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- W4377564287 endingPage "2454" @default.
- W4377564287 startingPage "2439" @default.
- W4377564287 abstract "DNA methylation is the most stable epigenetic modification. In mammals, it usually occurs at the cytosine of CpG dinucleotides. DNA methylation is essential for many physiological and pathological processes. Aberrant DNA methylation has been observed in human diseases, particularly cancer. Notably, conventional DNA methylation profiling technologies require a large amount of DNA, often from a heterogeneous cell population, and provide an average methylation level of many cells. It is often not realistic to collect sufficient numbers of cells, such as rare cells and circulating tumor cells in peripheral blood, for bulk sequencing assays. It is therefore essential to develop sequencing technologies that can accurately profile DNA methylation using small numbers of cells or even single cells. Excitingly, many single-cell DNA methylation sequencing and single-cell omics sequencing technologies have been developed, and applications of these methods have greatly expanded our understanding of the molecular mechanism of DNA methylation. Here, we summaries single-cell DNA methylation and multi-omics sequencing methods, delineate their applications in biomedical sciences, discuss technical challenges, and present our perspective on future research directions." @default.
- W4377564287 created "2023-05-24" @default.
- W4377564287 creator A5031545775 @default.
- W4377564287 creator A5059343454 @default.
- W4377564287 creator A5059400646 @default.
- W4377564287 creator A5085025467 @default.
- W4377564287 date "2023-01-01" @default.
- W4377564287 modified "2023-10-04" @default.
- W4377564287 title "Technologies and applications of single-cell DNA methylation sequencing" @default.
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