FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377564420> ?p ?o ?g. }

• W4377564420 abstract "Achilles tendon rupture is a common debilitating medical condition. The healing process is slow and can be affected by heterotopic ossification (HO), which occurs when pathologic bone-like tissue is deposited instead of the soft collagenous tendon tissue. Little is known about the temporal and spatial progression of HO during Achilles tendon healing. In this study we characterize HO deposition, microstructure, and location at different stages of healing in a rat model. We use phase contrast-enhanced synchrotron microtomography, a state-of-the-art technique that allows 3D imaging at high-resolution of soft biological tissues without invasive or time-consuming sample preparation. The results increase our understanding of HO deposition, from the early inflammatory phase of tendon healing, by showing that the deposition is initiated as early as one week after injury in the distal stump and mostly growing on preinjury HO deposits. Later, more deposits form first in the stumps and then all over the tendon callus, merging into large, calcified structures, which occupy up to 10% of the tendon volume. The HOs were characterized by a looser connective trabecular-like structure and a proteoglycan-rich matrix containing chondrocyte-like cells with lacunae. The study shows the potential of 3D imaging at high-resolution by phase-contrast tomography to better understand ossification in healing tendons." @default.
• W4377564420 created "2023-05-24" @default.
• W4377564420 creator A5029110250 @default.
• W4377564420 creator A5038538042 @default.
• W4377564420 creator A5054303610 @default.
• W4377564420 creator A5074735538 @default.
• W4377564420 creator A5086128005 @default.
• W4377564420 creator A5087615742 @default.
• W4377564420 creator A5088348865 @default.
• W4377564420 creator A5091374536 @default.
• W4377564420 date "2023-05-23" @default.
• W4377564420 modified "2023-10-16" @default.
• W4377564420 title "Spatiotemporal and microstructural characterization of heterotopic ossification in healing rat Achilles tendons" @default.
• W4377564420 cites W1853171333 @default.
• W4377564420 cites W1964204876 @default.
• W4377564420 cites W1970596483 @default.
• W4377564420 cites W1974293480 @default.
• W4377564420 cites W1979046280 @default.
• W4377564420 cites W1985719774 @default.
• W4377564420 cites W1991063851 @default.
• W4377564420 cites W2019390237 @default.
• W4377564420 cites W2020501368 @default.
• W4377564420 cites W2026736019 @default.
• W4377564420 cites W2030381058 @default.
• W4377564420 cites W2045545457 @default.
• W4377564420 cites W2050417925 @default.
• W4377564420 cites W2052208249 @default.
• W4377564420 cites W2070696494 @default.
• W4377564420 cites W2083803155 @default.
• W4377564420 cites W2086614235 @default.
• W4377564420 cites W2107848323 @default.
• W4377564420 cites W2137490913 @default.
• W4377564420 cites W2143542059 @default.
• W4377564420 cites W2149181513 @default.
• W4377564420 cites W2149429224 @default.
• W4377564420 cites W2152367550 @default.
• W4377564420 cites W2162700482 @default.
• W4377564420 cites W2282141885 @default.
• W4377564420 cites W2299794012 @default.
• W4377564420 cites W2338136789 @default.
• W4377564420 cites W2580035316 @default.
• W4377564420 cites W2603619446 @default.
• W4377564420 cites W2604740419 @default.
• W4377564420 cites W2751780311 @default.
• W4377564420 cites W2752159338 @default.
• W4377564420 cites W2883767776 @default.
• W4377564420 cites W2885183820 @default.
• W4377564420 cites W2897727823 @default.
• W4377564420 cites W2943789709 @default.
• W4377564420 cites W2946153877 @default.
• W4377564420 cites W2966422204 @default.
• W4377564420 cites W2993980057 @default.
• W4377564420 cites W2999750669 @default.
• W4377564420 cites W3021856761 @default.
• W4377564420 cites W3033560945 @default.
• W4377564420 cites W3043613295 @default.
• W4377564420 cites W3049248537 @default.
• W4377564420 cites W3080215359 @default.
• W4377564420 cites W3081151586 @default.
• W4377564420 cites W3110951804 @default.
• W4377564420 cites W3113216470 @default.
• W4377564420 cites W3193291642 @default.
• W4377564420 cites W4288735285 @default.
• W4377564420 cites W4293258489 @default.
• W4377564420 cites W4321793630 @default.
• W4377564420 doi "https://doi.org/10.1096/fj.202201018rrr" @default.
• W4377564420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37219456" @default.
• W4377564420 hasPublicationYear "2023" @default.
• W4377564420 type Work @default.
• W4377564420 citedByCount "0" @default.
• W4377564420 crossrefType "journal-article" @default.
• W4377564420 hasAuthorship W4377564420A5029110250 @default.
• W4377564420 hasAuthorship W4377564420A5038538042 @default.
• W4377564420 hasAuthorship W4377564420A5054303610 @default.
• W4377564420 hasAuthorship W4377564420A5074735538 @default.
• W4377564420 hasAuthorship W4377564420A5086128005 @default.
• W4377564420 hasAuthorship W4377564420A5087615742 @default.
• W4377564420 hasAuthorship W4377564420A5088348865 @default.
• W4377564420 hasAuthorship W4377564420A5091374536 @default.
• W4377564420 hasBestOaLocation W43775644201 @default.
• W4377564420 hasConcept C105702510 @default.
• W4377564420 hasConcept C126838900 @default.
• W4377564420 hasConcept C127313418 @default.
• W4377564420 hasConcept C136948725 @default.
• W4377564420 hasConcept C142724271 @default.
• W4377564420 hasConcept C174286582 @default.
• W4377564420 hasConcept C2777825092 @default.
• W4377564420 hasConcept C2778842504 @default.
• W4377564420 hasConcept C2780105995 @default.
• W4377564420 hasConcept C2780650075 @default.
• W4377564420 hasConcept C2780984734 @default.
• W4377564420 hasConcept C3020199158 @default.
• W4377564420 hasConcept C518705261 @default.
• W4377564420 hasConcept C62649853 @default.
• W4377564420 hasConcept C71924100 @default.
• W4377564420 hasConceptScore W4377564420C105702510 @default.
• W4377564420 hasConceptScore W4377564420C126838900 @default.
• W4377564420 hasConceptScore W4377564420C127313418 @default.
• W4377564420 hasConceptScore W4377564420C136948725 @default.
• W4377564420 hasConceptScore W4377564420C142724271 @default.

• next