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• W4377293234 abstract "Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) reveals chromatin accessibility across the genome. Currently, no method specifically detects differential chromatin accessibility. Here, SeATAC uses a conditional variational autoencoder model to learn the latent representation of ATAC-seq V-plots and outperforms MACS2 and NucleoATAC on six separate tasks. Applying SeATAC to several pioneer factor-induced differentiation or reprogramming ATAC-seq datasets suggests that induction of these factors not only relaxes the closed chromatin but also decreases chromatin accessibility of 20% to 30% of their target sites. SeATAC is a novel tool to accurately reveal genomic regions with differential chromatin accessibility from ATAC-seq data." @default.
• W4377293234 created "2023-05-23" @default.
• W4377293234 creator A5002087436 @default.
• W4377293234 creator A5036817888 @default.
• W4377293234 creator A5066838536 @default.
• W4377293234 date "2023-05-22" @default.
• W4377293234 modified "2023-09-27" @default.
• W4377293234 title "SeATAC: a tool for exploring the chromatin landscape and the role of pioneer factors" @default.
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• W4377293234 doi "https://doi.org/10.1186/s13059-023-02954-5" @default.
• W4377293234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37218013" @default.
• W4377293234 hasPublicationYear "2023" @default.

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