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- W4377564969 abstract "Transcription is the fundamental process of gene expression, which in eukaryotes occurs within the complex physicochemical environment of the nucleus. Decades of research have provided extreme detail in the molecular and functional mechanisms of transcription, but the spatial and genomic organization of transcription remains mysterious. Recent discoveries show that transcriptional components can undergo phase separation and create distinct compartments inside the nucleus, providing new models through which to view the transcription process in eukaryotes. In this review, we focus on transcriptional condensates and their phase separation-like behaviors. We suggest differentiation between physical descriptions of phase separation and the complex and dynamic biomolecular assemblies required for productive gene expression, and we discuss how transcriptional condensates are central to organizing the three-dimensional genome across spatial and temporal scales. Finally, we map approaches for therapeutic manipulation of transcriptional condensates and ask what technical advances are needed to understand transcriptional condensates more completely." @default.
- W4377564969 created "2023-05-24" @default.
- W4377564969 creator A5015876351 @default.
- W4377564969 creator A5021694651 @default.
- W4377564969 creator A5050887130 @default.
- W4377564969 date "2023-05-22" @default.
- W4377564969 modified "2023-09-26" @default.
- W4377564969 title "Transcriptional condensates and phase separation: condensing information across scales and mechanisms" @default.
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