Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377564327> ?p ?o ?g. }
- W4377564327 abstract "Mesenchymal stem cells (MSCs) are the hotspots of cellular therapy due to their low immunogenicity, potent immunoregulation, and unique renoprotection. The present study aimed to investigate the effects of periosteum-derived MSCs (PMSCs) in ischemia-reperfusion (IR)-mediated renal fibrosis.Using cell proliferation assay, flow cytometry, immunofluorescence, and histologic analysis, the differences in cell characteristics, immunoregulation, and renoprotection of PMSCs were compared to the bone marrow-derived MSCs (BMSCs), the most frequently studied stem cells in cellular therapy. In addition, the mechanism of PMSC renoprotection was investigated by 5' end of the RNA transcript sequencing (SMART-seq) and mTOR knockout mice.The proliferation and differentiation capabilities of PMSCs were stronger than those of BMSCs. Compared with BMSCs, the PMSCs exerted a better effect on alleviating renal fibrosis. Meanwhile, the PMSCs more effectively promote Treg differentiation. Treg exhaustion experiment indicated that Tregs exerted an important effect on inhibiting renal inflammation and acted as a critical mediator in PMSC renoprotection. Additionally, SMART-seq results implied that the PMSCs promoted Treg differentiation, possibly via the mTOR pathway. In vivo and in vitro experiments showed that PMSC inhibited mTOR phosphorylation of Treg. After mTOR knockout, the PMSCs failed to promote Treg differentiation.Compared with BMSCs, the PMSCs exerted stronger immunoregulation and renoprotection that was mainly attributed to PMSC promotion for Treg differentiation by inhibiting the mTOR pathway." @default.
- W4377564327 created "2023-05-24" @default.
- W4377564327 creator A5024048854 @default.
- W4377564327 creator A5030695381 @default.
- W4377564327 creator A5033447836 @default.
- W4377564327 creator A5037441265 @default.
- W4377564327 creator A5048254486 @default.
- W4377564327 creator A5049225588 @default.
- W4377564327 creator A5060881656 @default.
- W4377564327 creator A5064050907 @default.
- W4377564327 creator A5065773926 @default.
- W4377564327 creator A5071170791 @default.
- W4377564327 creator A5075821768 @default.
- W4377564327 creator A5080604226 @default.
- W4377564327 creator A5082969451 @default.
- W4377564327 creator A5088804993 @default.
- W4377564327 creator A5090596485 @default.
- W4377564327 creator A5091798913 @default.
- W4377564327 date "2023-05-23" @default.
- W4377564327 modified "2023-10-18" @default.
- W4377564327 title "Periosteum-derived mesenchymal stem cell alleviates renal fibrosis through mTOR-mediated Treg differentiation" @default.
- W4377564327 cites W1967524272 @default.
- W4377564327 cites W1990212276 @default.
- W4377564327 cites W1991151250 @default.
- W4377564327 cites W2010727369 @default.
- W4377564327 cites W2016189233 @default.
- W4377564327 cites W2017654538 @default.
- W4377564327 cites W2021690806 @default.
- W4377564327 cites W2061124209 @default.
- W4377564327 cites W2066538153 @default.
- W4377564327 cites W2089878334 @default.
- W4377564327 cites W2092810335 @default.
- W4377564327 cites W2096291727 @default.
- W4377564327 cites W2112650944 @default.
- W4377564327 cites W2197331811 @default.
- W4377564327 cites W2371948111 @default.
- W4377564327 cites W2766971919 @default.
- W4377564327 cites W2767660100 @default.
- W4377564327 cites W2790965559 @default.
- W4377564327 cites W2888922388 @default.
- W4377564327 cites W2910715320 @default.
- W4377564327 cites W2912968829 @default.
- W4377564327 cites W2943914150 @default.
- W4377564327 cites W2950854031 @default.
- W4377564327 cites W2965698862 @default.
- W4377564327 cites W2999978118 @default.
- W4377564327 cites W3043861550 @default.
- W4377564327 cites W3044578606 @default.
- W4377564327 cites W3154535656 @default.
- W4377564327 cites W3170891599 @default.
- W4377564327 cites W4206685157 @default.
- W4377564327 cites W4212970509 @default.
- W4377564327 cites W4213346277 @default.
- W4377564327 doi "https://doi.org/10.1080/0886022x.2023.2212079" @default.
- W4377564327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37218597" @default.
- W4377564327 hasPublicationYear "2023" @default.
- W4377564327 type Work @default.
- W4377564327 citedByCount "1" @default.
- W4377564327 countsByYear W43775643272023 @default.
- W4377564327 crossrefType "journal-article" @default.
- W4377564327 hasAuthorship W4377564327A5024048854 @default.
- W4377564327 hasAuthorship W4377564327A5030695381 @default.
- W4377564327 hasAuthorship W4377564327A5033447836 @default.
- W4377564327 hasAuthorship W4377564327A5037441265 @default.
- W4377564327 hasAuthorship W4377564327A5048254486 @default.
- W4377564327 hasAuthorship W4377564327A5049225588 @default.
- W4377564327 hasAuthorship W4377564327A5060881656 @default.
- W4377564327 hasAuthorship W4377564327A5064050907 @default.
- W4377564327 hasAuthorship W4377564327A5065773926 @default.
- W4377564327 hasAuthorship W4377564327A5071170791 @default.
- W4377564327 hasAuthorship W4377564327A5075821768 @default.
- W4377564327 hasAuthorship W4377564327A5080604226 @default.
- W4377564327 hasAuthorship W4377564327A5082969451 @default.
- W4377564327 hasAuthorship W4377564327A5088804993 @default.
- W4377564327 hasAuthorship W4377564327A5090596485 @default.
- W4377564327 hasAuthorship W4377564327A5091798913 @default.
- W4377564327 hasBestOaLocation W43775643271 @default.
- W4377564327 hasConcept C104317684 @default.
- W4377564327 hasConcept C142724271 @default.
- W4377564327 hasConcept C148738053 @default.
- W4377564327 hasConcept C198826908 @default.
- W4377564327 hasConcept C203014093 @default.
- W4377564327 hasConcept C28328180 @default.
- W4377564327 hasConcept C502942594 @default.
- W4377564327 hasConcept C55493867 @default.
- W4377564327 hasConcept C62478195 @default.
- W4377564327 hasConcept C71924100 @default.
- W4377564327 hasConcept C86554907 @default.
- W4377564327 hasConcept C86803240 @default.
- W4377564327 hasConcept C95444343 @default.
- W4377564327 hasConceptScore W4377564327C104317684 @default.
- W4377564327 hasConceptScore W4377564327C142724271 @default.
- W4377564327 hasConceptScore W4377564327C148738053 @default.
- W4377564327 hasConceptScore W4377564327C198826908 @default.
- W4377564327 hasConceptScore W4377564327C203014093 @default.
- W4377564327 hasConceptScore W4377564327C28328180 @default.
- W4377564327 hasConceptScore W4377564327C502942594 @default.
- W4377564327 hasConceptScore W4377564327C55493867 @default.
- W4377564327 hasConceptScore W4377564327C62478195 @default.
- W4377564327 hasConceptScore W4377564327C71924100 @default.