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- W4377564064 startingPage "41" @default.
- W4377564064 abstract "Astrocytes are the most abundant glial cell type in the central nervous system and are essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are heterogeneous, with their diversity rooted in developmental programs modulated by the local brain environment. Astrocytes play integral roles in regulating and coordinating neural activity extending far beyond their metabolic support of neurons and other brain cell phenotypes. Both gray and white matter astrocytes occupy critical functional niches capable of modulating brain physiology on time scales slower than synaptic activity but faster than those adaptive responses requiring a structural change or adaptive myelination. Given their many associations and functional roles, it is not surprising that astrocytic dysfunction has been causally implicated in a broad set of neurodegenerative and neuropsychiatric disorders. In this review, we focus on recent discoveries concerning the contributions of astrocytes to the function of neural networks, with a dual focus on the contribution of astrocytes to synaptic development and maturation, and on their role in supporting myelin integrity, and hence conduction and its regulation. We then address the emerging roles of astrocytic dysfunction in disease pathogenesis and on potential strategies for targeting these cells for therapeutic purposes." @default.
- W4377564064 created "2023-05-24" @default.
- W4377564064 creator A5032584291 @default.
- W4377564064 creator A5080717862 @default.
- W4377564064 creator A5081959312 @default.
- W4377564064 date "2023-05-23" @default.
- W4377564064 modified "2023-10-14" @default.
- W4377564064 title "Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes" @default.
- W4377564064 cites W1513082520 @default.
- W4377564064 cites W1542136448 @default.
- W4377564064 cites W1564335246 @default.
- W4377564064 cites W1639356345 @default.
- W4377564064 cites W1977543000 @default.
- W4377564064 cites W1977838764 @default.
- W4377564064 cites W1979286083 @default.
- W4377564064 cites W1979365023 @default.
- W4377564064 cites W1980775054 @default.
- W4377564064 cites W1988452935 @default.
- W4377564064 cites W1992085076 @default.
- W4377564064 cites W1993629125 @default.
- W4377564064 cites W1995219764 @default.
- W4377564064 cites W1996603253 @default.
- W4377564064 cites W2005760116 @default.
- W4377564064 cites W2008165339 @default.
- W4377564064 cites W2012422256 @default.
- W4377564064 cites W2012459072 @default.
- W4377564064 cites W2012935976 @default.
- W4377564064 cites W2013994080 @default.
- W4377564064 cites W2022809683 @default.
- W4377564064 cites W2023962370 @default.
- W4377564064 cites W2026147918 @default.
- W4377564064 cites W2026211597 @default.
- W4377564064 cites W2031155687 @default.
- W4377564064 cites W2031611126 @default.
- W4377564064 cites W2031784369 @default.
- W4377564064 cites W2032229924 @default.
- W4377564064 cites W2036638493 @default.
- W4377564064 cites W2042528531 @default.
- W4377564064 cites W2042914897 @default.
- W4377564064 cites W2047687007 @default.
- W4377564064 cites W2050382124 @default.
- W4377564064 cites W2051698120 @default.
- W4377564064 cites W2059681878 @default.
- W4377564064 cites W2060982295 @default.
- W4377564064 cites W2065556020 @default.
- W4377564064 cites W2069264323 @default.
- W4377564064 cites W2071467012 @default.
- W4377564064 cites W2072885702 @default.
- W4377564064 cites W2074264738 @default.
- W4377564064 cites W2076310752 @default.
- W4377564064 cites W2077596732 @default.
- W4377564064 cites W2077702475 @default.
- W4377564064 cites W2079574859 @default.
- W4377564064 cites W2081116856 @default.
- W4377564064 cites W2089187494 @default.
- W4377564064 cites W2095780210 @default.
- W4377564064 cites W2098622411 @default.
- W4377564064 cites W2099295630 @default.
- W4377564064 cites W2099435261 @default.
- W4377564064 cites W2104736206 @default.
- W4377564064 cites W2108005154 @default.
- W4377564064 cites W2108583379 @default.
- W4377564064 cites W2108994842 @default.
- W4377564064 cites W2114008977 @default.
- W4377564064 cites W2115565454 @default.
- W4377564064 cites W2116308842 @default.
- W4377564064 cites W2117787632 @default.
- W4377564064 cites W2119987649 @default.
- W4377564064 cites W2120144854 @default.
- W4377564064 cites W2126123436 @default.
- W4377564064 cites W2128071454 @default.
- W4377564064 cites W2129031013 @default.
- W4377564064 cites W2129082075 @default.
- W4377564064 cites W2129567809 @default.
- W4377564064 cites W2132325919 @default.
- W4377564064 cites W2144117535 @default.
- W4377564064 cites W2144469764 @default.
- W4377564064 cites W2145015359 @default.
- W4377564064 cites W2147270524 @default.
- W4377564064 cites W2149615917 @default.
- W4377564064 cites W2149623878 @default.
- W4377564064 cites W2151183171 @default.
- W4377564064 cites W2152089134 @default.
- W4377564064 cites W2158093773 @default.
- W4377564064 cites W2161681716 @default.
- W4377564064 cites W2166338743 @default.
- W4377564064 cites W2166643977 @default.
- W4377564064 cites W2167604792 @default.
- W4377564064 cites W2179495678 @default.
- W4377564064 cites W2236139809 @default.
- W4377564064 cites W2272687938 @default.
- W4377564064 cites W2277434785 @default.
- W4377564064 cites W2298673178 @default.
- W4377564064 cites W2326520701 @default.
- W4377564064 cites W2338490890 @default.
- W4377564064 cites W2339180010 @default.
- W4377564064 cites W2343186916 @default.
- W4377564064 cites W2404695164 @default.