FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377564319> ?p ?o ?g. }

• W4377564319 abstract "Introduction: Cognitive impairment is a common complication and comorbidity of diabetes. However, the underlying mechanisms of diabetes-associated cognitive dysfunction are currently unclear. M1 microglia secretes pro-inflammatory factors and can be marked by CD16, iNOS, Iba1 and TNF-ɑ. The decline of M2 microglia in the diabetic rats indicates that high glucose promotes the differentiation of microglia into the M1 type to trigger neuroinflammatory responses. Moreover, there is a lack of strong evidence for treatments of diabetes-associated cognitive impairment in addition to controlling blood glucose. Methods: Diabetic rats were established by intraperitoneal injection of one dose of streptozotocin (60 mg/kg). Polarization transitions of microglia were induced by high glucose treatment in BV2 cells. Levetiracetam was orally administered to rats 72 h after streptozotocin injection for 12 weeks. Results: In STZ-induced diabetic rats, the results demonstrated that levetiracetam improved rat cognitive function (Morris water maze test) and hippocampus morphology (Hematoxylin-eosin staining), and the effect was more evident in the high-dose levetiracetam group. Microglia activation in the hippocampus was inhibited by levetiracetam treatment for 12 weeks. Serum levels of TNF-α, IL-1β, and IL-6 were reduced in the LEV-L and LEV-H groups, and IL-1β level was obviously reduced in the LEV-H group. In vitro, we found that levetiracetam 50 µM attenuated high-glucose induced microglial polarization by increasing IL-10 level and decreasing IL-1β and TNF-α levels. Moreover, levetiracetam 50 µM increased and decreased the proportion of CD206+/Iba1+ and iNOS+/Iba1+cells, respectively. Western blot analysis illustrated that LEV 50 µM downregulated the expression of MyD88 and TRAF6, and phosphorylation of TAK1, JNK, p38, and NF-κB p65. The effect of levetiracetam on the anti-polarization and expression of p-JNK and p-NF-κB p65 were partly reversed by anisomycin (p38 and JNK activators). Discussion: Together, our data suggest that levetiracetam attenuates streptozotocin-induced cognitive impairment by suppressing microglia activation. The in vitro findings also indicate that the levetiracetam inhibited the polarization of microglia via the JNK/MAPK/NF-κB signaling pathway." @default.
• W4377564319 created "2023-05-24" @default.
• W4377564319 creator A5048447336 @default.
• W4377564319 creator A5049352152 @default.
• W4377564319 creator A5060819626 @default.
• W4377564319 creator A5064419476 @default.
• W4377564319 creator A5065461635 @default.
• W4377564319 creator A5073431532 @default.
• W4377564319 date "2023-05-04" @default.
• W4377564319 modified "2023-09-26" @default.
• W4377564319 title "Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation" @default.
• W4377564319 cites W1517263647 @default.
• W4377564319 cites W1529718777 @default.
• W4377564319 cites W1711248712 @default.
• W4377564319 cites W2003026895 @default.
• W4377564319 cites W2019724009 @default.
• W4377564319 cites W2019825857 @default.
• W4377564319 cites W2026802237 @default.
• W4377564319 cites W2028911700 @default.
• W4377564319 cites W2039290396 @default.
• W4377564319 cites W2106137569 @default.
• W4377564319 cites W2113394933 @default.
• W4377564319 cites W2131027591 @default.
• W4377564319 cites W2134243884 @default.
• W4377564319 cites W2149450071 @default.
• W4377564319 cites W2150472993 @default.
• W4377564319 cites W2168312889 @default.
• W4377564319 cites W2194542772 @default.
• W4377564319 cites W2233400572 @default.
• W4377564319 cites W2318020762 @default.
• W4377564319 cites W2587680743 @default.
• W4377564319 cites W2614116711 @default.
• W4377564319 cites W2766011156 @default.
• W4377564319 cites W2774135365 @default.
• W4377564319 cites W2884234047 @default.
• W4377564319 cites W2904871119 @default.
• W4377564319 cites W2912343713 @default.
• W4377564319 cites W2939798759 @default.
• W4377564319 cites W2952841998 @default.
• W4377564319 cites W2954206828 @default.
• W4377564319 cites W2979744254 @default.
• W4377564319 cites W2983091449 @default.
• W4377564319 cites W2995880383 @default.
• W4377564319 cites W3014808271 @default.
• W4377564319 cites W3015975167 @default.
• W4377564319 cites W3028705302 @default.
• W4377564319 cites W3029606718 @default.
• W4377564319 cites W3033216362 @default.
• W4377564319 cites W3092360972 @default.
• W4377564319 cites W3104163758 @default.
• W4377564319 cites W3104856763 @default.
• W4377564319 cites W3107804789 @default.
• W4377564319 cites W3160743591 @default.
• W4377564319 cites W3202631805 @default.
• W4377564319 cites W3204790500 @default.
• W4377564319 cites W3206040570 @default.
• W4377564319 cites W4210365003 @default.
• W4377564319 cites W4220660729 @default.
• W4377564319 cites W4250838323 @default.
• W4377564319 cites W4251012829 @default.
• W4377564319 cites W4283379941 @default.
• W4377564319 cites W4285005540 @default.
• W4377564319 cites W4285093312 @default.
• W4377564319 cites W4293089776 @default.
• W4377564319 cites W4300981509 @default.
• W4377564319 doi "https://doi.org/10.3389/fphar.2023.1145819" @default.
• W4377564319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37214458" @default.
• W4377564319 hasPublicationYear "2023" @default.
• W4377564319 type Work @default.
• W4377564319 citedByCount "1" @default.
• W4377564319 countsByYear W43775643192023 @default.
• W4377564319 crossrefType "journal-article" @default.
• W4377564319 hasAuthorship W4377564319A5048447336 @default.
• W4377564319 hasAuthorship W4377564319A5049352152 @default.
• W4377564319 hasAuthorship W4377564319A5060819626 @default.
• W4377564319 hasAuthorship W4377564319A5064419476 @default.
• W4377564319 hasAuthorship W4377564319A5065461635 @default.
• W4377564319 hasAuthorship W4377564319A5073431532 @default.
• W4377564319 hasBestOaLocation W43775643191 @default.
• W4377564319 hasConcept C118552586 @default.
• W4377564319 hasConcept C126322002 @default.
• W4377564319 hasConcept C134018914 @default.
• W4377564319 hasConcept C2776914184 @default.
• W4377564319 hasConcept C2777332695 @default.
• W4377564319 hasConcept C2778186239 @default.
• W4377564319 hasConcept C2779280383 @default.
• W4377564319 hasConcept C2779830541 @default.
• W4377564319 hasConcept C2780159080 @default.
• W4377564319 hasConcept C2781161787 @default.
• W4377564319 hasConcept C44752575 @default.
• W4377564319 hasConcept C555293320 @default.
• W4377564319 hasConcept C71924100 @default.
• W4377564319 hasConcept C87753298 @default.
• W4377564319 hasConcept C98274493 @default.
• W4377564319 hasConceptScore W4377564319C118552586 @default.
• W4377564319 hasConceptScore W4377564319C126322002 @default.
• W4377564319 hasConceptScore W4377564319C134018914 @default.
• W4377564319 hasConceptScore W4377564319C2776914184 @default.
• W4377564319 hasConceptScore W4377564319C2777332695 @default.
• W4377564319 hasConceptScore W4377564319C2778186239 @default.

• next