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- W4377564882 abstract "In this study, hyperpolarized 13C MRI (HP-13C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized 13C-pyruvate was administered to healthy aging individuals (N = 35, ages 21–77) and whole-brain spatial distributions of 13C-lactate and 13C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized 13C-lactate and normalized 13C-bicarbonate production with age: − 7 % ± 2 % per decade for 13C-lactate and − 9 % ± 4 % per decade for 13C-bicarbonate. Certain regions, such as the right medial precentral gyrus, showed greater rates of change while the left caudate nucleus had a flat 13C-lactate versus age and a slightly increasing 13C-bicarbonate versus age. The results show that both the production of lactate (visible as 13C-lactate signal) as well as the consumption of monocarboxylates to make acetyl-CoA (visible as 13C-bicarbonate signal) decrease with age and that the rate of change varies by brain region." @default.
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- W4377564882 date "2023-05-23" @default.
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- W4377564882 title "Age‐associated change in pyruvate metabolism investigated with hyperpolarized <scp><sup>13</sup>C‐MRI</scp> of the human brain" @default.
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- W4377564882 doi "https://doi.org/10.1002/hbm.26329" @default.
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