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- W4377564310 abstract "Measuring venous plasma paracetamol concentrations is time- and resource-consuming. We aimed to validate a novel electrochemical point-of-care (POC) assay for rapid paracetamol concentration determinations.Twelve healthy volunteers received 1 g oral paracetamol, and its concentrations were analysed 10 times over 12 h for capillary whole blood (POC), venous plasma (high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS)), and dried capillary blood (HPLC-MS/MS).At concentrations >30 μM, POC showed upward biases of 20% (95% limits of agreement [LOA] -22 to 62) and 7% (95% LOA -23 to 38) compared with venous plasma and capillary blood HPLC-MS/MS, respectively. There were no significant differences between mean concentrations for the paracetamol elimination phase.Upward biases in POC compared with venous plasma HPLC-MS/MS were likely due to higher paracetamol concentrations in capillary blood than in venous plasma and to faulty individual sensors. The novel POC method is a promising tool for paracetamol concentration analysis." @default.
- W4377564310 created "2023-05-24" @default.
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- W4377564310 date "2023-06-07" @default.
- W4377564310 modified "2023-10-16" @default.
- W4377564310 title "Introduction of an electrochemical point‐of‐care assay for quantitative determination of paracetamol in finger‐prick capillary whole blood samples" @default.
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- W4377564310 doi "https://doi.org/10.1111/bcp.15794" @default.
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