Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377564504> ?p ?o ?g. }
- W4377564504 abstract "LldR is a lactate-responsive transcription factor (TF) that transcriptionally regulates the lldPRD operon consisting of lactate permease and lactate dehydrogenase. The lldPRD operon facilitates the utilisation of lactic acid in bacteria. However, the role of LldR in whole genomic transcriptional regulation, and the mechanism involved in adaptation to lactate remains unclear. We used genomic SELEX (gSELEX) to comprehensively analyse the genomic regulatory network of LldR to understand the overall regulatory mechanism of lactic acid adaptation of the model intestinal bacterium Escherichia coli . In addition to the involvement of the lldPRD operon in utilising lactate as a carbon source, genes related to glutamate-dependent acid resistance and altering the composition of membrane lipids were identified as novel targets of LldR. A series of in vitro and in vivo regulatory analyses led to the identification of LldR as an activator of these genes. Furthermore, the results of lactic acid tolerance tests and co-culture experiments with lactic acid bacteria suggested that LldR plays a significant role in adapting to the acid stress induced by lactic acid. Therefore, we propose that LldR is an l -/ d -lactate sensing TF for utilising lactate as a carbon source and for resistance to lactate-induced acid stress in intestinal bacteria." @default.
- W4377564504 created "2023-05-24" @default.
- W4377564504 creator A5003104495 @default.
- W4377564504 creator A5018921635 @default.
- W4377564504 creator A5050099758 @default.
- W4377564504 creator A5053933218 @default.
- W4377564504 creator A5061595177 @default.
- W4377564504 creator A5066881648 @default.
- W4377564504 date "2023-05-23" @default.
- W4377564504 modified "2023-09-28" @default.
- W4377564504 title "Expanded roles of lactate-sensing LldR in transcription regulation of the Escherichia coli K-12 genome: lactate utilisation and acid resistance" @default.
- W4377564504 cites W1522037109 @default.
- W4377564504 cites W1556215826 @default.
- W4377564504 cites W1563686976 @default.
- W4377564504 cites W1599642480 @default.
- W4377564504 cites W1611980546 @default.
- W4377564504 cites W1741228629 @default.
- W4377564504 cites W1804505009 @default.
- W4377564504 cites W1817309254 @default.
- W4377564504 cites W1896856656 @default.
- W4377564504 cites W1991828007 @default.
- W4377564504 cites W2004254961 @default.
- W4377564504 cites W2006061929 @default.
- W4377564504 cites W2006592453 @default.
- W4377564504 cites W2007599192 @default.
- W4377564504 cites W2032867950 @default.
- W4377564504 cites W2036099827 @default.
- W4377564504 cites W2051449352 @default.
- W4377564504 cites W2074215101 @default.
- W4377564504 cites W2079893830 @default.
- W4377564504 cites W2080993758 @default.
- W4377564504 cites W2093286425 @default.
- W4377564504 cites W2093548226 @default.
- W4377564504 cites W2096226074 @default.
- W4377564504 cites W2111967267 @default.
- W4377564504 cites W2114411529 @default.
- W4377564504 cites W2116137883 @default.
- W4377564504 cites W2116182356 @default.
- W4377564504 cites W2121365413 @default.
- W4377564504 cites W2122395276 @default.
- W4377564504 cites W2128404962 @default.
- W4377564504 cites W2130212719 @default.
- W4377564504 cites W2131410730 @default.
- W4377564504 cites W2133012764 @default.
- W4377564504 cites W2133291667 @default.
- W4377564504 cites W2134539949 @default.
- W4377564504 cites W2138457121 @default.
- W4377564504 cites W2147161211 @default.
- W4377564504 cites W2148382830 @default.
- W4377564504 cites W2149889831 @default.
- W4377564504 cites W2152824658 @default.
- W4377564504 cites W2153695031 @default.
- W4377564504 cites W2157009395 @default.
- W4377564504 cites W2262666557 @default.
- W4377564504 cites W2567777922 @default.
- W4377564504 cites W2763602830 @default.
- W4377564504 cites W2790954929 @default.
- W4377564504 cites W2804113118 @default.
- W4377564504 cites W2807517165 @default.
- W4377564504 cites W2887566065 @default.
- W4377564504 cites W2997383690 @default.
- W4377564504 cites W3005937877 @default.
- W4377564504 cites W3088327548 @default.
- W4377564504 cites W3101090153 @default.
- W4377564504 cites W3174607828 @default.
- W4377564504 cites W3176439813 @default.
- W4377564504 cites W3211910140 @default.
- W4377564504 cites W61199343 @default.
- W4377564504 doi "https://doi.org/10.1099/mgen.0.001015" @default.
- W4377564504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37219924" @default.
- W4377564504 hasPublicationYear "2023" @default.
- W4377564504 type Work @default.
- W4377564504 citedByCount "0" @default.
- W4377564504 crossrefType "journal-article" @default.
- W4377564504 hasAuthorship W4377564504A5003104495 @default.
- W4377564504 hasAuthorship W4377564504A5018921635 @default.
- W4377564504 hasAuthorship W4377564504A5050099758 @default.
- W4377564504 hasAuthorship W4377564504A5053933218 @default.
- W4377564504 hasAuthorship W4377564504A5061595177 @default.
- W4377564504 hasAuthorship W4377564504A5066881648 @default.
- W4377564504 hasBestOaLocation W43775645041 @default.
- W4377564504 hasConcept C104317684 @default.
- W4377564504 hasConcept C181199279 @default.
- W4377564504 hasConcept C185592680 @default.
- W4377564504 hasConcept C203075996 @default.
- W4377564504 hasConcept C2775920511 @default.
- W4377564504 hasConcept C2777318727 @default.
- W4377564504 hasConcept C523546767 @default.
- W4377564504 hasConcept C54355233 @default.
- W4377564504 hasConcept C547475151 @default.
- W4377564504 hasConcept C55493867 @default.
- W4377564504 hasConcept C86803240 @default.
- W4377564504 hasConceptScore W4377564504C104317684 @default.
- W4377564504 hasConceptScore W4377564504C181199279 @default.
- W4377564504 hasConceptScore W4377564504C185592680 @default.
- W4377564504 hasConceptScore W4377564504C203075996 @default.
- W4377564504 hasConceptScore W4377564504C2775920511 @default.
- W4377564504 hasConceptScore W4377564504C2777318727 @default.
- W4377564504 hasConceptScore W4377564504C523546767 @default.
- W4377564504 hasConceptScore W4377564504C54355233 @default.