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- W4377564341 endingPage "1073" @default.
- W4377564341 startingPage "1061" @default.
- W4377564341 abstract "Abstract The marsupial Monito del monte ( Dromiciops gliroides ) utilizes both daily and seasonal bouts of torpor to preserve energy and prolong survival during periods of cold and unpredictable food availability. Torpor involves changes in cellular metabolism, including specific changes to gene expression that is coordinated in part, by the posttranscriptional gene silencing activity of microRNAs (miRNA). Previously, differential miRNA expression has been identified in D . gliroides liver and skeletal muscle; however, miRNAs in the heart of Monito del monte remained unstudied. In this study, the expression of 82 miRNAs was assessed in the hearts of active and torpid D . gliroides , finding that 14 were significantly differentially expressed during torpor. These 14 miRNAs were then used in bioinformatic analyses to identify Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were predicted to be most affected by these differentially expressed miRNAs. Overexpressed miRNAs were predicted to primarily regulate glycosaminoglycan biosynthesis, along with various signaling pathways such as Phosphoinositide‐3‐kinase/protein kinase B and transforming growth factor‐β. Similarly, signaling pathways including phosphatidylinositol and Hippo were predicted to be regulated by the underexpression of miRNAs during torpor. Together, these results suggest potential molecular adaptations that protect against irreversible tissue damage and enable continued cardiac and vascular function despite hypothermia and limited organ perfusion during torpor." @default.
- W4377564341 created "2023-05-24" @default.
- W4377564341 creator A5019635992 @default.
- W4377564341 creator A5034734135 @default.
- W4377564341 creator A5043990517 @default.
- W4377564341 creator A5070005270 @default.
- W4377564341 creator A5084193426 @default.
- W4377564341 creator A5086778291 @default.
- W4377564341 date "2023-05-23" @default.
- W4377564341 modified "2023-10-14" @default.
- W4377564341 title "Torpor‐responsive <scp>microRNAs</scp> in the heart of the Monito del monte, <i>Dromiciops gliroides</i>" @default.
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