FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377287718> ?p ?o ?g. }

• W4377287718 abstract "The sense of taste starts with activation of receptor cells in taste buds by chemical stimuli which then communicate this signal via innervating oral sensory neurons to the CNS. The cell bodies of oral sensory neurons reside in the geniculate ganglion (GG) and nodose/petrosal/jugular ganglion. The geniculate ganglion contains two main neuronal populations: BRN3A+ somatosensory neurons that innervate the pinna and PHOX2B+ sensory neurons that innervate the oral cavity. While much is known about the different taste bud cell subtypes, considerably less is known about the molecular identities of PHOX2B+ sensory subpopulations. In the GG, as many as 12 different subpopulations have been predicted from electrophysiological studies, while transcriptional identities exist for only 3 to 6. Importantly, the cell fate pathways that diversify PHOX2B+ oral sensory neurons into these subpopulations are unknown. The transcription factor EGR4 was identified as being highly expressed in GG neurons. EGR4 deletion causes GG oral sensory neurons to lose their expression of PHOX2B and other oral sensory genes and up-regulate BRN3A. This is followed by a loss of chemosensory innervation of taste buds, a loss of type II taste cells responsive to bitter, sweet, and umami stimuli, and a concomitant increase in type I glial-like taste bud cells. These deficits culminate in a loss of nerve responses to sweet and umami taste qualities. Taken together, we identify a critical role of EGR4 in cell fate specification and maintenance of subpopulations of GG neurons, which in turn maintain the appropriate sweet and umami taste receptor cells." @default.
• W4377287718 created "2023-05-23" @default.
• W4377287718 creator A5012900244 @default.
• W4377287718 creator A5022358005 @default.
• W4377287718 creator A5025543503 @default.
• W4377287718 creator A5031275786 @default.
• W4377287718 creator A5067710731 @default.
• W4377287718 creator A5076785173 @default.
• W4377287718 date "2023-05-22" @default.
• W4377287718 modified "2023-09-23" @default.
• W4377287718 title "EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste" @default.
• W4377287718 cites W1174817139 @default.
• W4377287718 cites W1541874566 @default.
• W4377287718 cites W1968988955 @default.
• W4377287718 cites W1970245599 @default.
• W4377287718 cites W1971401852 @default.
• W4377287718 cites W1971833595 @default.
• W4377287718 cites W1979281691 @default.
• W4377287718 cites W1985531849 @default.
• W4377287718 cites W1987014667 @default.
• W4377287718 cites W2013024159 @default.
• W4377287718 cites W2013411637 @default.
• W4377287718 cites W2014488464 @default.
• W4377287718 cites W2021110224 @default.
• W4377287718 cites W2029966635 @default.
• W4377287718 cites W2030085291 @default.
• W4377287718 cites W2036192441 @default.
• W4377287718 cites W2041965404 @default.
• W4377287718 cites W2051588335 @default.
• W4377287718 cites W2064217286 @default.
• W4377287718 cites W2064983289 @default.
• W4377287718 cites W2081947473 @default.
• W4377287718 cites W2090058363 @default.
• W4377287718 cites W2091760668 @default.
• W4377287718 cites W2092925239 @default.
• W4377287718 cites W2098533907 @default.
• W4377287718 cites W2098565860 @default.
• W4377287718 cites W2100606566 @default.
• W4377287718 cites W2103017472 @default.
• W4377287718 cites W2104457664 @default.
• W4377287718 cites W2112064082 @default.
• W4377287718 cites W2114104545 @default.
• W4377287718 cites W2118548518 @default.
• W4377287718 cites W2130116522 @default.
• W4377287718 cites W2135511968 @default.
• W4377287718 cites W2146152985 @default.
• W4377287718 cites W2150577505 @default.
• W4377287718 cites W2167279371 @default.
• W4377287718 cites W2169456326 @default.
• W4377287718 cites W2220438441 @default.
• W4377287718 cites W2543854875 @default.
• W4377287718 cites W2557574279 @default.
• W4377287718 cites W2622290652 @default.
• W4377287718 cites W2695848533 @default.
• W4377287718 cites W2742044309 @default.
• W4377287718 cites W2742748694 @default.
• W4377287718 cites W2758667792 @default.
• W4377287718 cites W2759267903 @default.
• W4377287718 cites W2770191052 @default.
• W4377287718 cites W2775967759 @default.
• W4377287718 cites W2777670707 @default.
• W4377287718 cites W2783870236 @default.
• W4377287718 cites W2921662595 @default.
• W4377287718 cites W2973570598 @default.
• W4377287718 cites W3049514575 @default.
• W4377287718 cites W3112600195 @default.
• W4377287718 cites W3113403393 @default.
• W4377287718 cites W3127663872 @default.
• W4377287718 cites W3128652580 @default.
• W4377287718 cites W3167695230 @default.
• W4377287718 cites W3202416243 @default.
• W4377287718 cites W4377287718 @default.
• W4377287718 doi "https://doi.org/10.1073/pnas.2217595120" @default.
• W4377287718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37216536" @default.
• W4377287718 hasPublicationYear "2023" @default.
• W4377287718 type Work @default.
• W4377287718 citedByCount "1" @default.
• W4377287718 countsByYear W43772877182023 @default.
• W4377287718 crossrefType "journal-article" @default.
• W4377287718 hasAuthorship W4377287718A5012900244 @default.
• W4377287718 hasAuthorship W4377287718A5022358005 @default.
• W4377287718 hasAuthorship W4377287718A5025543503 @default.
• W4377287718 hasAuthorship W4377287718A5031275786 @default.
• W4377287718 hasAuthorship W4377287718A5067710731 @default.
• W4377287718 hasAuthorship W4377287718A5076785173 @default.
• W4377287718 hasBestOaLocation W43772877181 @default.
• W4377287718 hasConcept C142724271 @default.
• W4377287718 hasConcept C169760540 @default.
• W4377287718 hasConcept C172497186 @default.
• W4377287718 hasConcept C178006227 @default.
• W4377287718 hasConcept C204787440 @default.
• W4377287718 hasConcept C24998067 @default.
• W4377287718 hasConcept C2775908076 @default.
• W4377287718 hasConcept C2776946002 @default.
• W4377287718 hasConcept C2777687625 @default.
• W4377287718 hasConcept C2778097013 @default.
• W4377287718 hasConcept C2780833121 @default.
• W4377287718 hasConcept C2781334511 @default.
• W4377287718 hasConcept C2781404750 @default.
• W4377287718 hasConcept C2909127448 @default.

• next