, we combined scRNA-seq and bulk-level sequencing to analyze the transcriptomes of peripheral blood mononuclear cells from healthy volunteers and patients with septic ARDS (sep-ARDS) and pneumonic ARDS (PNE-ARDS). Results: Our data revealed differential alterations at the cellular and molecular levels and within biological signaling pathways in ARDS with different etiologies. The dynamics of neutrophils, macrophages (Macs), classical dendritic cells (cDCs), myeloid-derived suppressive cells (MDSCs), and CD8 + T cells varied significantly among groups of different samples, with neutrophils and cDCs at higher, and Macs at significantly lower, amounts in the patients with sep-ARDS. Furthermore, MDSCs were highly enriched only in the sep-ARDS patients, whereas a higher abundance of CD8 + T cells was observed in patients with PNE-ARDS. In addition, these cell subpopulations were found to be significantly involved in apoptosis, inflammatory, and immune-related pathways. In particular, a significant enhancement of the oxidative stress response was observed in the neutrophil subpopulation. Conclusion: Our study shows that the composition of cells involved in the main peripheral circulation differs in patients with ARDS with different etiologies. Studying the role and mechanism of action of these cells during ARDS will provide new opportunities for the treatment of this condition." @default.
• W4377287508 created "2023-05-23" @default.
• W4377287508 creator A5009181056 @default.
• W4377287508 creator A5018841167 @default.
• W4377287508 creator A5025925916 @default.
• W4377287508 creator A5029653463 @default.
• W4377287508 creator A5036215524 @default.
• W4377287508 creator A5056009333 @default.
• W4377287508 creator A5058205856 @default.
• W4377287508 creator A5063201027 @default.
• W4377287508 creator A5077373961 @default.
• W4377287508 creator A5084438133 @default.
• W4377287508 date "2023-05-22" @default.
• W4377287508 modified "2023-10-01" @default.
• W4377287508 title "Single-cell analysis reveals dysregulated inflammatory response in peripheral blood immunity in patients with acute respiratory distress syndrome" @default.
• W4377287508 cites W1964453580 @default.
• W4377287508 cites W1984883254 @default.
• W4377287508 cites W1995084858 @default.
• W4377287508 cites W2019131650 @default.
• W4377287508 cites W2035618305 @default.
• W4377287508 cites W2057453699 @default.
• W4377287508 cites W2092075198 @default.
• W4377287508 cites W2102278945 @default.
• W4377287508 cites W2106923828 @default.
• W4377287508 cites W2136506501 @default.
• W4377287508 cites W2136986551 @default.
• W4377287508 cites W2146512944 @default.
• W4377287508 cites W2172055821 @default.
• W4377287508 cites W2266683146 @default.
• W4377287508 cites W2286228001 @default.
• W4377287508 cites W2291831581 @default.
• W4377287508 cites W2327403217 @default.
• W4377287508 cites W2462013578 @default.
• W4377287508 cites W2556393896 @default.
• W4377287508 cites W2597070792 @default.
• W4377287508 cites W2752984482 @default.
• W4377287508 cites W2768029258 @default.
• W4377287508 cites W2772416957 @default.
• W4377287508 cites W2793513555 @default.
• W4377287508 cites W2794480084 @default.
• W4377287508 cites W2801830373 @default.
• W4377287508 cites W2802595885 @default.
• W4377287508 cites W2807208465 @default.
• W4377287508 cites W2807906301 @default.
• W4377287508 cites W2884946210 @default.
• W4377287508 cites W2901824420 @default.
• W4377287508 cites W2902652978 @default.
• W4377287508 cites W2915104822 @default.
• W4377287508 cites W2945777288 @default.
• W4377287508 cites W2949177718 @default.
• W4377287508 cites W2973228172 @default.
• W4377287508 cites W2973677178 @default.
• W4377287508 cites W2976456440 @default.
• W4377287508 cites W2977270190 @default.
• W4377287508 cites W3003212076 @default.
• W4377287508 cites W3008028633 @default.
• W4377287508 cites W3012735630 @default.
• W4377287508 cites W3017056623 @default.
• W4377287508 cites W3036206386 @default.
• W4377287508 cites W3036760806 @default.
• W4377287508 cites W3041595964 @default.
• W4377287508 cites W3045875966 @default.
• W4377287508 cites W3094833255 @default.
• W4377287508 cites W3112188683 @default.
• W4377287508 cites W3123531243 @default.
• W4377287508 cites W3157291485 @default.
• W4377287508 cites W3157951048 @default.
• W4377287508 cites W3165656738 @default.
• W4377287508 cites W3165907912 @default.
• W4377287508 cites W4205735962 @default.
• W4377287508 cites W4211250103 @default.
• W4377287508 cites W4213245349 @default.
• W4377287508 doi "https://doi.org/10.3389/fcell.2023.1199122" @default.
• W4377287508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37283946" @default.
• W4377287508 hasPublicationYear "2023" @default.
• W4377287508 type Work @default.
• W4377287508 citedByCount "1" @default.
• W4377287508 countsByYear W43772875082023 @default.
• W4377287508 crossrefType "journal-article" @default.
• W4377287508 hasAuthorship W4377287508A5009181056 @default.
• W4377287508 hasAuthorship W4377287508A5018841167 @default.
• W4377287508 hasAuthorship W4377287508A5025925916 @default.
• W4377287508 hasAuthorship W4377287508A5029653463 @default.
• W4377287508 hasAuthorship W4377287508A5036215524 @default.
• W4377287508 hasAuthorship W4377287508A5056009333 @default.
• W4377287508 hasAuthorship W4377287508A5058205856 @default.
• W4377287508 hasAuthorship W4377287508A5063201027 @default.
• W4377287508 hasAuthorship W4377287508A5077373961 @default.
• W4377287508 hasAuthorship W4377287508A5084438133 @default.
• W4377287508 hasBestOaLocation W43772875081 @default.
• W4377287508 hasConcept C126322002 @default.
• W4377287508 hasConcept C137061746 @default.
• W4377287508 hasConcept C167672396 @default.
• W4377287508 hasConcept C202751555 @default.
• W4377287508 hasConcept C203014093 @default.
• W4377287508 hasConcept C2776348555 @default.
• W4377287508 hasConcept C2776914184 @default.
• W4377287508 hasConcept C2777714996 @default.
• W4377287508 hasConcept C2781184567 @default.
• W4377287508 hasConcept C55493867 @default.

• next