FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377564557> ?p ?o ?g. }

• W4377564557 abstract "Prototheca species are the only microalgae known to cause opportunistic infections in vertebrates and humans. Most cases of protothecosis in humans are caused by Prototheca wickerhamii, but knowledge of the pathogenicity and biology of Prototheca is limited. Globally, the diagnostic rate of Prototheca species infection is much lower than the actual rate of P. wickerhamii. The precise mechanisms underlying the pathogenesis of Prototheca infections remain unclear. In this study, we identified a strain of P. wickerhamii with atypical colony morphology. To reveal the morphological differences between P. wickerhamii S1 (mucous) and the molecular basis of its pathogenicity, the transcriptomics, proteomics, and metabolomics of two pathogenic P. wickerhamii strains and one environmental strain were analysed. Interestingly, mannan endo-1,4-β-mannosidase was significantly downregulated in P. wickerhamii S1, which contributes to a thinner cell wall in S1 compared to strains with typical colony morphology, and the toxicity of macrophages is reduced. Metabolite analysis revealed that the mucoid appearance of P. wickerhamii S1 may have been caused by an increase in linoleic acid, glycerol, and other metabolites. There is still a need to better understand the ecology, aetiology, and pathogenesis of P. wickerhamii, and in particular, its transmission between humans, animals, and the environment, from a One Health perspective." @default.
• W4377564557 created "2023-05-24" @default.
• W4377564557 creator A5003457826 @default.
• W4377564557 creator A5005381760 @default.
• W4377564557 creator A5026071162 @default.
• W4377564557 creator A5034804424 @default.
• W4377564557 creator A5065019668 @default.
• W4377564557 creator A5089092780 @default.
• W4377564557 date "2023-05-05" @default.
• W4377564557 modified "2023-09-27" @default.
• W4377564557 title "Integration of transcriptomics, proteomics, and metabolomics data for the detection of the human pathogenic Prototheca wickerhamii from a One Health perspective" @default.
• W4377564557 cites W1874868183 @default.
• W4377564557 cites W1977970412 @default.
• W4377564557 cites W1999574084 @default.
• W4377564557 cites W2066570544 @default.
• W4377564557 cites W2079061809 @default.
• W4377564557 cites W2114165700 @default.
• W4377564557 cites W2145876138 @default.
• W4377564557 cites W2170551349 @default.
• W4377564557 cites W2179438025 @default.
• W4377564557 cites W2514275796 @default.
• W4377564557 cites W2595120564 @default.
• W4377564557 cites W2734646761 @default.
• W4377564557 cites W2774072836 @default.
• W4377564557 cites W2799289308 @default.
• W4377564557 cites W2804879953 @default.
• W4377564557 cites W2900774776 @default.
• W4377564557 cites W2924579321 @default.
• W4377564557 cites W2968111670 @default.
• W4377564557 cites W3102284539 @default.
• W4377564557 cites W3136405188 @default.
• W4377564557 cites W3148317631 @default.
• W4377564557 cites W3148757910 @default.
• W4377564557 cites W3185567791 @default.
• W4377564557 cites W4210312421 @default.
• W4377564557 cites W4211205437 @default.
• W4377564557 cites W4213083552 @default.
• W4377564557 cites W4214689152 @default.
• W4377564557 cites W4225163405 @default.
• W4377564557 cites W4245353369 @default.
• W4377564557 cites W4283321860 @default.
• W4377564557 cites W4307428053 @default.
• W4377564557 doi "https://doi.org/10.3389/fcimb.2023.1152198" @default.
• W4377564557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37216181" @default.
• W4377564557 hasPublicationYear "2023" @default.
• W4377564557 type Work @default.
• W4377564557 citedByCount "0" @default.
• W4377564557 crossrefType "journal-article" @default.
• W4377564557 hasAuthorship W4377564557A5003457826 @default.
• W4377564557 hasAuthorship W4377564557A5005381760 @default.
• W4377564557 hasAuthorship W4377564557A5026071162 @default.
• W4377564557 hasAuthorship W4377564557A5034804424 @default.
• W4377564557 hasAuthorship W4377564557A5065019668 @default.
• W4377564557 hasAuthorship W4377564557A5089092780 @default.
• W4377564557 hasBestOaLocation W43775645571 @default.
• W4377564557 hasConcept C64502627 @default.
• W4377564557 hasConcept C86803240 @default.
• W4377564557 hasConcept C89423630 @default.
• W4377564557 hasConceptScore W4377564557C64502627 @default.
• W4377564557 hasConceptScore W4377564557C86803240 @default.
• W4377564557 hasConceptScore W4377564557C89423630 @default.
• W4377564557 hasLocation W43775645571 @default.
• W4377564557 hasLocation W43775645572 @default.
• W4377564557 hasOpenAccess W4377564557 @default.
• W4377564557 hasPrimaryLocation W43775645571 @default.
• W4377564557 hasRelatedWork W1449642797 @default.
• W4377564557 hasRelatedWork W1979359297 @default.
• W4377564557 hasRelatedWork W2007885361 @default.
• W4377564557 hasRelatedWork W2066936702 @default.
• W4377564557 hasRelatedWork W2312240337 @default.
• W4377564557 hasRelatedWork W2318695965 @default.
• W4377564557 hasRelatedWork W2483715905 @default.
• W4377564557 hasRelatedWork W2792194803 @default.
• W4377564557 hasRelatedWork W4297369327 @default.
• W4377564557 hasRelatedWork W2016100131 @default.
• W4377564557 hasVolume "13" @default.
• W4377564557 isParatext "false" @default.
• W4377564557 isRetracted "false" @default.
• W4377564557 workType "article" @default.