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- W4377292543 abstract "Abstract Skeletal muscle regeneration involves coordinated interactions between different cell types. Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but whether platelets promote regeneration beyond their role in hemostasis remains unexplored. Here, we find that signaling via platelet-released chemokines is an early event necessary for muscle repair in mice. Platelet depletion reduces the levels of the platelet-secreted neutrophil chemoattractants CXCL5 and CXCL7/PPBP. Consequently, early-phase neutrophil infiltration to injured muscles is impaired whereas later inflammation is exacerbated. Consistent with this model, neutrophil infiltration to injured muscles is compromised in male mice with Cxcl7-knockout platelets. Moreover, neo-angiogenesis and the re-establishment of myofiber size and muscle strength occurs optimally in control mice post-injury but not in Cxcl7ko mice and in neutrophil-depleted mice. Altogether, these findings indicate that platelet-secreted CXCL7 promotes regeneration by recruiting neutrophils to injured muscles, and that this signaling axis could be utilized therapeutically to boost muscle regeneration." @default.
- W4377292543 created "2023-05-23" @default.
- W4377292543 creator A5032411137 @default.
- W4377292543 creator A5034565792 @default.
- W4377292543 creator A5035786541 @default.
- W4377292543 creator A5046984456 @default.
- W4377292543 creator A5078070376 @default.
- W4377292543 creator A5088793975 @default.
- W4377292543 creator A5062052747 @default.
- W4377292543 date "2023-05-22" @default.
- W4377292543 modified "2023-09-30" @default.
- W4377292543 title "Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles" @default.
- W4377292543 cites W1142031920 @default.
- W4377292543 cites W1534052749 @default.
- W4377292543 cites W1539373078 @default.
- W4377292543 cites W1541138918 @default.
- W4377292543 cites W1573544812 @default.
- W4377292543 cites W1600560134 @default.
- W4377292543 cites W1604404839 @default.
- W4377292543 cites W1707922975 @default.
- W4377292543 cites W1886185926 @default.
- W4377292543 cites W1975031413 @default.
- W4377292543 cites W1975574418 @default.
- W4377292543 cites W1979533069 @default.
- W4377292543 cites W1985853491 @default.
- W4377292543 cites W1988212011 @default.
- W4377292543 cites W1990770540 @default.
- W4377292543 cites W1996765015 @default.
- W4377292543 cites W1998118119 @default.
- W4377292543 cites W2005111614 @default.
- W4377292543 cites W2007486557 @default.
- W4377292543 cites W2017429680 @default.
- W4377292543 cites W2019791508 @default.
- W4377292543 cites W2021065306 @default.
- W4377292543 cites W2026240949 @default.
- W4377292543 cites W2030190455 @default.
- W4377292543 cites W2032600755 @default.
- W4377292543 cites W2044640065 @default.
- W4377292543 cites W2053867901 @default.
- W4377292543 cites W2054834672 @default.
- W4377292543 cites W2056672437 @default.
- W4377292543 cites W2057242413 @default.
- W4377292543 cites W2058217708 @default.
- W4377292543 cites W2059423359 @default.
- W4377292543 cites W2061353791 @default.
- W4377292543 cites W2062520524 @default.
- W4377292543 cites W2063881294 @default.
- W4377292543 cites W2073520086 @default.
- W4377292543 cites W2076615553 @default.
- W4377292543 cites W2080485793 @default.
- W4377292543 cites W2091854627 @default.
- W4377292543 cites W2103398208 @default.
- W4377292543 cites W2103706790 @default.
- W4377292543 cites W2108723188 @default.
- W4377292543 cites W2114056096 @default.
- W4377292543 cites W2117985944 @default.
- W4377292543 cites W2124422993 @default.
- W4377292543 cites W2125045325 @default.
- W4377292543 cites W2127920599 @default.
- W4377292543 cites W2132099989 @default.
- W4377292543 cites W2132739672 @default.
- W4377292543 cites W2134094618 @default.
- W4377292543 cites W2136735792 @default.
- W4377292543 cites W2142461098 @default.
- W4377292543 cites W2152140971 @default.
- W4377292543 cites W2153364645 @default.
- W4377292543 cites W2154964493 @default.
- W4377292543 cites W2155490506 @default.
- W4377292543 cites W2157364879 @default.
- W4377292543 cites W2166059867 @default.
- W4377292543 cites W2170164215 @default.
- W4377292543 cites W2170313716 @default.
- W4377292543 cites W2179125235 @default.
- W4377292543 cites W2181268165 @default.
- W4377292543 cites W2193057007 @default.
- W4377292543 cites W2267893954 @default.
- W4377292543 cites W2271088568 @default.
- W4377292543 cites W2274703182 @default.
- W4377292543 cites W2280244638 @default.
- W4377292543 cites W228529876 @default.
- W4377292543 cites W2288900429 @default.
- W4377292543 cites W2301044272 @default.
- W4377292543 cites W2329665596 @default.
- W4377292543 cites W2407991402 @default.
- W4377292543 cites W2472160873 @default.
- W4377292543 cites W2490643024 @default.
- W4377292543 cites W252852947 @default.
- W4377292543 cites W2529754782 @default.
- W4377292543 cites W2552333311 @default.
- W4377292543 cites W2562503458 @default.
- W4377292543 cites W2565805996 @default.
- W4377292543 cites W2587398364 @default.
- W4377292543 cites W2589121907 @default.
- W4377292543 cites W2589386457 @default.
- W4377292543 cites W2615170291 @default.
- W4377292543 cites W2621934018 @default.
- W4377292543 cites W2735513135 @default.
- W4377292543 cites W2748712297 @default.
- W4377292543 cites W2773549048 @default.
- W4377292543 cites W2789205673 @default.