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- W4377291562 endingPage "869" @default.
- W4377291562 startingPage "869" @default.
- W4377291562 abstract "The regulation of mitochondria structure and function is at the core of numerous viral infections. Acting in support of the host or of virus replication, mitochondria regulation facilitates control of energy metabolism, apoptosis, and immune signaling. Accumulating studies have pointed to post-translational modification (PTM) of mitochondrial proteins as a critical component of such regulatory mechanisms. Mitochondrial PTMs have been implicated in the pathology of several diseases and emerging evidence is starting to highlight essential roles in the context of viral infections. Here, we provide an overview of the growing arsenal of PTMs decorating mitochondrial proteins and their possible contribution to the infection-induced modulation of bioenergetics, apoptosis, and immune responses. We further consider links between PTM changes and mitochondrial structure remodeling, as well as the enzymatic and non-enzymatic mechanisms underlying mitochondrial PTM regulation. Finally, we highlight some of the methods, including mass spectrometry-based analyses, available for the identification, prioritization, and mechanistic interrogation of PTMs." @default.
- W4377291562 created "2023-05-23" @default.
- W4377291562 creator A5013237837 @default.
- W4377291562 creator A5016184844 @default.
- W4377291562 creator A5047437797 @default.
- W4377291562 date "2023-05-20" @default.
- W4377291562 modified "2023-09-28" @default.
- W4377291562 title "Orchestration of Mitochondrial Function and Remodeling by Post-Translational Modifications Provide Insight into Mechanisms of Viral Infection" @default.
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